Active Hexose Correlated Compound information, safety, side effects, review, supplement health benefit and use as a treatment for cancer and tumors
How well does it work? 500 mg per pill

September 1 2017

AHCC is a mushroom extract supplement that has been tested for its potential with the immune system, liver health and as a biological response modifier. Active Hexose-Correlated Compound was developed in Japan in 1989, and most of the studies with Active Hexose-Correlated Compound supplement have been conducted in Japan. Many people take this supplement as a treatment for certain cancers. The early research looks promising and hopefully future studies will give us a better understanding of which forms of cancer are best treated with this natural extract, its safety, and the proper dosage for long term treatment.

How is this supplement made?
This substance is an extract of mycelium, obtained through the long-term cultivation of several types of basidiomycetes medicinal mushrooms including Shiitake. After undergoing enzymatic decomposition, concentration, and freeze-drying, Active Hexose-Correlated Compound is obtained from the cultured liquid. Active components of Active Hexose-Correlated Compound include glucans and an oligosaccharide. Active Hexose-Correlated Compound is also a mixture of polysaccharides, amino acids, lipids and minerals
.

Buy Active Hexose-Correlated Compound supplement  500 mg, 60 Capsules

Active Hexose-Correlated Compound supplement (Active Hexose Correlated Compound) is a proprietary compound produced by cultivation and enzymatic modification of several species of mushroom mycelia, including shiitake, grown in rice bran extract. Considered a superfood supplement in Japan, Active Hexose-Correlated Compound has been researched extensively for its immune enhancement properties. According to human and animal research Active Hexose-Correlated Compound may increase natural killer cell activity. Active Hexose-Correlated Compound mfay also increase macrophage activity, enhance cytokine production, and support the healthy functioning of the liver as well as act as an antioxidant.


Supplement Facts:
Active Hexose-Correlated Compound Proprietary Blend 500 mg
    Mushroom Mycelia Extract, Candelilla Wax,
    Cyclodextrin, and Microcrystalline Cellulose.

Suggested Use: 1 or 2 Active Hexose-Correlated Compound capsules daily on an empty stomach, or as recommended by your health care professional.  For general well-being, take 1 Active Hexose-Correlated Compound capsules a few times a week. Consult your doctor if you plan to use AHCC for more than one or two months.
* Active Hexose-Correlated Compound supplement daily value not established.

Studies in mice show Active Hexose-Correlated Compound supplement
Enhances resistance to infection.
Enhances natural killer cell activity.
Protects the liver from injury induced by toxic or anti- cancer agents.
Active Hexose-Correlated Compound may have potential as an immune enhancing agent in the therapy of opportunistic infections.
Reduces breast cancer metastasis in mice when combined with chemotherapy agents.
May even have antioxidant properties.
Can help fight against certain viral infections.

Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice.
J Nutr. 2009. Wang S, Welte T, Fang H, Chang GJ, Born WK, O'Brien RL, Sun B, Kosuna K. Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
West Nile virus poses a serious threat to public health, especially to the elderly and the immuno-compromised. Neither vaccines nor treatments are available for humans. Active hexose correlated compound is an extract of Lentinula edodes of the Basidiomycete family of fungi rich in alpha-glucans. In this study, we evaluated the effect of Active hexose correlated compound on host susceptibility in the murine model of West Nile virus infection. AHCC administration in young (6- to 8-wk-old) mice attenuated viremia and mortality following lethal WNV infection. Active hexose correlated compound administration in aged mice attenuated viremia levels but led to no difference in mortality rate. Overall, our data suggests that Active hexose correlated compound enhances protective host immune responses against WNV infection in young and aged mice.

