7-keto DHEA side effects supplement, benefit, dosage, safety, danger 25 mg 50 mg, review of research studies, does it help with adrenal fatigue, menopause, lupus, or thyroid function
Is a 25 mg supplement safe or could it lead to untoward side effects? Do not buy 50 mg and 100 mg pills, by
Ray Sahelian, M.D.

March 24 2014

7-keto DHEA is a hormone similar to its cousin DHEA. Proponents claim that it cannot be metabolized to active androgenic or estrogenic hormones but enhances the immune system, memory, and has thermogenic effects of its cousin. I find this hard to understand. The same mechanisms and biochemical pathways that lead to the benefits they claim also are involved in causing side effects. If 7 keto dhea has testosterone like benefits, it is likely that a number of side effects will occur due to androgen excess.
   I am concerned that many people are misusing hormones such as pregnenolone, DHEA, and other androgen-like products. Some people are taking dosages that are too high or they are taking these hormones when they really do not need them. Some individuals may, in the future, regret having taken high amounts of these hormones for prolonged periods. Smaller amounts may be appropriate to use for specific purposes and for for a limited time as long as your health care provider approves. For this reason we have made a 7-keto DHEA supplement available but we suggest using only a portion of a capsule. The FDA has banned androstenedione for over the counter sale, but not 7keto.

Alternatives
If you are planning to use 7-keto DHEA for the purposes of weight control, consider a safer alternative called
Diet Rx which is a natural appetite suppressant without hormones. For sexual enhancement, consider Passion Rx which works extremely well. For mental enhancement, consider Mind Power Rx.

Human studies
As of February 2014 I have seen no new human studies with this hormone supplement since the last one published in the year 2000.

buy 7 Keto DHEA 25 mg per capsule or
DHEA 5 mg, 60 capsules

7-Keto-DHEA hormone 25 mg, for low libido in man, woman

 

 

 

Buy 7-Keto-DHEA supplement, DHEA supplement 5 mg, Passion Rx sex booster, Mind Power Rx brain booster

You recommend 5mg doses. the lowest I can find is 25 mg. Do you know of a reputable 5mg form that is available?
    I don't. You may consider taking a small portion of a capsule.

Summary and review
I am not aware of long term 7 keto DHEA human studies. Therefore, no recommendations regarding its use -- for weight loss, menopause, thyroid issues, depression, fertility, bodybuilding, blood pressure, osteoporosis, heart disease, breast cancer or prostate cancer -- can be made at this time except to say that I do not feel comfortable with the high dosages sold over the counter. I think a maximum of 5 mg is acceptable. Hormones are powerful substances that have significant short and long term effects. They can be very helpful if used appropriately but can cause serious harm if misused.

Passion Rx for better libido
Medical doctor formulated
for men and women. This all natural sexual booster is an herbal supplement that supports healthy stamina, sensation, and sexuality in men and women, along with satisfying erections and orgasms and climaxes. Passion Rx does not contain hormones or prescription drugs. The potent herbal extracts in this natural sex enhancing formula include ashwagandha, catuaba, cnidium, damiana herb, horny goat weed, maca, muira puama, passion flower, tribulus terrestris, and tongkat ali. A version of Passion Rx has yohimbe.

DHEA vs 7 Keto
Those who do not wish to use 7-keto-DHEA also have the option of regular DHEA
in 5 mg doses. Higher amounts -- for instance the most common dose sold is 25 mg -- should only be taken for brief periods, unless you have adrenal failure and need full replacement of adrenal hormones.

I am learning about androgens and new information including testosterone benefit and risks and was wondering how 7keto dhea compares to testosterone?
   It's difficult to say without seeing human study comparisons. It also depends on what condition is being treated.

Alternatives to hormones that are safer
Hormones provide benefits that may also be obtained in less dangerous ways. Here are some alternatives you may wish to explore:

For sexual enhancement, impotence or erectile dysfunction treatment, there are many libido enhancing herbs and supplements that are helpful. See the book Natural Sex Boosters for a detailed discussion or consider Passion Rx, a libido product that works in men and women.
For more stamina, see energy. MultiVit Rx is a comprehensive multivitamin formula that enhances natural energy.
Anti-aging benefit, see longevity. Learn about the latest practical suggestions on how to living longer.
For better blood sugar control see diabetes. You will find information on how to keep you blood sugar down with diet and natural supplements.
For depression treatment, I prefer 5 HTP, SAM-e, or St. John's wort natural antidepressants.

