Aniracetam smart drug
May 16 2016 by Ray Sahelian, M.D.
Aniracetam is a nootropic compound and an allosteric modulator of AMPA receptors (AMPARs) which mediate synaptic mechanisms of learning and memory.
Aniracetam use by the elderly
Pharmacokinetic study of aniracetam in elderly patients with cerebrovascular disease.
Behav Brain Res. 1997. Department of Geriatrics, National Chubu Hospital, Ohbu, Japan.
The clinical pharmacokinetics of the cognitive enhancer, aniracetam (200 mg), was studied in elderly patients with cerebrovascular disease and compared with those of young healthy volunteers. Six female hospitalized patients (mean age 84.5 years) were used in this study. The serum level of anisic acid and p-methoxyhippuric acid, major metabolites of aniracetam, reached a peak at 2 h after oral administration, and returned to basal level by 6 h. Mean creatinine clearance was 20-30 ml/min. The t1/2 of metabolites was increased by 4- to 7-fold in the elderly patients compared with young volunteers. This study showed that tmax and AUC were enlarged in the elderly; however, no clinical side effects were observed.
Additional nootropic drugs
Oxiracetam nootropic medication
Piracetam nootropic medication
Zhongguo Zhong Yao Za Zhi. 2014. Real-world analysis of
concurrent diseases and medicine use among patients with insomnia]. This study
aims to explore and analyze the condition of concurrent diseases and medicine
use of traditional Chinese medicine (TCM) and western medicine among the
patients with insomnia. One thousand and sxity seven cases of data from 20
national hospitals' hospital information system (HIS) databases were collected.
The frequent concurrent diseases included hypertension (26.9%), brain blood
supply insufficiency (24.93%), cerebral infarction (19.49%), blood lipoprotein
disturbance (15.28%), coronary heart disease (14.15%), headache (10.68%),
chronic gastritis (8.81%), type 2 diabetes mellitus (7.87%), depressive disorder
(7.4%) and anxiety disorder (6.65%). The 10 most frequently-used western drugs
included alprazolam (35.99%), aspirin (25.4%), olanzapine (24.18%), cinepazide
(23.06%), flupentixol & melitracen (18.74%), zolpidem, oxiracetam (15.65%),
estazolam (15%), aniracetam (13.4%) and piracetam (13.31%). The 10 most
frequently-used TCM included Shuxuening injection (16.4%), Shuxuetong injection
(15.18%), extract of ginkgo biloba leaf (14.71%), gastrodin (12.46%),
Dengzanxixin injection (11.34%), Xueshuantong (8.53%), Danhong injection
(6.37%), compound liquorice tablet (5.81%), Sanqi Tongshu capsule (5.72%) and
sowthistle-leaf ixeridium injection (5.34%). Among all combined uses, the most
frequent western drug use was alprazolam and olanzapine, while combined use of
hypnotic drug and Huoxuehuayu formula is the most frequent.