Supplementation with active hexose correlated compound Active Hexose-Correlated Compound increases the innate immune response of young mice to primary influenza infection.
J Nutrition. 2006. Department of Bioscience and Biotechnology, Drexel University, Philadelphia, PA,
The emergence of H5N1 avian influenza and the threat of new or adapted viruses in bioterrorism have created an urgent interest in identifying agents to enhance the immune response to primary virus infection. Active hexose correlated compound Active Hexose-Correlated Compound is a natural mushroom extract reported to increase natural killer (NK) cell activity, survival, and bacterial clearance in young mice. However, the effects of Active Hexose-Correlated Compound on the response to viral infections have not been studied. In this study, young C57BL/6 mice were supplemented with 1 g Active Hexose-Correlated Compound /(kg body weight x d) for 1 wk prior to and throughout infection with influenza A (H1N1, PR8). Supplementation increased survival, decreased the severity of infection, and shortened recovery time following intranasal infection with flu, as determined by the recovery of body weight and epithelial integrity in the lungs. Active Hexose-Correlated Compound increased NK activity in lungs at d 1 and d 4 and in the spleen at d 2 postinfection. Supplementation increased the percentage and number of NK1.1+ cells in the lung and reduced the infiltration of lymphocytes and macrophages compared with controls. Our data suggest that Active Hexose-Correlated Compound supplementation boosts NK activity, improves survival, and reduces the severity of influenza infection in young mice.


Studies in humans show Active Hexose-Correlated Compound supplement
Has protective effects on the liver in cases of liver injury, cirrhosis, cancer, or hepatitis.
Active Hexose-Correlated Compound and cancer -- one study shows Active Hexose-Correlated Compound improves the prognosis in patients with hepatocellular cancer however several more studies are needed before determining the role of Active Hexose-Correlated Compound in cancer treatment in humans.

Prognostic improvement of patients with advanced liver cancer after active hexose correlated compound Active Hexose-Correlated Compound treatment.
Asian Pac J Allergy Immunology 2006. Faculty of Allied Health Sciences, Thammasat University Rangsit Campus, Patumthani, Thailand.
Active Hexose-Correlated Compound was found to improve the prognosis of hepatocellular carcinoma patients following surgical treatment. We investigated whether Active Hexose-Correlated Compound could prolong survival and improve the prognosis of patients with advanced liver cancer. A prospective cohort study was performed with 44 patients with histologically confirmed liver cancer. All of the patients underwent supportive care. Of the 44 patients, 34 and 10 received Active Hexose-Correlated Compound and placebo orally, respectively. Patients in the Active Hexose-Correlated Compound treated-group had a significantly prolonged survival when compared to the control group. Quality of life in terms of mental stability, general physical health status, and ability to have normal activities were significantly improved after 3 months of Active Hexose-Correlated Compound treatment. Unlike the control patients, Active Hexose-Correlated Compound treated-patients with longer survival time had the tendency of better outcomes since the levels of AST and ALT had not increased rapidly from their baselines at follow-up. In addition, the levels of total IL-12 and neopterin were slightly increased in Active Hexose-Correlated Compound treated-patients. This study suggests that Active Hexose-Correlated Compound intake could prolong the survival and improve the prognosis of patients with advanced liver cancer and delay the gradual decline of their physiological status.

Dosage
Many of the studies in humans have used dosages of Active Hexose-Correlated Compound supplement of about 3 grams a day. The ideal dosage Active Hexose-Correlated Compound in cancer or other conditions for long term use is still being evaluated.

Safety, risks, danger, side effects
No major health risks have been reported in the medical literature as of 2017.

Summary and review 
More research is needed before making any firm recommendations on effectiveness, dosage, frequency and length of use, interactions with radiotherapy and chemotherapy, and the conditions for which this interesting compound can be useful. Thus far much of the Active Hexose-Correlated Compound and cancer research looks promising but few are have been done in humans.

Active Hexose-Correlated Compound for a dog
I have a Malamute who is around 10 years old with liver cancer. I would like to know if
Active Hexose-Correlated Compound product can be given to my dog for her liver cancer. I would appreciate any information you can give me regarding this matter. If this is okay to give to my dog I am willing to purchase Active Hexose-Correlated Compound to help her get better.
    We have not seen studies regarding the role of
Active Hexose-Correlated Compound as a treatment for liver cancer in a dog and don't have an idea whether it would help.