Bodybuilding and muscle growth
Do you think 7 keto dhea is useful for bodybuilding or increasing muscle mass and strength?
    I do not think this over the counter hormone supplement is safe and effective for bodybuilding or muscle growth. For bigger or more toned muscles, see creatine which helps build stronger and bigger muscles.

Estrogen effect
I have been taking 12.5mg daily for a few months. My estrogen blood results have gone above the recommend range. I have also been taking 300mg of chrysin during this period which is meant to lower my estrogen. Is it possible for 7 Keto DHEA to elevate my estrogen?
   Many claims are being made about it that are not based on science. Marketers are trying to make it seem like it has all the benefits of DHEA Hormone without the negative aspects. We think they are not being forthright with the public when they make claims like this. It is quite possible that 7-keto converts into estrogens.

Multiple sclerosis testimonial
I took DHEA for roughly 5 years for my multiple sclerosis. Studies have shown testosterone gel reduced relapses by 15%, and so I took it to increase my testosterone. It did reduce my MS symptoms and it was effective and safe to take even during a MS relapse. After 5 years I noticed I started having occasional pain in my perineum. I noticed that this coincided with my taking DHEA (or anything else that increased my testosterone.) Consequently, due to my concerns over potential prostate cancer, I stopped taking it. Thus, I turned to 7-keto. This does seem to provide some modest benefit in treating MS, but not as good as the regular DHEA. However, some benefit is better than no benefit at all. I will attest to the fact that the 7-keto DHEA does NOT cause the pain in my perenium. It does seem to cause weight loss for me, and it makes me a bit more focused but almost in a negative way, making me more analytical, and in consequence, a bit more irritable or almost depressed from over-analyzing or over-thinking.

Sports and athletic performance
Prohormones and sport. J Steroid Biochem Mol Biology. 2002.
Several precursors of testosterone and nandrolone introduced on the nutritional supplement market as performance enhancing drugs are banned in sports. The main metabolites of 7-keto-DHEA are 7-hydroxylated compounds. The commercial 1-androstenediol preparation was contaminated with several other anabolic steroids. Oxidation of 1-androstenediol to 1-androstenedione seems to be the major renal metabolic pathway. Additionally contaminated nutritional supplements containing banned substances not indicated on the label were administered. The results of the excretion studies indicate that after the intake of amounts substantially lower than the recommended dose athletes can fail a doping test for periods up to 120 hours.

Obesity
Prague Med Rep. 2012. 7-oxygenated derivatives of dehydroepiandrosterone and obesity. 7-hydroxy/oxo derivatives of dehydroepiandrosterone are potential regulators of the local cortisol activity due to their competition in the cortisolcortisone balance mediated by 11ß-hydroxysteroid dehydrogenase. 7-hydroxy-dehydroepiandrosterone is marketed as anti-obesity medication, though no clinical study aimed at the benefit of administering 7-oxygenated derivatives of dehydroepiandrosterone has appeared until now. We tried to show whether there exist differences in levels of circulating 7-hydroxy/oxo-dehydroepiandrosterone derivatives between lean and obese boys and girls. From a cohort of adolescents investigated within the frame of anti-obesity programme 10 obese boys and 10 obese girls were compared with age-matched lean boys and girls in their anthropometric data, and concentrations of both epimers of 7-hydroxy-dehydroepiandrosterone and 7-oxo-dehydroepiandrosterone were determined by the RIA method. The basal levels of 7α-hydroxy-dehydroepiandrosterone were significantly higher in obese boys than in lean boys but not in girls. The association was found for anthropometric parameters and 7α-hydroxy-dehydroepiandrosterone, however again only in boys and not in girls. Higher levels of 7α-hydroxy-dehydroepiandrosterone its positive association with anthropometric data in obese boys may serve as a sign that, at least in boys, 7-oxygenated 5-ene-steroids may take part in regulating the hormonal signal for fat formation or distribution.

Alcohol intake
Alcohol. 2011. Effects of 7-keto dehydroepiandrosterone on voluntary ethanol intake in male rats. Results show that 7-keto DHEA is comparable with, or possibly more effective than, DHEA at decreasing ethanol consumption in rats.

