DHEA 5 mg, 60 capsules - Club Natural
FREE Diet Rx Bottle
7 Keto DHEA information
and supplement by
Ray Sahelian, M.D. Is 7 Keto DHEA safe?
7-keto DHEA is a hormone similar to DHEA. Proponents claim that 7-Keto DHEA cannot
be metabolized to active androgenic or estrogenic hormones but retains and enhances the
immunologic, memory-enhancing and thermogenic effects of DHEA. I find this hard
to believe. The same mechanisms and biochemical pathways that lead to the
7 keto DHEA benefit they claim, also are involved in causing 7 keto dhea side effects. I will hold
this viewpoint regarding 7-keto DHEA until I am shown evidence to the contrary. If
7 keto dhea has testosterone like benefits, it is likely that certain 7 keto DHEA side
effects will be due to androgen excess.
I am concerned that many people are misusing hormones such as
pregnenolone and
DHEA, 7-keto DHEA, and other
androgen-like products. Some people are taking dosages that are too high or they
are taking these hormones when they really do not need them. A 7 keto DHEA user, and other hormone users may, in the future, regret having taken high amounts
of these hormones for prolonged periods. Smaller amounts of 7-keto DHEA may be
appropriate to use for specific purposes and for for a limited time as long as your health care provider
approves. For this reason we have made a 7-keto DHEA supplement available.
7 Keto DHEA
alternatives
If you are planning to use 7-keto DHEA for the purposes of weight
control, consider a safer alternative called Diet Rx which is a powerful
appetite suppressant without hormones. For sexual enhancement, consider Passion
Rx which works extremely well. For mental enhancement, consider Mind Power Rx.
NOW Foods 7
Keto DHEA 25 mg per capsule
DHEA 5 mg,
60
capsules - Club Natural
FREE Diet Rx Bottle
Click here if you would like to buy 7-Keto-DHEA supplement, DHEA supplement 5 mg, FREE Diet Rx appetite suppressant, Passion Rx sex booster, Mind Power Rx brain booster, or information on hundreds of high quality natural supplements. You can also sign up for a FREE supplement newsletter.
Diet Rx is formulated to help you eat less. It really works. Click the link above. Diet Rx does not have DHEA or 7 keto DHEA.
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Supplement Research Update newsletter.
Twice a month we Email you a
review of
several new studies on various supplements and natural medicine topics and their
practical interpretation by Ray Sahelian, M.D.
We will mention research updates on 7 keto DHEA when human studies are published.
DHEA instead of
7 Keto DHEA
Those who do not wish to use 7-keto-DHEA also have the option of regular DHEA in 5 mg doses. Higher amounts -- for instance the most
common dose sold is 25 mg -- should only be taken under medical supervision and
only for brief periods, unless you have adrenal failure and need full
replacement of adrenal hormones.
Passion
Rx--- Medical Doctor formulated
for men and women
Passion Rx is a bestseller
Passion Rx is an herbal supplement that supports healthy stamina, sensation, and
sexuality in men and women, along with satisfying erections and
orgasms/climaxes. Passion Rx does not have DHEA or 7
keto DHEA.
In recent years science has made breakthroughs in
the understanding of sexual dysfunction. But, for hundreds of years,
civilizations around the world have known about locally grown herbs that achieve
wonderful results with far fewer side effects than prescription drugs.
Now, renowned physician and herbal
expert Dr. Ray Sahelian, M.D., author of Natural Sex Boosters, has
discovered a combination of exotic herbs from the Amazon jungle, India, China,
Malaysia, and Africa, that support healthy desire and performance, as well as to
simply enhance sexual pleasure. Passion Rx provides a
natural solution for those looking for an alternative to synthetic drugs.
The potent herbal extracts in Passion Rx include
Ashwagandha, Catuaba, Cnidium,
Damiana, Horny goat weed, Maca,
Muira puama, Passion flower,
Tribulus terrestris, and
Tongkat ali. A version
of Passion Rx has yohimbe.
7- keto DHEA side
effects
As with DHEA and pregnenolone, the most serious potential 7-keto dhea
side effect is heart palpitations.
