Adipocyte by Ray Sahelian, M.D.
An adipocyte is basically a fat cell, a cell that has become specialized in the making and storage of fat.
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Research Update newsletter. Once or twice a month we email a brief
abstract of several studies on various supplements and natural medicine
topics, and
their practical interpretation by Ray Sahelian, M.D. We will discuss adipocyte
research.
Function of adipocyte
The adipocyte is important to the body in maintaining proper energy balance,
storing calories in the form of lipids, and mobilizing energy sources in
response to hormonal stimulation. Interest in the biology of white adipose tissue has
risen markedly with the recent surge in obesity and its associated disorders. Adipocytes are no longer viewed simply as a vehicle for lipid storage; instead,
the adipocyte is recognized as a major endocrine and secretory cell and
adipocytes, collectively, act as an organ.
Adipocytes as Endocrine Organs
White adipocytes
release a number of protein hormones, signals and factors, termed adipokines, with an extensive range of physiological actions. Foremost among
these various adipokines is the cytokine-like hormone, leptin, which is
synthesized predominantly in white fat. White fat also secretes several putative appetite-related adipokines, which
include interleukin-6 and adiponectin, but whether these are indeed significant
signals in the regulation of food intake has not been established. Through
leptin and the other adipokines it is evident that adipose tissue communicates
extensively with other organs and plays a pervasive role in metabolic
homeostasis.
Adipocyte and toxins
White
adipose tissue represents
a reservoir of lipophilic environmental pollutants, especially of those which
are resistant to biological and chemical degradation - so called persistent
organic pollutants.