Arjunolic acid from Terminalia Arjuna herb
February 1 2017

Arjunolic acid is a naturally occurring chiral triterpenoid saponin and has potential use as an antioxidant, anti-fungal, anti-bacterial, anticholinesterase, antitumor, and for asthma. The scientific basis behind its therapeutic application as a cardioprotective agent in traditional medicine is justified by its ability to prevent myocardial necrosis and apoptosis, platelet aggregation, coagulation and lowering of blood pressure, heart rate, as well as cholesterol levels. Its antioxidant property coupled with metal chelating property (by its two hydroxyl groups) protects different organs from metal and drug-induced organ damage. Arjunolic acid also plays a beneficial role in the pathogenesis of diabetes and its associated complications.

Review
Biochimie. 2013. Arjunolic acid: a new multifunctional therapeutic promise of alternative medicine. The multifunctional therapeutic application of arjunolic acid has already been documented by its various biological functions including antioxidant, anti-fungal, anti-bacterial, anticholinesterase, antitumor, antiasthmatic, wound healing and insect growth inhibitor activities. The scientific basis behind its therapeutic application as a cardioprotective agent in traditional medicine is justified by its ability to prevent myocardial necrosis and apoptosis, platelet aggregation, coagulation and lowering of blood pressure, heart rate, as well as cholesterol levels. Its antioxidant property coupled with metal chelating property (by its two hydroxyl groups) protects different organs from metal and drug-induced organ pathophysiology. Arjunolic acid also plays a beneficial role in the pathogenesis of diabetes and its associated complications. The mechanism of cytoprotection of arjunolic acid, at least in part, results from the detoxification of reactive oxygen species (ROS) produced in the respective pathophysiology. In addition to its other biological functions, it also possesses vibrant insecticidal properties and it has the potential to be used as a structural molecular framework for the design of molecular receptors in the general area of supramolecular chemistry and nanochemistry. Esters of arjunolic acid function as organogelators which has wide application in designing thermochromic switches and sensor devices. Arjunolic acid derived crown ether is an attractive candidate for the design of molecular receptors, biomimetics and supramolecular systems capable of performing some biological functions.

Blood sugar, diabetes
Streptozotocin induced activation of oxidative stress responsive splenic cell signaling pathways: Protective role of arjunolic acid.
Toxicol Appl Pharmacol. 2010. Manna P, Ghosh J, Das J. Division of Molecular Medicine, Bose Institute, CIT Scheme VIIM, Calcutta, West Bengal, India.
Present study investigates the beneficial role of arjunolic acid against the alteration in the cytokine levels and simultaneous activation of oxidative stress responsive signaling pathways in spleen under hyperglycemic condition. Diabetes was induced by injection of streptozotocin (STZ). Histological examination revealed that diabetic induction depleted the white pulp scoring which is in agreement with the reduced immunological response. Treatment with arjunolic acid prevented the hyperglycemia and its associated pathogenesis in spleen tissue. Results suggest that arjunolic acid might act as an anti-diabetic and immunomodulatory agent against hyperglycemia.

Self-Assembly of Esters of Arjunolic Acid into Fibrous Networks and the Properties of their Organogels (dagger).
Langmuir. 2009. Bag BG, Dinda SK. Department of Chemistry and Chemical Technology, Vidyasagar University, Midnapore, WB, India.
Nine esters of a naturally occurring triterpenoid, arjunolic acid, with alkyl chains have been synthesized, and their self-assembly has been studied in organic liquids. All of the esters examined were found to be excellent gelators. No birefringence was detected in optical micrographs of the transparent toluene gels with 5% ethyl arjunolate or 5% p-nitrobenzyl arjunolate as the gelator, but a spherulitic-type pattern was seen for a gel of p-nitrobenzyl arjunolate in chloroform/cyclohexane. Electron microscope images revealed self-assembled fibrillar network (SAFIN) structures with right-handed helical ribbons in some gels.