Q. You are right to be cautious regarding 3-Acetyl-Oxo-Dehydroeplandrosterone (7-ketodhea) marketed under the name PatentLean. My husband purchased 3 bottles of this product over the counter in the United States. I read the bottle, and unfortunately believed the marketing hype of it being "effective, trusted and that clinical results showed no negative side effects when used as directed". After approximately one week of following the manufacturers instructions of taking 2 capsules a day of 100mg, I started to suffer palpitations and intense headaches. My husband who is usually very good natured, became bad tempered and aggressive in his attitude. After researching this product more fully, during which I discovered your dhea website, I was appalled that the product claims are based on very little scientific evidence. We stopped taking the product immediately, and all of the symptoms have disappeared. I hope this information will be of value to you and your readers. Your website is of great public service. You are indeed correct when you advise people to do their own research regardless of the credentials of the person or persons making any claims.
Q. Last year I consulted a private nutritional
doctor, because I felt my lack of energy might be related to borderline thyroid
function. I was prescribed thyroxine, and also advised to take 7 keto DHEA 25 mg
for adrenal support. Certainly my sex drive increased on this regime. Some
months later, I was advised to increase to 50mg daily but after a while began to
develop facial hair, mostly in the moustache area. My private dr advised me to
stop taking the 7 keto, but several months later, I still have the increased
facial hair, and seem to have experienced some change of sexual identity in my
reactions to seeing people of my own sex - I have never experienced this before.
I'm happily married, and have found this quite disturbing. Is this an experience
which has been reported before? It certainly seems like a drug that shouldn't be
freely available, if it can have such powerful effects.
A. Hormones, such as 7keto dhea and dhea are powerful substances and I have, for
many years, asked the nutritional supplement industry to keep dosages over the
counter to 5 or 10 mg and to warn people not to take these hormones daily
without breaks. Being more sexual can tilt some individuals towards being
attracted to both sexes, and potentially the hormones may trigger certain areas
in the brain to be attracted to a member of the same sex.
Alternatives to hormones
Hormones provide benefits that may also be available in less dangerous
ways. Here are some alternatives you may wish to explore:
For sexual enhancement, there are many herbs and nutrients that are helpful. See
the book Natural
Sex Boosters for a detailed discussion or scroll down for Passion Rx, a
libido product formulated by Dr. Sahelian that works in men and women.
For bigger or more toned muscles, see
Creatine.
For more stamina - see
Energy. MultiVit Rx is a
comprehensive formula that enhances natural energy.
Anti-aging - see
Longevity
For better blood sugar control -
Diabetes
7-Keto DHEA summary by Ray Sahelian, M.D.
I am not aware of 7 keto DHEA human studies of any significance. Therefore, no recommendations can be made at this time
except to say that I do not feel comfortable with the high dosages of 7-keto DHEA and DHEA sold over the counter. I think a maximum of 5 mg is acceptable.
Hormones are powerful substances that have significant short and long term
effects. They can be very helpful if used appropriately but can cause serious
harm if misused in high doses. DHEA has sexual enhancement
properties. I do not know if
7-keto DHEA has the same effect.
High Quality products without DHEA or
7-Keto DHEA, formulated by a
medical doctor
Consider highly popular all natural herbal products formulated by a world famous
medical doctor, Ray Sahelian, M.D. These include
Mind Power Rx for mental focus, concentration, and mood; Diet Rx which helps you eat less; Good Night
Rx with 5-HTP and melatonin for better sleep; Eyesight
Rx for better vision; MultiVit
Rx a daily comprehensive multivitamin for more energy and
vitality; Joint Power Rx
for healthy joints; Prostate Power Rx
for a healthy prostate gland; Passion Rx
for sexual enhancement in men and women; and
Veg Rx which supplies the missing nutrients in a vegetarian
diet.
7-Keto DHEA
Research Update
Prohormones and sport.
J Steroid Biochem Mol Biol. 2002 Dec;83(1-5):245-51.
Several precursors of testosterone and nandrolone introduced on the
nutritional supplement market as performance enhancing drugs are banned in
sports. Until now they are legally sold without a prescription in the US.
