Allicin is a highly active component from freshly crushed garlic, is produced upon the reaction of the small molecular weight molecule alliin, with the enzyme alliinase.
Garlic and Parsley
Source Naturals

Garlic and its key constituents have been the subject of hundreds of scientific
studies. Garlic has been used around the world for thousands of years for its
nutritional value. Parsley is favorite herb for salads, and cooking. It also is
refreshing and soothing and contains assimilated essential minerals.
This product contains true oils of garlic and parsley
seed, extracted from whole fresh garlic bulb and parsley seed, and suspended in
pure soy bean oil. It is a convenient way to receive the benefits of garlic and
parsley seed in concentrated form, without the taste and odor, along with
antioxidant
benefits.
See garlic
to purchase.
Supplement Facts
Garlic Oil 5 mg (equivalent to 500 mg of fresh garlic)
Parsley Seed Oil
Allicin side effects, safety
Allicin is safe with hardly any side effects except in high dosages it may thin
the blood and those taking Coumadin or blood thinners should be cautious. There
is a possibility of allergic reactions to this
herb in rare cases.
Allicin Research
Allicin and allicin -derived garlic compounds increase breath acetone
through allyl methyl sulfide: use in measuring allicin bioavailability.
J Agric Food Chem. 2005.
Progress in establishing systemic pharmacological effects for fresh, crushed
garlic (Allium sativum) in humans has been hindered by (1) the inability to
measure allicin bioavailability, (2) lack of direct evidence that allicin has
significant systemic activity at doses of garlic normally consumed, and (3) lack
of a model for an acute effect. We have addressed these problems by quantifying
the increases in breath acetone and breath allyl methyl sulfide (AMS). The area
under the 48 h curve was measured in humans after consumption of standardized
garlic preparations, allicin, and allicin-derived compounds, at the equivalent
of 7 g of crushed garlic. It was shown that the allyl thiosulfinates (mainly
allicin) are solely responsible for breath AMS and increased breath acetone.
Diallyl trisulfide, diallyl disulfide, ajoene, and S-allylmercaptocysteine, at
isomolar dithioallyl, showed the same quantitative effects. MS is the main
active metabolite of allicin. In conclusion, allicin and allicin -derived compounds are rapidly
metabolized to AMS, a compound which stimulates the production of acetone and
which can be used to measure the bioavailability of allicin and, hence, the
ability of garlic supplements to represent fresh garlic.
An overview of the antifungal properties of allicin and its breakdown
products--the possibility of a safe and effective antifungal prophylactic.
Mycoses. 2005.
Some
of the breakdown products of allicin, the main parent antifungal compound in
garlic, have been investigated for their general antimicrobial, anticancer and
anticholesterol properties, and it appears that there is a common mode of action
that underlies these activities. It appears that these small molecules have the
ability to cross cell membranes and combine with sulfur-containing molecular
groups in amino acids and proteins, thus interfering with cell metabolism. It
has been suggested that the reason human cells are not poisoned by allicin
derivatives is that they contain glutathione, a sulfur-containing amino acid
that combines with the allicin derivative, thus preventing cell damage. In
addition to their biochemical mechanism, these derivatives appear to stimulate
cellular immunity, an important ability lacking in conventional antifungal
chemotherapy. These derivatives appear to be safe, cheap, wide-spectrum and
immunostimulatory, as well as possibly synergistic with conventional antifungal
therapy, making them ideal candidates for investigation into their use as
prophylactic antifungal agents.
Allicin induced cell cycle arrest in human gastric
cancer cell lines
Zhonghua Zhong Liu Za Zhi. 2004.
The gastric cancer cell lines MGC-803 and SGC-7901 were treated with allicin
which induced cell arrest of gastric cancer in M phase.
questions
Q. A few years ago, studies showed allicin-containing vegetables to be very
effective in reducing the incidence of prostate cancer. Several such vegetables
were found effective, but scallions were by far the best in this respect.
Scallions are relatively rare, but green onions are generally considered to be
their equivalent, at least in cooking.
Green onions are available chopped, dried and sold in packages. Typically, the
suppliers have no information concerning the allicin content, if any, of this
product. Do you think these dehydrated green onions might
contain enough allicin to be useful for health purposes?
A. There could be wide variations in the allicin content of
different products depending on how they are manufactured and processed. As a
rule, the allicin content in dehydrated herbs would be much less than in raw
herb. I prefer consuming raw scallion or garlic.
Any side effects from high doses of stabilised Allicin
180 mg in particular! I havent notice any yet and I pop 380 mg of it per day to
treat a stuborn infection along with boosting my Immune system. They have been
able to stablelise it and are treating MRSA patients in England with it
successfuly! I think.
I have not come across any significant side effects with this
product reported in medical journals as of 2009.