Hyaluronic acid is a component of synovial fluid, and is found in the vitreous humor of the eye, the synovia of joints, and in subcutaneous tissue where it functions is as a cementing agent. Hyaluronic acid is a glycosaminoglycan with anti-inflammatory and anti-edematous properties. In osteoarthritis, changes occur in the hyaluronic acid found in cartilage leading to degradation of the cartilage.

Hylauronic acid benefit claims
Hyaluronic acid oral supplements are promoted for arthritis and many other conditions including skin health.  I have come across one human study with an oral form of hyaluronic acid from chicken comb which showed some improvement in joint pain. Many studies have been conducted with hyaluronic acid in the injectable form into knees and I have listed some of them below. Some of the studies with the injectable form of hyaluronic acid directly into the joint show it to be effective, while others have not shown much benefit. As of May 2009, I am aware of one published study regarding the oral use of hyaluronic acid. As to injectable hyaluronic acid, the reports are mixed. Side effects are possible with hyaluronic acid, see below. 

Buy Hyaluronic Acid, 50 mg per pill
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Hyaluronic acid plays an integral role in maintaining and regulating moisture with the tissues and facilitates the transport of nutrients into the cells and the removal of metabolic waste. Hyaluronic acid is found in all of the body's tissue, with the highest concentrations located in the extracellular matrix of the skin and the synovial fluid that bathes the joints and cartilage. Optimum levels of hyaluronic acid are essential for the health of the joints and cartilage. Hyaluronic acid has undergone a natural enzyme cleaning technique for greater absorption. Whether hyaluronic acid ingested as a pill is able to easily enter joint tissue is not clear at this time.

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Hyaluronic acid Supplement Facts
Hyaluronic acid 50 mg *

Suggested Use: 1 hyaluronic acid softgel once or twice daily with a meal.
Note: Side effect of rash has been reported to us by a few users of oral hyaluronic acid.

* Hyaluronic acid oral supplement daily value not established.

Joint Power Rx (does not have hyaluronic acid)
Formulated by Ray Sahelian, M.D.

Because joint pain is so debilitating, Glucosamine Sulfate and chondroitin alone are sometimes not enough. This powerful formula includes several additional herbal extracts and nutrients that play a role in joint health.  

Joint Power Rx Supplement Facts:
Glucosamine sulfate (from shellfish)
Chondroitin sulfate
MSM
CMO complex
Boswellia serrata extract
Curcumin
Cat's claw extract
Devil's claw extract
Grape seed extract
Sea Cucumber

Hyal-Joint supplement information
Hyal-Joint is a natural extract with a high content of oral hyaluronic acid (60 percent) plus other constituents such as collagen and glycosaminoglycans. It is promoted by BioIberica, a company in Spain. A small pilot study shows that it could help those with joint problems.

Effect of a natural extract of chicken combs with a high content of hyaluronic acid ( Hyal-Joint ) on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trial.
Nutrition Journal. January. 2008.
Twenty subjects aged 40 years and older with knee osteoarthritis participated in a randomized double-blind controlled trial. Ten subjects received Hyal-Joint (80 mg/day) and 10 subjects received placebo for 8 weeks. This pilot clinical trial showed that daily supplementation with oral hyaluronic acid from a natural extract of chicken combs ( Hyal-Joint ) was useful to reduce body pain and to enhance several markers of quality of life in adults with osteoarthritis of the knee.
   Comments: Additional studies are needed to confirm the results of this pilot study. Plus, we don't know the influence of the other constituents found in this product versus the effect of hyaluronic acid itself.

Hyaluronic acid review summary
At this time I don't have a strong opinion on the oral form of hyaluronic acid since I have come across only one small study evaluating its effectiveness. There is no mention in the medical literature at this time that hyaluronic acid has side effects when used orally, however we have had reports from several users of a side effect with hyaluronic acid in form of a skin rash. If you wish to give it a try, a high quality hyaluronic acid product is made available to you above  For joint support consider other nutrients that play a role and have been studied more thoroughly, including glucosamine, chondroitin, MSM, or a combination of the above found in Joint Power Rx.

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Hyaluronic acid side effects, safety, allergy, caution
Since hyaluronic acid oral tablets are relatively a new introduction, side effects are not fully known. We have received a few emails by hyaluronic acid users that they experienced a skin rash. Caution is advised regarding hyaluronic acid use since we don't know much about the long term effects of this nutrient taken orally.

