Aniracetam by Ray Sahelian, M.D.
Aniracetam is a nootropic compound and an allosteric modulator of AMPA receptors (AMPARs) which mediate synaptic mechanisms of learning and memory.
Aniracetam use by the elderly
Pharmacokinetic study of aniracetam in elderly patients with cerebrovascular
disease.
Behav Brain Res. 1997 Feb;83(1-2):243-4. Department of Geriatrics, National
Chubu Hospital, Ohbu, Japan.
The clinical pharmacokinetics of the cognitive enhancer, aniracetam (200 mg),
was studied in elderly patients with cerebrovascular disease (CVD) and compared
with those of young healthy volunteers. Six female hospitalized patients (mean
age 84.5 years) were used in this study. The serum level of anisic acid and p-methoxyhippuric
acid, major metabolites of aniracetam, reached a peak at 2 h after oral
administration, and returned to basal level by 6 h. Mean creatinine clearance
was 20-30 ml/min. The t1/2 of metabolites was increased by 4- to 7-fold in the
elderly patients compared with young volunteers. This study showed that tmax,
t1/2, and AUC were enlarged in the elderly; however, no clinical side effects
were observed.
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