7- keto DHEA side effects, safety, risks, danger, hair loss
As with DHEA and pregnenolone, the most serious potential 7-keto dhea side effect is heart palpitations. Some people notice rapid heart beat or tachycardia. Acne is another potential adverse effect. We do not know if it has a strong influence on the thyroid gland or thyroid hormone levels. It is not known how it influences breast tissue, and whether it has an influence on breast cancer. We suspect long term use could cause hair loss.

You are right to be cautious regarding 3-Acetyl-Oxo-Dehydroeplandrosterone (7-ketodhea) marketed under the name PatentLean. My husband purchased 3 bottles of this product over the counter. I read the bottle and unfortunately believed the marketing hype of it being effective and that clinical results showed no negative side effects when used as directed. After approximately one week of following the manufacturer's instructions of taking 2 capsules a day of 100mg, I started to suffer heart palpitations and intense headaches. My husband who is usually very good natured became bad tempered and aggressive. After researching this product more fully, during which I discovered your website, I was appalled that the product claims are based on very little scientific evidence. We stopped taking the product immediately, and all of the symptoms have disappeared. Your website is of great public service. You are indeed correct when you advise people to do their own research regardless of the credentials of the person or persons making any claims.

Q. Last year I consulted a private nutritional doctor because I felt my lack of energy might be related to borderline thyroid function. I was prescribed thyroxine and also advised to take 7 keto DHEA 25 mg for adrenal support. Certainly my sex drive increased on this regime. Some months later I was advised to increase to 50mg daily but after a while began to develop facial hair, mostly in the moustache area. My private doctor advised me to stop taking the 7 keto but several months later I still have the increased facial hair and seem to have experienced some change of sexual identity in my reactions to seeing people of my own sex. I have never experienced this before. I'm happily married and have found this quite disturbing.
   A. Hormones are powerful substances and I have, for many years, asked the nutritional supplement industry to keep dosages over the counter limited to 5 or 10 mg and to warn people not to take these hormones daily without breaks. Being more sexual can tilt some individuals towards being attracted to both sexes and potentially the hormones may trigger certain areas in the brain that lead to be attracted to a member of the same sex.

At 46 I started reading a book about losing belly fat. One of the suggested supplements was 7-Keto dhea pills. At first I had no problem taking one pill at night. Then I realized from reading the bottle that I was supposed to take 1 three times daily so I started that about a month ago. Well, I have been having heart palpitations quite a bit. Sometimes my heart even hurts. Just the other day I was having anxiety and got overly upset about something.

A health food store owner recommended trying it for my tired and achy problems. I had tried many things and nothing helped. About 3-5 days later I noticed discomfort on my left side chest and my heart rate seemed high, pulsing through out my body. Researching this product online I came across your site. You had posted an email from someone who said 7-keto dhea had caused tachycardia. I'm sure this is what is happening to me. I am angry at the store owner but happy to have found this info online.

I was curious to know if any of your studies have connected 7-Keto DHEA with hair loss as a side effect. If so, does it appear to be more or less than that associated with DHEA alone?
   I suspect its use does lead to hair loss but I don't know whether it is more or less.