Active Hexose-Correlated Compound Research study
Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses.
Cancer Immunol Immunother. 2006. Gao Y, Zhang D, et al. Section of Rheumatology, Department of Medicine, Yale School of Medicine, CAB Building, New Haven, CT
Active Hexose-Correlated Compound has been studied for its role in immune functions. In this study, C57BL/6 mice were orally administered Active Hexose-Correlated Compound or water, followed by tumor cell inoculation. Compared to pure water-treated mice, Active Hexose-Correlated Compound treatment significantly delayed tumor development after inoculation of either melanoma cell line B16F0 or lymphoma cell line EL4.

Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses.
Cancer Immunol Immunother. 2005
Section of Rheumatology, Department of Medicine, Yale School of Medicine, CAB Building, New Haven, CT
In this study, C57BL/6 mice were orally administered Active Hexose-Correlated Compound or water, followed by tumor cell inoculation. We showed that compared to pure water-treated mice, Active Hexose-Correlated Compound treatment significantly delayed tumor development after inoculation of either melanoma cell line B16F0 or lymphoma cell line EL4. Treatment with Active Hexose-Correlated Compound enhanced both Ag-specific activation and proliferation of CD4(+) and CD8(+) T cells, increased the number of tumor Ag-specific CD8(+) T cells, and more importantly, increased the frequency of tumor Ag-specific IFN-gamma producing CD8(+) T cells. Interestingly, Active Hexose-Correlated Compound treatment also showed increased cell number of NK and gammadelta T cells, indicating the role of AHCC in activating these innate-like lymphocytes. In summary, our results demonstrate that Active Hexose-Correlated Compound can enhance tumor immune surveillance through regulating both innate and adaptive immune responses.

Active Hexose-Correlated Compound Enhances the Immune Function of Mice in the Hindlimb-Unloading Model of Space Flight Conditions.
Department of Microbiology, Morehouse School of Medicine, Atlanta
J Applied Physiology. 2004
Hindlimb-unloading is a ground-based model that simulates some of the aspects of space flight conditions including lack of load bearing on hindlimbs and a fluid shift to the head. It has been shown that treatment with Active Hexose Correlated Compound ( Active Hexose-Correlated Compound ) restores resistance to infection in mice maintained under hindlimb-unloading conditions. The present study was designed to clarify the mechanisms by which Active Hexose-Correlated Compound enhances resistance to infection in this model. We hypothesized that oral administration of Active Hexose-Correlated Compound will enhance the function of the immune system, which could lead to the increased resistance to infection observed in this model. Active Hexose-Correlated Compound or the excipient was orally administered to mice and the function of the immune system was assessed in spleen and peritoneal cells isolated from those groups. The results of the current study showed that, administration of Active Hexose-Correlated Compound for one week prior to and throughout the 2nd day of hindlimb-unloading period enhanced the function of the immune system assessed by spleen cell proliferation and cytokine production in spleens and nitric oxide and cytokine production in peritoneal cells. These findings suggest that Active Hexose-Correlated Compound can be used as a potent immunoenhancer especially in cases where the immune system is suppressed by any condition including diseases such as HIV infection and cancer.

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Supplement inquiries
Q. I have seen various forms of Active Hexose-Correlated Compound, Immpower and Kinoko Active Hexose-Correlated Compound. Which form of Active Hexose-Correlated Compound is best?
   A. There are several Active Hexose-Correlated Compound products available, including ImmPower made by American Biosciences. According to the manufacturer, ImmPower is Active Hexose Correlated Compound, developed by combining several species of mushrooms used in traditional Japanese healing to make one, extremely powerful, hybridized mushroom. This hybridized mushroom is grown in a liquid medium containing rice bran and enzymatically modified to be readily absorbable.  Kinoko Active Hexose-Correlated Compound is made by Quality of Life Labs. Several other companies private label Active Hexose-Correlated Compound including Source Naturals and NOW Foods.

Which is more potent, AHCC extract or cordyceps extract in terms of its effect on the immune system?
    They work in different ways, so it is not easy to give a simple answer.