Agastache rugosa plant medical uses and treatment
April 14 2016

Agastache rugosa is called by several common names including Korean Mint, Purple Giant Hyssop, Huo xiang, and Wrinkled Giant Hyssop. This plant is used often by Chinese herbalists.

Human studies - None could be found as of 2016

Benefit of agastache rugosa herb
The agastache rugosa plant is promoted as having antifungal and anti-cancer properties.

Antifungal activity
Estragole is an essential oil from Agastache rugosa that has antifungal activity.

Antioxidant activity
Protein kinase G-dependent heme oxygenase-1 induction by Agastache rugosa leaf extract protects RAW264.7 cells from hydrogen peroxide-induced injury.
J Ethnopharmacol. 2006; Department of Pharmacology, School of Medicine, Institute of Health Sciences, Gyeongsang National University, South Korea.
It has been proposed that the inducible isoform of heme oxygenase (HO) protects cells against oxidant-mediated injury. Although components of Agastache rugosa showed antioxidant effect, it is unclear this effect is related with HO-1 activity. Thus, we investigated the effects of Agastache rugosa leaf extract on HO-1 protein expression and enzyme activity, and its protective effect against H(2)O(2)-induced oxidative damage was also investigated using RAW264.7 macrophage cells.  Our results show this herb may be beneficial for the treatment of oxidant-induced cellular injuries.

Root composition
Roots of Agastache rugosa have maslinic acid, oleanolic acid, rosmarinic acid, 3-O-acetyl oleanolic aldehyde, acacetin, tilianin, agastachoside, daucosterol, beta-sitosterol, and dehydroagastol. Agastaquinone is a diterpenoid quinone found in the root of this plant.

Essential oils in Agastache rugosa
These include estragole, methylchavicol, d-limonene, caryophyllene, and hexadecanoic acid.

Lignans in Agastache rugosa
Agastinol and agastenol are lignans found in agastache rugosa.

Toxicity
BMC Complement Altern Med. 2014 Dec 15. Analysis of the volatile organic compounds from leaves, flower spikes, and nectar of Australian grown Agastache rugosa. The foraging choices of honey bees are influenced by many factors, such as floral aroma. The composition of volatile compounds influences the bioactivity of the aromatic plants and honey produced from them. In this study, Agastache rugosa was evaluated as part of a project to select the most promising medicinal plant species for production of bioactive honey. Headspace solid-phase microextraction HS-SPME /GC-MS was optimized to identify the volatile bioactive compounds in the leaves, flower spikes, and for the first time, the flower nectar of Australian grown A. rugosa. Methyl chavicol (= estragole) was the predominant headspace volatile compound in the flowers with nectar, flower spikes, and leaves, with a total of 97.16%, 96.74% and 94.35%, respectively. Current results indicate that HS-SPME/GC-MS could be a useful tool for screening estragole concentration in herbal products. :Recently, estragole was suspected to be carcinogenic and genotoxic, according to the European Union Committee on Herbal Medicinal Products. Further studies are needed on safe daily intake of Agastache as herbal tea or honey, as well as for topical uses.

Animal studies
Agastache rugosa has an anti-atherogenic effect in low density lipoprotein receptors in mice.

In vitro studies
Agastache rugosa leaf extract inhibits the iNOS expression in ROS 17/2.8 cells activated with TNF-alpha and IL-1beta.
Arch Pharm Res. 2005. Department of Pharmacology, College of Medicine, and Institute of Health Sciences, Gyeongsang National University, Jinju, Korea.

Products
Q. I came across a product called Nohang that has Agastache rugosa. Does it work for alcohol hangover problems? On the Nohang label they call Agastache rugosa beefsteak plant.
   A. We are not aware of any research regarding the use of Agastache rugosa herb as a treatment for alcohol hangover issues. You may consider another product called asparagus extract which could be of benefit for the prevention or treatment of alcohol induced hangover.

Interactions
Can this herb be taken in combination with ahcc mushroom extract for immune system support?
    We have not seen such studies using this combination.