Q. As an adjunct instructor of nutrition and head of technical services for a private label supplement manufacturer I read a lot of company's information as well as numerous scientific journals. I was on your site, which I enjoy very much as you always have good science-based information, and noticed some negative comments made about the use of 7-keto. I'm confident based on the extensive research of Henry Lardy, PhD Professor Emeritus Biochemistry, University of Wisconsin, Madison of the safety of 7-keto. He and others have published numerous studies demonstrating its safety and efficacy. Some of the subjective information provided on your website cannot serve as a basis for a decision on whether or not to use it. One study that I can give you the reference for demonstrates the safety of 7-keto (I have an extensive list of other studies). I hope you get a chance to review Dr. Henry Lardy's work and others.
   I would like to respond to the statement from your website regarding 7-oxo DHEA (7-Keto). The combination of my graduate studies in nutrition, undergraduate studies in biology and chemistry and working in the nutraceutical industry has offered me the opportunity to meet and or speak with numerous researchers in various fields. I would like to share with you some of the published research on 7-oxo-DHEA, and hope to convince you of the safety and efficacy of this compound. There is nobody more qualified, in my mind, to speak on anything related to DHEA then Dr. Henry Lardy, Professor Emeritus, Institute for Enzyme Research, Department of Biochemistry, University of Wisconsin, Madison. As I’m sure you already know, the University of Wisconsin Madison has several researchers, both present and former, who have made major contributions to the fields of nutrition and biochemistry i.e. Michael Pariza, CLA research, Hector Deluca, vitamin D, James Ntambi, fatty acid biochemistry to name a few. With regard to your statement that “if 7 Keto DHEA has testosterone like benefits, it is likely that certain 7-keto DHEA side effects will be due to androgen excess”. Dr. Lardy and others have repeatedly shown that 7-Keto is a metabolite of and not a precursor to, either estrogen or testosterone. The positive metabolic effects reported for 7-oxo DHEA (7-Keto) are due to its ability to influence thermogenic enzymes i.e. malic enzyme to a greater extent than DHEA (without increasing testosterone and estrogen). 7-oxo DHEA (7-Keto) has been shown to be safe and effective in individuals (both healthy and overweight) at a dose of 200 mg/day.

Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers.
Clin Invest Med. 2000
Twenty-two healthy men received placebo or 3-acetyl-7-oxo-DHEA at 50 mg/d for 7 days followed by a 7-day washout; 100 mg/d for 7 days followed by a 7-day washout; and 200 mg/d for 28 days. Safety parameters, evaluated at each dose level, included measurement of total testosterone, free testosterone, dihydrotestosterone, estradiol, cortisol, thyroxin and insulin levels. Analyses for 7-oxo-DHEA-3beta-sulfate (DHEA-S), the only detectable metabolic product of the administered steroid, were conducted on plasma drawn from all subjects. The administered steroid was not detected in the blood but was rapidly converted to 7-oxo-DHEA-S, the concentrations of which were proportional to dose. This steroid sulfate did not accumulate. The mean time to peak plasma level of 7-oxo-DHEA-S was 2 hours; the mean half life was 2 hours.

    A. Over decades of review of nutritional studies I have come to realize the significant shortcomings that occur in safety studies due to several possible factors: The researchers did not look specifically for certain side effects, the patients did not report them, the researcher was supported by the company whose product is being tested and hence positive results are promoted and negative outcomes minimized (this occurs more often than people realize). For instance studies with DHEA rarely mention hair loss or heart rhythm disturbances but this occurs quite frequently among users. I find that the best way to evaluate the benefits and side effects of medications and nutritional supplements is to review the published research, take account my own experiences and feedback from patients, and read the emails I get from people who have used these products. Relying on studies alone does not provide the full picture.

Decline in levels with age
Excretion of testosterone, epitestosterone, androstenedione and 7-ketodhea in healthy men of different ages
Probl Endokrinol. 1979.
Urinary excretion of testosterone, epitestosterone, androstendion, and 7-keto-dhea was studied in 34 healthy men, aged from 20 to 72 years. The maximal excretion of these steroids and observed in men, aged between 20 and 30 years; their reduction was noted with the advance of age.

Endocrine gland and release influence
I have purchased your book Mind Boosters. I am a registered pharmacist and I would like to know what effects 7 Keto DHEA have on the HPA (Hypothalamus - Pituitary - Adrenal) axis. I lift weights and do aerobic conditioning. I fully appreciate your cautions regarding steroid hormone products. If a person were to take your recommended dose of 5 mg 7-Keto DHEA 2-3 times a week, does that dosage regimen appreciably affect the HPA axis as I don't want to affect the mineralocorticoids and glucocorticoids pathways.
   It is very difficult to predict the effect of exogenous hormones since, to find out, lots of blood tests for various hormones have to be done throughout the day for several days and weeks. Practically speaking it is best to avoid tests and just use low doses with frequent breaks and use alternatives to hormones when possible. Using 5 mg 2 or 3 times a week seems safe, especially if a full week is taken off each month.

Research studies
This article was published in Medical Hypotheses, a journal that writes about hypotheses that sometimes are accurate, and other times aren't.
7-oxo-DHEA and Raynaud's phenomenon. Texas A&M College of Medicine, College Station, USA.
We suggest that an ergogenic (thermogenic) steroid, 7-oxo-DHEA, which is available without prescription as the trademarked 7-keto DHEA, may be very helpful in prevention of primary Raynaud's attacks by increasing the basal metabolic rate and inhibiting vasospasm.