Have been using LubriSyn Hyaluronic Acid (Sodium) 150 mg for humans orally, for a couple of weeks and have noticed my skin breaking out, mostly on my forehead. Noticed too my face and forehead seem sort of oily. After about 5 or 6 days of not using the product, my skin is clearing up.

I am presently taking Hyauluronic Acid with OptiMSM. I seems to help the pain and stiffness in joints. However I have developed an itching on both lower legs. Can this be coming from Hyauluronic Acid with MSM? I plan to stop taking it for a couple of days and see what happens.
    It's not possible to say which supplement is causing this adverse event without taking time off and reintroducing one at a time, the HA and the MSM.

I appreciate your research on hyaluronic acid side effects which Google led me to. I haven't experienced a rash like others have, but have had an unusual reaction. I have been taking Synerflex (Northstar Nutritionals) for 3 months. I have had enormous good luck with it's ability to end pain in legs radiating from knee problems (which won't be fixed until surgery in two more months). My husband now takes it, too. I take two a day, usually with evening meal. He has just started taking it last month. I've also been recommending it to other people. Recently, I developed a furriness on my teeth that didn't go away with brushing, flossing, and ordinary mouth care. After using a Stimudent stick to clean between my teeth (after having brushed with electric toothbrush and flossing), the results were scary - a yellow substance came from between almost allmy teeth. My eyes had become excessively watery and had a cloudiness of vision at times. I was constantly clearing my throat. I decided to stop the Synerflex, it being the most recent addition to the supplements we take. Two days later, the furriness is gone and my breath smells sweeter; eyes are drier and vision has cleared up. Throat is less croupy. We live a very healthy lifestyle. I am concerned about these results and wonder if you have had any other complaints about Synerflex. Contents include Hyal-joint (60% min. HyaluronicAcid w/5% hydrolyzed collagen and 15% min other glucosaminoglycans totalling 60 mgs; Hops flower extract 500 mgs; Boswellia serrata extract 300 mg; Boron as calcium fructoborate 2.5mg;and bioenhancer blend of ginger root, black pepper, and long pepper 50mg. The jel-caps are filled with a yellow substance.
    This is the first I have heard of this kind of reaction. It is interesting and I will await to see if others have a similar reaction.

Source of hyaluronic acid supplements
Q. What is the hyaluronic acid supplement made from, or is it synthetic?
   A. A common, natural source for hyaluronic acid supplements is rooster combs but other sources are also available.

Q. What is the molecular weight range and the starting material of sodium hyaluronate from ingredient suppliers?
   A. Sodium hyaluronate is the sodium salt of hyaluronic acid, which is a straight chain macromolecular mucopolysaccharide composed of repeat disaccharide units of glucuronic acid and N-acetylglucosamine. The molecular weight from of one supplier of sodium hyaluronate, DNP international, is around 1-2 million Daltons and it is derived from glucose fermentation.

Hyaluronic Acid Research study
Hyaluronic acid: a unique topical vehicle for the localized delivery of drugs to the skin.
J Eur Acad Dermatol Venereol. 2005 May;19(3):308-18.
Hyaluronic acid is a naturally occurring polyanionic, polysaccharide that consists of N-acetyl-d-glucosamine and beta-glucoronic acid. It is present in the intercellular matrix of most vertebrate connective tissues especially skin where it has a protective, structure stabilizing and shock-absorbing role. The unique viscoelastic nature of Hyaluronic acid  along with its biocompatibility and non-immunogenicity has led to its use in a number of clinical applications, which include: the supplementation of joint fluid in arthritis; as a surgical aid in eye surgery; and to facilitate the healing and regeneration of surgical wounds. More recently, Hyaluronic acid  has been investigated as a drug delivery agent for various routes of administration, including ophtalmic, nasal, pulmonary, parenteral and topical. In fact, regulatory approval in the USA, Canada and Europe was granted recently for 3% diclofenac in 2.5% Hyaluronic acid  gel, Solaraze(R), for the topical treatment of actinic keratoses, which is the third most common skin complaint in the USA. The gel is well tolerated, safe and efficacious and provides an attractive, cost-effective alternative to cryoablation, curettage or dermabrasion, or treatment with 5-fluorouracil. The purpose of this review is to describe briefly the physical, chemical and biological properties of Hyaluronic acid  together with some details of its medical and pharmaceutical uses with emphasis on this more recent topical application.

Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis.
CMAJ. 2005 Apr 12;172(8):1039-43.
Osteoarthritis of the knee affects up to 10% of the elderly population. The condition is frequently treated by intra-articular injection of hyaluronic acid. We performed a systematic review and meta-analysis of randomized controlled trials to assess the effectiveness of this treatment. We searched MEDLINE, EMBASE, CINAHL, BIOSIS and the Cochrane Controlled Trial Register from inception until April 2004 using a combination of search terms for knee osteoarthritis and hyaluronic acid and a filter for randomized controlled trials. We extracted data on pain at rest, pain during or immediately after movement, joint function and adverse events. Twenty-two trials that reported usable quantitative information on any of the predefined end points were identified and included in the systematic review. Even though pain at rest may be improved by hyaluronic acid, the data available from these studies did not allow an appropriate assessment of this end point. According to the currently available evidence, intra-articular hyaluronic acid has not been proven clinically effective and may be associated with a greater risk of adverse events. Large trials with clinically relevant and uniform end points are necessary to clarify the benefit-risk ratio.

Hyaluronic acid for the treatment of knee osteoarthritis: long-term outcomes from a naturalistic primary care experience.
Am J Phys Med Rehabil. 2005 Apr;84(4):278-83; quiz 284, 293. Petrella RJ. Department of Family Medicine, University of Western Ontario, Ontario, Canada.
Intraarticular hyaluronic acid is indicated for patients with osteoarthritis of the knee. However, clinical experience, especially efficacy and adverse events, with repeated injection series in the long term are limited. DESIGN: Patients were referred to a large primary care center for management of osteoarthritis of the knee. All were naive to intraarticular hyaluronic acid therapy and met our entry criteria, including resting visual analog scale pain of > 45 mm, radiographic confirmation of unilateral knee grade 1-3 osteoarthritis, and willingness to receive intraarticular therapy. Patients received a three-intraarticular injection series with Suplasyn (10 mg/ml, 2-ml injection) over 3 wks. Intraarticular hyaluronic acid injections were highly effective in improving resting and walking pain in patients with osteoarthritis of the knee on a first and a second treatment series. Duration of symptom control was about 6 mos, and the therapy was highly satisfactory to patients and was associated with very few local adverse events and limited use of concomitant therapeutic modalities. These data support the potential role of intraarticular hyaluronic acid as an effective long-term therapeutic option for patients with osteoarthritis of the knee.

A double blind, randomized, multicenter, parallel group study of the effectiveness and tolerance of intraarticular hyaluronan in osteoarthritis of the knee.
J Rheumatol. 2004 Apr;31(4):775-82.
To investigate the efficacy and tolerability of a course of 5 injections of hyaluronan ( HA or hyaluronic acid ) given at intervals of one week in patients with symptomatic, mild to moderate osteoarthritis (OA) of the knee. A double blind, randomized, parallel group, multicenter (17 centers), saline vehicle-controlled study was conducted over 18 weeks. Patients received either 25 mg (2.5 ml) hyaluronic acid in a phosphate buffered solution or 2.5 ml vehicle containing only the buffer by intraarticular injection. Five injections were given at one week intervals and the patients were followed for a further 13 weeks. Of 240 patients randomized for inclusion in the study, 223 were evaluable for the modified intention to treat analysis. The hyaluronic acid treatment and control groups were comparable for demographic details, OA history, and previous treatments. Scores for the pain and stiffness were modestly but significantly lower in the hyaluronic acid -treated group overall and the statistically significant difference from the control was not apparent until after the series of injections was complete. The physical function subscale did not reach statistical significance. Tolerability of the procedure was good and there were no serious adverse events that were considered to have a possible causal relationship with hyaluronic acid. CONCLUSION: Intraarticular hyaluronic acid treatment was significantly more effective than saline vehicle in mild to moderate OA of the knee for the 13 week postinjection period of the study.

