Acetylcholine neurotransmitter increase with natural supplements by Ray Sahelian, M.D.  How to Increase Acetylcholine levels

Supplements such as choline and CDP-choline raise levels of acetylcholine. They are both available without a prescription. Choline is an essential precursor to acetylcholine, a stimulatory neurotransmitter. It also helps in the production of lipotropic agents which converts fats into useful products and aids in the production of HDL (good) cholesterol.    

Acetylcholine chemistry
Once produced, acetylcholine is stored in brain cells and released into the synaptic cleft upon stimulation. When released into the synaptic cleft, the enzyme acetylcholinesterase breaks acetylcholine back down into choline and acetyl. In Alzheimer’s disease, there is a shortage of acetylcholine, and one of the ways doctors have tried to increase the levels of this neurotransmitter is by prescribing drugs, such as tacrine and galantamine, that inhibit the enzyme acetylcholinesterase. An alternative to these drugs, a Chinese herbs extract called huperzine A, can also inhibit this enzyme. Galantamine is now available without a prescription.

Acetylcholine Research Update
Proof of the mysterious efficacy of ginseng: basic and clinical trials: suppression of adrenal gland medullary function in vitro by ginseng.
J Pharmacol Sci. 2004 Jun;95(2):140-4.
The root of Panax ginseng C.A. MEYER has been reported to have an anti-stress action. Therefore, the effects of ginseng components on functions of adrenal medulla, which is one of the most important organs responsive to stress, were investigated in vitro. First, the components of ginseng were mainly divided into two fractions, that is, the saponin -rich and non-saponin fractions. The saponin-rich fraction greatly reduced the secretion of catecholamines from bovine adrenal chromaffin cells stimulated by acetylcholine, whereas the non-saponin fraction did not affect it at all. The protopanaxatriol-type saponins inhibited the Acetylcholine-evoked secretion much more strongly than the protopanaxadiol-type. On the other hand, the oleanane-type saponin, ginsenoside-Ro, had no such effect. Recent reports have demonstrated that the saponins in ginseng are metabolized and absorbed in digestive tracts following oral administration of ginseng. All of the saponin metabolites greatly reduced the Acetylcholine-evoked secretion. M4 was the most effective inhibitor among the metabolites. M4 blocked Acetylcholine -induced Na(+) influx and ion inward current into the chromaffin cells and into the Xenopus oocytes expressing human alpha3beta4 nicotinic Acetylcholine receptors, respectively, suggesting that the saponin metabolites modulate nicotinic Acetylcholine receptors followed by the reduction of catecholamine secretion. It is highly possible that these effects of ginsenosides and their metabolites are associated with the anti-stress action of ginseng.

Acetylcholine -induced vasodilation is mediated by nitric oxide and prostaglandins in human skin.
J Appl Physiol. 2005 Feb;98(2):629-32.
Acetylcholine can effect vasodilation by several mechanisms, including activation of endothelial nitric oxide synthase and prostaglandin (PG) production. In human skin, exogenous acetylcholine increases both skin blood flow (SkBF) and bioavailable nitric oxide levels, but the relative increase is much greater in SkBF than nitric oxide. This led us to speculate acetylcholine may dilate cutaneous blood vessels through PGs, as well as nitric oxide. We conclude that a portion of the vasodilation effected by exogenous acetylcholine in skin is due to nitric oxide; however, a significant portion is also mediated by PGs.

Acetylcholine emails
Q. The description of Acetylcholine clearly states how it has been shown to improve brain function and sex drive...nothing about appetite reduction was included. Are you aware of any?
   A. Acetylcholine probably has some mild appetite suppressing activity.

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