Use with other herbs, nutrients and aphrodisiac plants
Can 7 keto dhea be taken with tongkat ali herbal sexual enhancing plant?
   We don't suggest taking them the same day due to overstimulation and possible heart rhythm problems and increased body temperature.

I take 5-htp supplement for mood stabilizing and was wondering if taking a 7 keto-dhea pill with it may influence the effect.
   It probably will, but it is difficult to predict any one person's reaction.

I understand the use of Coq10 for more energy, and i understand also that 7keto gives more energy. I find that 30 or 50 mg of CoQ10 taken together with the hormone is fine for me, but when I take 100 mg of the CoQ10, I get too restless and irritable.

Emails and correspondence
I regularly look at your site for reference. I have taken DHEA for many years with benefit. When I had severe chronic fatigue syndrome, I took DHEA back inthe mid-90's and it gave me my life back. I do get blood tests taken to see ifit breaking down into other hormones. I was taking DHEA, pregnenolone and 7-Keto DHEA. I would call the dosages conservative but beyond what Dr. Sahelian recommends. I wanted to wean off the DHEA and take just the 7-Keto. I had blood tests taken in Sept 2013. My estradiol level was beyond the normal range (57.9). I never had a reading that high. I cut all dosages in half, but my highest dosage was the 7-Keto. I had blood taken again on Feb. 5, 2014. My total testosterone came back higher after cutting the DHEA and pregnenolone in half ! My estradiol increased to 62.2 Ifthe increases were due to DHEA and pregnenolone which I cut the dosage in half, I would think the total testosterone and estradiol would decrease. My DHEA-S decreased nicely to a comfortable level, actually the best reading that I have ever had. Everything that I have been told or read is that 7-Keto does not increase testosterone or estradiol. I was told this directly also by Humanetics who holds the patent on it. I sincerely have my doubts. I no longer use any of these. I could do a washout period and try the 7-Ketoalone and see what it does, but I don't want to be a human guinea pig. I do have a hunch that 7-Keto does have the ability to increase testosterone and estradiol, but I don't think it reconverts back to DHEA.

I play college football and almost everyone is on something that's just barely legal. I normally just take multi vitamins, creatine, and protein powder but lately ive been doing some research on other supplements that i could take. first and foremost i want to take something that's safe. I want to increase my strength and muscle mass. I've looked on certain body building web sites and they talk about how great dhea is but i'm not the type of person to just read one great review and go out and buy a supplement. I've also been doing some research into ZMA and tribulus and they seem a lot safer. Are there any supplements out there that can help me? I train hard and i play hard it just seems like i cant keep up with the other guys who are on all types of supplements and im on an athletic scholarship and i fear i might lose it if I cant step up my game.
   To the best of my knowledge creatine and protein supplements are the best options, along with getting a deep sleep at night. I am not convinced that over the counter hormones are safe or beneficial in the long term for athletic performance. I am not a sport performance enhancement expert, and hence do not know other potential 'secrets' that others may have who have studied this field in more detail. As I come across more information on athletic performance, I will update this site.

I recently came across advertisement for Metabospa. Can you tell me if it is safe? We had a press release sent to us that said this: TRIMSPA recently announced the introduction of its newest product, METABOSPA, a non-hoodia based weight loss supplement containing METABONEX (7-oxo DHEA). 7-oxo DHEA is a thermogenic, clinically proven ingredient, supplied by Humanetics, which promotes weight loss by increasing metabolism without the use of stimulants. Metabonex, the key ingredient, enhances the activity of three thermogenic enzymes – Glycerol-3-phosphate dehydrogenase, Malic Enzyme and Fatty Acyl CoA Oxidase – which promote the burning of body fat. In two independently conducted clinical trials, the effectiveness of Metabonex for weight loss was supported; specifically, that it promotes more weight and fat loss than diet and exercise alone. Both trials were double-blinded and placebo-controlled and have been published in peer-reviewed journals. 7-oxo DHEA is naturally found in humans and is known to decline with age, as does the body’s metabolic rate. The physiological effects associated with this decline include decreased activity of fat-burning enzymes, a significant decrease in basal metabolic rate and subsequent weight gain. Metabonex, which is protected by several U.S. patents, increases these levels and induces thermogenic enzymes at multiple levels to promote caloric efficiency. “Many people find that it’s hard to lose weight the older they become, even after they’ve reduced calories and started to exercise more,” said Scott Steil, Vice President of Sales & Marketing for Humanetics Corporation. “In fact, many consumers find that they need something more to jumpstart their metabolism as they get older but are cautious about stimulant-based ingredients. METABOSPA is non-stimulant based, and provides a safe and effective weight loss option for today’s weight conscious consumer.”
   I am not sure if Metabospa is effective, but I am concerned about regular ingestion of hormones such as 7keto dhea. I think it is premature to claim Metabospa is safe since I have not seen any long term human studies done with this product.