Intra-articular hyaluranic acid compared with progressive knee exercises in osteoarthritis of the knee: a prospective randomized trial with long-term follow-up.
Rheumatol Int. 2005 Mar 18; [Epub ahead of print]
The goal of this study was to determine whether hyaluronic acid or progressive knee exercises (PE) can improve functional parameters in patients with osteoarthritis (OA) of the knee. In a prospective clinical trial 200 knees (105 patients) with radiographic Kellgren Lawrence grade III OA were randomized and received either three intra-articular injections of hyaluronic acid (Hylan G-F 20) at one-week intervals or PE for 6 weeks. Patients were evaluated by use of the Hospital for Special Surgery (HSS) Knee Score and followed-up for 18 months. Total HSS score for hyaluronic acid and PE patients improved from 62.6+/-13.8 to 88.8+/-11.1 and from 65.4+/-12.3 to 88.3+/-9.1, respectively, at the end of the trial (P<0.01). There were no statistically significant differences between the groups. Twenty-one patients of the hyaluronic acid group were excluded from the study because they had received another form of therapy. All patients in the PE group completed the trial. The patients who dropped out had also significant improvement. This prospective randomized trial confirmed that both hyaluronic acid injections and PE result in functional improvement. Hyaluronic acid injections also increase the levels of satisfaction of the OA patients.

A one-year, randomised, placebo (saline) controlled clinical trial of 500-730 kDa sodium hyaluronate (Hyalgan, Hyaluronic acid) on the radiological change in osteoarthritis of the knee.
Int J Clin Pract. 2003 Jul-Aug;57(6):467-74.
The primary objective of this study was to investigate structural changes, as measured by joint space narrowing (JSN), within the knee joint during treatment with intra-articular sodium hyaluronate ( Hyaluronic acid ) of molecular weight 500-730 kDa in patients with osteoarthritis (OA) of the knee. Patients received a weekly intra-articular injection of either 20 mg2/ml Hyaluronic acid or a 2 ml vehicle placebo (saline) for three weeks. This course was repeated twice more at four-monthly intervals. Concomitant treatment with analgesics or NSAIDs was allowed. The primary efficacy measure was the reduction in mean joint space width (JSW) of the medial compartment at 52 weeks. A total of 408 patients were randomised and 319 completed the one-year study (Hyaluronic acid: n=160, placebo: n=159); 273 of the 319 were included in the primary analysis. Analysis of variance on these 273 patients did not show a statistically significant difference between the two treatment groups. However, there was a significant difference in response to treatment in terms of the baseline JSW (p=0.01), indicating that outcome of treatment may depend on-baseline JSW. Therefore, a subgroup analysis by baseline JSW was conducted. This compared patients with a JSW >4.6 mm with those with a JSW <4.6 mm. In those with radiologically milder disease at baseline and receiving Hyaluronic acid, the JSN was significantly reduced compared with placebo (p=0.02). In patients with radiologically more severe disease there was no difference in JSN between the two treatments. Although, in this one-year study, no overall treatment effect was seen, those with radiologically milder disease at baseline had less progression of joint space narrowing when treated with Hyaluronic acid.

Treatment of gingivitis with hyaluronan ( hyaluronic acid ).
J Clin Periodontol. 2003 Feb;30(2):159-64.
Hyaluronic acid (hyaluronan) is a glycosaminoglycan with anti-inflammatory and antiedematous properties. It was evaluated in a gel formulation for its effect in the treatment of plaque-induced gingivitis. METHOD: In a randomised double-blind study, 50 male subjects with plaque-induced gingivitis were divided into two groups and used a verum or placebo gel twice daily additionally to oral hygiene for a 3-week treatment period. Clinical indices (API, Turesky index, PBI) and crevicular fluid variables (peroxidase, lysozyme) were determined at baseline and after 4, 7, 14 and 21 days, respectively. Significant improvements could be found for all clinical variables in both groups. The Hyaluronic acid group showed significant improvement in the study area for the plaque indices beginning with day 4 and the PBI beginning with day 7in comparison with the placebo group. The crevicular fluid variables were significantly improved in the centre of the studied inflammation area in the Hyaluronic acid group. Here all studied sites had significant decreases in peroxidase and lysozyme activities after 7, 14 and 21 days, whereas in the placebo group only one site showed a significant decrease for lysozyme after 7 and 21 days. These data suggest that a Hyaluronic acid containing gel has a beneficial effect in the treatment of plaque-induced gingivitis.

Hyaluronic acid injection of the knees is no more effective than placebo. Arch Int Med 2002; 162:245-7.