Results of excretion studies with related compounds including 7-keto-DHEA and
1-androstenediol are presented. The main metabolites of 7-keto-DHEA are
7-hydroxylated compounds. The commercial 1-androstenediol preparation was
contaminated with several other anabolic steroids. Oxidation of 1-androstenediol
to 1-androstenedione seems to be the major renal metabolic pathway. Additionally
contaminated nutritional supplements containing banned substances not indicated
on the label were administered. The results of the excretion studies indicate
that after the intake of amounts substantially lower than the recommended dose
athletes can fail a doping test for periods up to 120 h.
This article was published in Medical
Hypotheses, a journal that writes about hypotheses that sometimes
are accurate, and other times aren't.
7-oxo-DHEA and Raynaud's phenomenon.
Ihler G, Chami-Stemmann H.
Texas A&M College of
Medicine, College Station 77843, USA.
Patients with Raynaud's phenomenon have abnormal digital vasoconstriction in
response to cold. The pathogenesis remains unknown but may involve a local
neurovascular defect leading to vasoconstriction. Diagnosis of primary Raynaud's
phenomenon is based on typical symptomatology coupled with normal physical
examination, normal laboratory studies and lack of observable pathology by nail
fold capillaroscopy. Secondary Raynaud's phenomenon is known to occur associated
with several connective tissue diseases, vascular injury due to repeated
vibrational trauma, and other causes which produce demonstrable vascular and
microcirculatory damage. Treatment of Raynaud's symptoms is conservative and
aimed at prevention of attacks. Patients are advised to remain warm and, if
possible, to live in warm climates. We suggest that an ergogenic (thermogenic)
steroid, 7-oxo-DHEA (3-acetoxyandrost-5-ene-7,17-dione), which is available
without prescription as the trademarked 7-keto DHEA, may be very helpful in
prevention of primary Raynaud's attacks by increasing the basal metabolic rate
and inhibiting vasospasm.
Excretion of testosterone, epitestosterone,
androstenedione and 7-ketodhea in healthy men of different ages
Probl Endokrinol (Mosk). 1979 Jul-Aug;25(4):28-31.
Urinary excretion of testosterone, epitestosterone, androstendion, and
7-keto-dhea was studied in 34 healthy men, aged from 20 to 72 years. The maximal
excretion of these steroids and observed in men, aged between 20 and 30 years;
their reduction was noted with the advance of age.
7 keto dhea
dhea dosage fat keto loss.
7-Keto DHEA emails
Q. I have been taking 12.5mg daily of 7
Keto DHEA for a few months. My estrogen blood results have gone above the
recommend range. I have also been taking 300mg of Chryson during this period
which is meant to lower my Estrogen. Is it possible for 7 Keto DHEA to elevate
my estrogen? I've been told 7 Keto doesent break down into estrogen?
A.
Many claims are being made about 7-Keto DHEA that are not based on science.
Marketers are trying to make it seem like it has all the benefits of DHEA
without the side effects. We think they are not being forthright with the public
when they make claims like this. It is quite possible that 7-keto is being
converted into estrogens. This is one reason why we do not sell more than 5 mg
of DHEA, since it has untoward side effects on higher dosages. And we don't sell
7-Keto DHEA because we just don't know what it does in the body.
Q. I've been doing some
research on dhea and 7 keto dhea and i came across your website and your article
on dhea. I play college football and almost everyone is on something that's just
barely legal and im starting to feel that i cant compete as well as i used too,
i normally just take multi vitamins, creatine, and protein powder but lately ive
been doing some research on other supplements that i could take. first and
foremost i want to take something thats safe,and i want to increase my strength
and muscle mass. ive looked on certain body building web sites and they talk about how great
dhea is and i thought that it might be what i'm looking for but i'm not the type
of person to just read one great review and go out and buy a supplement i like
to know what im putting into my body and if it has any long term side affects
and well the more research ive done the worse dhea looks. ive also been doing
some research into zma and tribulus and they seem a lot safer but anyways what
id like to know is, are there any supplements out there that can help me? i dont
want to seem like a complainer or that im taking the easy way out by
taking supplements, i train hard and i play hard it just seems like i cant keep
up with the other guys who are on all types of supplements and im on an athletic
scholarship and i fear i might lose it if i cant step up my game.