On surfing the internet the other day I came across a website that stated that 7 keto was a 'scam'. I have always believed the literature that it was an advance on DHEA in terms of its no side effects. I am confused by this revelation.
   I would not use the term scam for 7 keto DHEA. It's just that human research is quite limited with this hormone and there should be a good reason to use it since there are many alternatives to hormones depending on what medical condition is being treated.

I took 7 keto DHEA 25mg on and off for over 2 years. Recently I have been found to have a slightly dilated heart. Could this have been caused by it? I am also overweight and have borderline raised blood pressure.
   It is not possible for me to know whether its use was a direct cause or a contributing cause. Hypertension, itself, can cause a dilated heart... so can obesity.

Can you reference any specific medical findings that support your position that it is probably unsafe for a "normal" adult (I.e., not suffering from Adrenal Insufficiency, etc.) to take in excess of 5 mg 7 Keto DHEA per day? I have looked at countless research materials and they are all generally supportive of 25 to 50 mg per day for a healthy adult, with exceptions indicated for potential adverse side effects such as those with heart related conditions, thyroid disorders (specifically hyperthyroid), bone related disorders, etc.
    Those who claim that supplementation with a hormone is safe are the ones who have the responsibility to prove its safety through extensive published trials. I have not seen any studies regarding the long term safety of this hormone used by humans over several years of intake. For a long time doctors assured patients that hormone replacement with estrogen and progesterone was safe, and it took several decades for the adverse effects to be revealed. In my opinion, the daily use of any hormone supplement for years and decades is unsafe until conclusively proven otherwise through studies over several decades. Those who wish to take this hormone anyway, without such proof, are free to do so as long as they are aware of the paucity of information regarding its long term safety.

I am very concerned for my safety after having taken 7-keto in dosages ranged from 50mg to 300mg, not necessarily every day, but sometimes every few days, over the course of about 6 months. There have been drastic changes for better and worse that make me highly doubt its safety. 7-keto was the only new factor in my supplement regimen that I believe could have caused this. The other supplements I took at the time included blue green Kalmath algae, whey protein, multi vitamins, resveratrol, and occasionally colloidal gold. The problems I have now are :Left brow bone has grown noticeable larger than the right. Also, the left side of my face seems a bit fuller than my right (when i pinch my left cheek, there seems to be more fat there too). I'm worried that this could be a sign of a tumor or stroke. Also, I have started to use more of my left hand more naturally lately. Increased facial hair growth. Not just normal hairs (i have brown hair), but hairs that shine golden in the sunlight. The new facial hairs, especially around my upper and lower lip are exceedingly sharp! Sometimes when i rub my bare lips along my lower lip (when there's 2 days of hair growth), It feels like needles poking into me! Well I did put on muscle mass, and my shoulders have become broader. I also now have an enlarged heart.
   It's difficult to predict whether the over the counter hormone was the cause of these symptoms and signs, but it is possible.

I have been taking 7-KETO for 10 years at 25mg per day because I thought it would help ward off effects of "old age", i.e. wrinkles, weaker muscle tone, etc. Recently my blood pressure has been increasing. All through my life my blood pressure was on the low side until menopause when it increased to normal levels. I am a 66 yr old female. A few days ago I decided to stop taking it after reading your webpage. As a follow-up, I did not have any withdrawal symptoms nor have I noticed an improvement in my blood pressure.

7-oxo-DHEA (3-acetoxyandrost-5-ene-7,17-dione, also spelled 7 dhea oxo), is available without a prescription.