Comparison of two hyaluronan drugs and placebo in patients with knee osteoarthritis. A controlled, randomized, double-blind, parallel-design multicentre study.
Rheumatology (Oxford). 2002 Nov;41(11):1240-8.
To compare the efficacy and safety of intra-articular injections of two different hyaluronan ( hyaluronic acid ) preparations and placebo in patients with knee osteoarthritis. In a randomized, patient- and observer-blind, placebo-controlled and multicentre trial with parallel groups, 210 patients, aged 60 yr or above, with knee osteoarthritis were included in a per protocol analysis. The patients were treated with three injections, once weekly, of either native high-molecular-weight hyaluronan (Artzal((R))) or cross-linked hyaluronan (Synvisc) or with placebo and were followed for 52 weeks. The primary efficacy measures were weight-bearing pain during study weeks 0-26 and the duration of clinical benefit measured with Kaplan-Meier survival analysis for weeks 0-52. The secondary outcome measures were resting and maximum pain, Lequesne index, WOMAC (Western Ontario and McMaster University Osteoarthritis Index) and SF-36 (Medical Outcomes Study Short Form Health Survey) scores. RESULTS: The intra-articular injections produced a significant reduction in weight-bearing pain, resting pain, maximum pain and Lequesne and WOMAC scores after 26 weeks. There were no significant differences in outcome between any of the three study groups during the first 26 weeks. In direct comparison against placebo for weeks 0-52, neither hyaluronan treatment (Artzal or Synvisc) showed a significantly longer duration of clinical benefit than placebo. However, when data for the two hyaluronan-treated groups were pooled, treatment with hyaluronan had a significantly longer duration of benefit compared with placebo (P = 0.047). CONCLUSION: Patients with knee osteoarthritis who were treated by injection into the knee of either of two hyaluronan preparations or placebo showed clinical improvement during the first 26 weeks of treatment, though neither hyaluronan preparation gave a longer duration of clinical benefit than placebo. However, when data for the two hyaluronan treatments were pooled, there was a significantly longer duration of clinical benefit for hyaluronan treatment than for placebo.

The FDA has ordered Hyalogic LLC to stop making unsubstantiated claims that its hyaluronic acid product, Synthovial 7, can increase cushioning, joint lubrication, and motility of painful arthritic joints.

Hyaluronan is an important structural element in the vitreous humor of the eye, synovial fluid, and skin of vertebrates. Moreover, hyaluron interacts with proteins such as CD44, RHAMM, and fibrinogen, thereby influencing many natural processes such as angiogenesis, cancer, cell motility, wound healing, and cell adhesion. Reflecting such a variety of functions, HA has attracted attention from a wide range of application fields such as medicine (including surgery), cosmetics, and health foods. Traditionally hyaluron was extracted from rooster combs, but nowadays is produced by the fermentation of streptococci. At present, quality issues such as purity and molecular weight distribution, rather than quantity, have been the focus of strain and process development in hyaluron production.

Hyaluronic Acid supplement emails
Q. I've been hearing a lot lately about hyaluronic acid for arthritis and skin. What is your opinion on hyaluronic acid supplements?
   A. At this time I don't have a strong opinion on the oral form of hyaluronic acid since I have not come across many studies evaluating its effectiveness for joints or skin. There is little mention in the medical literature at this time that hyaluronic acid taken orally has caused any significant side effects. For joint support consider other nutrients that play a role and have been studied more thoroughly, including glucosamine, chondroitin, MSM, or a combination of the above found in Joint Power Rx.

Q. I was doing some research for my mother-in-law who broke out in a chicken-pox-like rash. We can't figure any cause for the rash except I was looking up hyaluronic acid since she had begun taking that about two months before the rash broke out. I noticed that two people posted questions to you about this, so I thought I'd see if you have found out anything else.Her rash is not on her face but is bad on her arms, some on her legs and a few on her back and stomach. Since she stopped taking the hyaluronic acid about a week and a half ago, it is gradually getting better.

Q. I'm looking for people that are doing or have done research regarding hyaluronic acid. My mother, had the hyaluronic acid injected in her face approximately one year ago, and she has recently developed a reaction in her face. It feels as if the product had hardened inside her skin, she is very swollen and has redness around the area.

Q. I noticed one of your e-mails stating that someone who had been taking hylauronic acid orally for some time had a rash break out on his skin like chicken pox. I too had been taking hyaluronic acid for over two months when suddenly over the week-end my face developed a rash that looks like chicken pox? The rash is actually under the skin. Erie coincidence?
   A. Well, it looks like this is our second report regarding hyaluronic acid and skin symptoms, if we get a few more reports then it may be a serious issue to look into.