A. To the best of my knowledge, creatine and protein
supplements are the best options, along with getting a deep sleep at night. I am
not convinced that over the counter hormones are safe or beneficial in the long
term for athletic performance. I am not a sport performance enhancement expert,
and hence do not know other potential 'secret' that others may have who have
studied this field in more detail. As I come across more information on athletic
performance, I will update this site.
Q. Does the FDA allow 7 keto DHEA to be sold over the counter?
A. Yes. FDA has not banned 7 keto DHEA.
Q. 7 keto dhea gives me tachycardia.
A. Yes, dhea can give rapid heart beat, too. However, this is dose
dependent. Usually dosages 5 mg or less do not cause tachycardia.
Q. Hello Dr. Sahelian, I have purchased your book
Mind boosters and researched your website. I am a registered pharmacist and I
would like to know what effects DHEA and 7 Keto DHEA have on the HPA
(Hypothalamus - Pituatary - Adrenal) axis. I lift weights and do aerobic
conditioning. I fully appreciate your cautions towards DHEA and other steroid
hormone products. If a person were to take your recommended dose of 5 mg 7-Keto
DHEA 2-3 times a week, does that dosage regimen appreciably affect the HPA axis
as I don't want to affect the mineralcorticoids and glucocorticoids pathways.
Any suggestions would be welcomed as I have gained much from your book and
website.
A. It is very difficult to predict the effect of
exogenous hormones such as 7 keto dhea since, to find out, lots of blood tests for
various hormones have to be done throughout the day for several days and weeks.
Practically speaking it is best to avoid tests and just use low doses with
frequent breaks and use alternatives to hormones when possible. Using 5 mg 7 keto dhea 2 or 3 times a week seems safe, especially if a full week is taken off
each month.
Q. I recently came across advertisement for Metabospa.
Can you tell me if Metabospa is safe?
A. We had a press release sent to us that said this: TRIMSPA recently announced the introduction of its newest product, METABOSPA,
a non-Hoodia based weight loss supplement containing METABONEX (7-oxo DHEA).
7-oxo DHEA is a thermogenic, clinically proven ingredient, supplied by
Humanetics, which promotes weight loss by increasing metabolism without the use
of stimulants. METABONEX, the key ingredient, enhances the activity of three
thermogenic enzymes – Glycerol-3-phosphate dehydrogenase, Malic Enzyme & Fatty
Acyl CoA Oxidase – which promote the burning of body fat. In two independently
conducted clinical trials, the effectiveness of METABONEX for weight loss was
supported; specifically, that it promotes 3 times more weight and fat loss than
diet and exercise alone. Both trials were double-blinded and placebo-controlled
and have been published in peer-reviewed journals. 7-oxo DHEA is naturally found
in humans and is known to decline with age, as does the body’s metabolic rate.
Published studies show that 7-oxo DHEA levels drop by nearly 50% between the
ages of 20 and 40, and further decline to negligible amounts by age 70. The
physiological effects associated with this decline include decreased activity of
fat-burning enzymes, a significant decrease in basal metabolic rate and
subsequent weight gain. Metabonex, which is protected by several U.S. patents,
increases these levels and induces thermogenic enzymes at multiple levels to
promote caloric efficiency. “Many people find that it’s hard to lose weight the
older they become, even after they’ve reduced calories and started to exercise
more,” said Scott Steil, Vice President of Sales & Marketing for Humanetics
Corporation. “In fact, many consumers find that they need something more to
jumpstart their metabolism as they get older but are cautious about
stimulant-based ingredients. METABOSPA is non-stimulant based, and provides a
safe and effective weight loss option for today’s weight conscious consumer.”
I am not sure if Metabospa is effective, but I am
concerned about regular ingestion of hormones such as 7keto dhea. I think it is
premature to claim Metabospa is safe since I have not seen any long term human
studies done with this product. If you do plan to take it, try a portion of a
pill.
Q. I recently read your article on the safety of 7-keto DHEA where you stated that "If 7 keto dhea has testosterone like benefits, it is likely that 7 keto DHEA side effects are due to androgen excess." and "As of April 2006, I could not find 7 keto DHEA human studies of any significance on Medline." What are your thoughts regarding the following study? It appears to indicate no androgen buildup. Is this a chemically different metabolite than what we currently refer to as DHEA pr 7-keto-dhea?
