Acromegaly and Gigantism by Ray Sahelian, M.D. Acromegaly symptom and treatment

The last decade has seen two major changes in the management of patients with growth hormone (HGH)-secreting pituitary tumors. Firstly, evidence has revealed a common pattern of increased mortality in patients with elevated GH and/or the target growth factor insulin-like growth factor-I (IGF-I). Secondly, the availability of highly specific and selective pharmacological agents to lower GH and/or IGF-I levels has greatly facilitated a more aggressive approach to the treatment of patients with persistently active acromegaly.

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Acromegaly symptom
Symptoms of acromegaly disease vary depending on how long the patient has had the disease. Common acromegaly symptoms include swelling of the hands and feet, facial features become coarse as bones grow, body hair becomes coarse as the skin thickens and/or darkens, increased perspiration accompanied with body odor, protruding jaw, enlarged lip, nose, and tongue, joint pain, enlarged heart, and other symptoms

Acromegaly and Gigantism
I
n both conditions of HGH excess, gigantism and acromegaly, the tongue enlarges, body hair becomes more coarse and the skin thickens. Due to enlargement of the sweat glands, more perspiration is produced and body odor could well become quite unpleasant.
   A very consequence of gigantism and acromegaly disease is heart enlargement. leading to heart failure. Nerves leading from the eyes to the brain may be compressed, causing loss of vision. Many patients with acromegaly and gigantism report severe headaches.

Acromegaly treatment
The purpose of acromegaly treatment is to reduce growth hormone production to normal levels. Additional reasons to treat this condition is to relieve the pressure that the growing pituitary tumor exerts on the surrounding brain areas, to preserve normal pituitary function, and to reverse or ameliorate the symptoms of acromegaly. Currently, treatment options include surgical removal of the tumor, drug therapy, and radiation therapy of the pituitary.

Acromegaly disease questions
Q. What would happen if someone with acromegaly disease took over the counter hormones DHEA or pregnenolone?
   A. This is an interesting question. I really don't know but my first impression is that it would have negative consequences.

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