Q. I have taken many forms of hyaluronic acid orally for knee problems, they work very well but my skin broke out like I had chicken pox.  I know I cannot be allergic to the hyaluronic acid.
   A. We have had several reports of skin rash due to oral hyaluronic acid supplements.

Q. I got an allergic type rash / hives on the skin surrounding my hysterectomy surgical scar. Only on the abdomen.

Q. I have found that glucosomine and the like alone may not be sufficient for my pain. However if I use Hyaluronic acid and type ll collagen the relief may be rather fast. It seems the ligaments are easily irritated and can even make standing very difficult. But if I take the Hyaluronic acid it disappears rather quickly. I stumbled upon it one day, and wonder why more isn't done to give
people that information.

Q. I thought you might be interested to hear of a happy but unexpected side effect of Gengigel which has hyaluronic acid. I started to use the mouthwash when my dentist told me that I had severe gingivitis and that my gums would need a lot of attention. For some 50 years I have suffered from Psoriatic Arthritis and have been given virtually every possible treatment to counter its effects. Most of the treatments produced unwelcome side effects of one kind or another and I have had to discontinue virtually all of them. As a result I have, for many years, been taking Indomethacin as my main defence as it is the only drug that did not produce any side effects as far as I was concerned. However, it only had limited impact in damping down the inflammation. As a result I developed severe inflammation in both wrists and the right wrist has suffered bone damage as a result. I generally also suffer from pain in most joints as a result of the Psoriatic Arthritis which is very wearing on a day to day basis. My consultant gave me a quarterly, low dose shot of depomedrone to ‘damp down’ the general inflammation. I was just about due to have another quarterly injection at the time I started to use the Gengigel. A few days after starting to use the mouthwash I noticed that the general pain levels seemed to be reducing and that the swelling in my wrists and the pain in the joints had significantly reduced. I obtained some Gengigel Gel and started to apply this to my gums twice a day. Within two weeks the swelling in my wrists had totally disappeared. There was quite a large swollen lump on my right wrist and six weeks after starting to use Gengigel this has also subsided and my wrists look quite normal. It is a dramatic result in respect of the Psoriatic Arthritis and my Consultant is amazed. (By the way, the gingivitis has also disappeared.)
     A. We'll wait to see if this was coincidence or a real response to the gel.

Q. Was watching the horse racing network and one of the trainers was talking about a product that they are using on all their horses to help maintain their health and performance. The product is Lubrisyn which is a hyaluronic acid product that is given orally. The trainer said that they have reduced their injections by 1/2 and the horses seem to be holding up better than ever. Is this product or a similar product available for humans? I'm a 55 year old Professional Golfer and very interested in maintaining my joints.
     A. According to their website, "LubriSyn, Sodium Hyaluronate, is patented oral hyaluronic acid for the treatment of joint pain and inflammation. Hyaluronic acid is the same glycosaminoglican found in synovial fluid, and the cartilage matrices, which cushion and lubricate articulating joints. Supplemental HA improves soundness and joint function. Daily oral ingestion of HA avoids the peaks and valleys associated with injectable products by maintaining a consistent bio-available serum level. In a comparative study of five HA products in the treatment of traumatic arthritis in horses in athletic or race training, horses treated with HA of molecular mass greater than 2 million Daltons exhibited significantly longer durations of soundness than those treated with HA of molecular mass less than 2 million Daltons. Compared to alternatives, LubriSyn (Sodium Hyaluronate) has the highest molecular weight (2.4 million Daltons) for sustained joint function improvement."
      Now, I am not a vet and I am not familiar with research with horses. However, up to know, I have not seen studies in humans using hyaluronic acid in an oral form. When I searched Medline to find a published study in animals on LubriSyn, I could not find one. The website that sells LubriSyn mentions a study that they have done, but it does not say if the study was published in a veterinary journal. Therefore, at this time, unless the manufacturer can provide a published study regarding the benefit of LubriSyn, it may be premature to make claims about this joint health product. Plus, even if LubriSyn works, we are not sure if it is any better than glucosamine, chondroitin, or a combination of these nutrients and other joint supplements such as CMO and MSM.