Q. Thank You for your
informative web site about nutritional supplements. I was looking for info about
7-keto dhea - a health food store owner recommended trying DHEA for my tired and
achy problems- I had tried many things and nothing helped. I bought what he
picked for me. I started taking the product- about 3-5 days later I started to
notice discomfort on my left side chest and my heart rate seemed high, pulsing
through out my body, thought I should see a doctor for possible heart concerns.
When I looked at the product it was actually 7-keto dhea not DHEA. Researching
this product online I came across your site. You had posted an email from
someone who said 7-keto dhea had caused tachycardia from its use. I'm sure this
is what is happening to me. I am stopping its use immediately and never going to
that store again. I am angry at the store owner but happy to have found this
info online.
Safety and pharmacokinetic study with escalating doses of
3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers.
Clin Invest Med. 2000 Oct;23(5):300-10
To evaluate the safety and pharmacokinetics of 3-acetyl-7-oxo-DHEA
(3beta-acetoxyandrost-5-ene-7,17-dione) given orally with a randomized, double
blind, placebo-controlled, escalating dose study. Twenty-two healthy men
received placebo or 3-acetyl-7-oxo-DHEA at 50 mg/d for 7 days
followed by a 7-day washout; 100 mg/d for 7 days followed by a 7-day washout;
and 200 mg/d for 28 days. Safety parameters, evaluated at each
dose level, included measurement of total testosterone, free testosterone, dihydrotestosterone, estradiol, cortisol, thyroxin and insulin levels. Analyses
for 7-oxo-DHEA-3beta-sulfate (DHEA-S), the only detectable metabolic product of
the administered steroid, were conducted on plasma drawn from all subjects at
0.25, 0.5, 1, 2, 4, 6 and 12 hours after the final 100 mg dose of
3beta-acetyl-7-oxo-DHEA. There were no differences in the clinical
laboratory values or in reported minor adverse experiences, between treatment
and placebo groups. In general, blood hormone concentrations were unaffected by
the treatment with 3beta-acetyl-7-oxo-DHEA and remained within the normal range.
No changes in vital signs, blood chemistry or urinalysis occurred during
treatment with 3beta-acetyl-7-oxo-DHEA compared to placebo. The administered
steroid was not detected in the blood but was rapidly converted to 7-oxo-DHEA-S,
the concentrations of which were proportional to dose. This steroid sulfate did
not accumulate; plasma concentrations 12 hours after the 3beta-acetyl-7-oxo-DHEA
dose at 7 and 28 days on the 200 mg/d dose were 15.8 and 16.3 microg/L
respectively. The mean time to peak plasma level of 7-oxo-DHEA-S was 2.2 hours;
the mean half life was 2 hours. These results
indicate that 3beta-acetyl-7-oxo-DHEA is safe and well tolerated in normal
healthy men at doses up to 200 mg/d for 4 weeks.
A. It does not appear that this form of dhea is the same as dhea or
exactly the same as 7ketodhea. Long term side effects of hair loss or tumor
formation cannot be determined within a few weeks. I remain cautious on the use
of these hormones.
Q. Can 7 keto dhea be taken with
tongkat ali?
A. We don't suggest taking them the same day due to overstimulation
and possible heart rhythm problems and increased body temperature.
Q. On surfing the internet the other day I came
across a website that stated that 7 keto was a 'scam'. I have always believed
the literature that 7 keto was an advance on DHEA in terms of its no side
effects. I am confused by this revelation. I am sure that you have researched
this product.
A. We would not use the term scam for 7 keto DHEA. It's just that
human research is quite limited with this hormone and there should be a good
reason to use it since there are many alternatives to hormones depending on what
medical condition is being treated.
7-Keto DHEA supplement
7-oxo-DHEA (3-acetoxyandrost-5-ene-7,17-dione, also spelled 7
dhea oxo), is available without prescription as the trademarked 7-keto DHEA.
Additional links
androgens information
including testosterone benefit and risks
5-htp supplement for mood
stabilizing
coq10 for more energy
This 7 keto dhea page was last updated January 2008.