Q. I have been taking 140 mg of hyaluronic acid supplement for 1 month and I noticed that the floaters in my eyes have turned from dark brown to clear with an overall reduction in all noticeable floaters. I do consume 4 oz of broccoli sprouts a day, and I have noticed that my night vision has dramatically improved.
     A. We would be interested to hear from other hyaluronic acid supplement users to see if this is a real benefit from the nutrient or whether the broccoli sprouts had an influence, or the combination, or pure coincidence.

Q. I have been having stiffness, binding, and pain in my neck for over a year now. If I were driving, watching TV or looking at a computer screen for a few minutes, I would lose mobility in my neck. To look down was very painful, my neck would bind until I would hear a very audible SNAP in my neck, and I would regain some temporary mobility. This has progressively gotten worse over the past 4 months or so, and the binding would happen maybe 40-50 times a day. I was beginning to think my neck was full of dry spaghetti.. A customer of mine introduced my to Hyalun, a horse supplement containing hyaluronic acid. I was very skeptical at first, researched the active ingredient and found no serious side effects from hyaluronic acid. I cannot believe how quickly and how well hyaluronic acid has worked for me. Literally, 3 days into the regiment, I had full mobility in the neck and haven't had it bind, snap, or crack once.
   A. That's great. Keep us updated to potential hyaluronic side effects or further benefits.

Q. I came across your website while looking for some hyaluronic acid to buy. I have been using hyaluronic acid for approximately three years. I saw a clip in the Star magazine about how it helped skin. I didn't find a lot for sale at that time (2003) but purchased some Injuv, from someone, can't remember. I used to wear glasses to see up close and distance. I used to have burning in my hip joints. I used to have really bad allergies. After using hyaluronic acid for a few months I noticed I could see without my glasses. I also noticed the burning in my hips disappeared. My skin always looked good because I spend a fortune on it, (ha, ha - I am 59 years old), so I haven't seen much change there. But I live on a ranch with hundreds of cattle, horses, cats, dogs, chickens and peacocks. I sneeze every so often but the dust and hay and other stuff (we have no paved roads) do not seem to bother me like it used to. I have told others about hyaluronic acid, my mother (she is 82) thinks it helps her skin. I KNOW it helps me. I am on a horse working cattle (sometimes 8 hours a day) and I think this helps me stay pain free. Let's see, I don't always buy the same brand. I try to get the most mg. 100 to 140mg. And I take two or three a day. My boyfriend was at Kaiser recently with a knee problem. He has horrible arthritus and when I mentioned hyaluronic acid the doctor said studies have not proven the absorption of hyaluronic acid in the body. But I can certainly tell you that it works for me. I know my body so I know when the changes took place and what changed. Anyway, just thought I'd share that information with you.

Q. I found your website looking for information about hyaluronic acid after hearing about its benefits for joints from a horse veterinarian, who uses it a lot for joint problems in sport horses. After having two years of knee pain and arthroscopic surgery that helped only marginally and temporarily, I tried taking hyaluronic acid orally. I've now been pain-free for 3 months. Going down stairs used to be painful, but now I can take them two-at-a-time again. Moreover, some minor pain in both hips and one shoulder disappeared at the same time. I use a liquid form of hyaluronic acid (Synthovial Seven) and take it under my tongue so that it doesn't go through my digestive system. (When I took it as directed by swallowing it with water, its benefits disappeared, but they returned when I went back to the under-the-tongue method. Weird, but true. Moreover, I've had chronic voice problems for years, and taking the hyaluronic acid seems to be helping that as well as my skin. It's a minor miracle.

Q. I'm looking to purchase hyaluronic acid injection to the knee joints. I think two hyaluronic acid products available, hyaluronan and hylan G-F 20, Five different brands of hyaluronan are available: Euflexxa, Hyalgan, Orthovisc, Supartz, and Synvisc.
   A. Hyaluronic acid injection require a medical doctor's prescription and a qualified medical doctor to do the injection.

Q. A couple of years ago, my wife tried an oral hyaluronic acid supplement. I don't remember the brand. But a couple of weeks after she developed a Baker's Cyst, which she never had before. I contacted the company and they said to discontinue the HA supplement. Have you heard of this possible connection as a side effect? Can a similar side effect occur with hyaluronic acid injections?
   A. I have not heard of a Baker's cyst associated with oral hyaluronic acid ingestion. As to hyaluronic acid injections, I do not have enough experience to know for sure.

Side effects of hyaluronic acid