Avandia danger, safety, risks,
premature death side effects
and adverse events
- for diabetes treatment, may shorten lifespan
June 1 2016 by Ray Sahelian, M.D.
Avandia is an oral diabetes medicine that helps control blood sugar levels. This prescription medication helps your body respond better to insulin produced by your pancreas. Avandia is prescribed for people with type 2 diabetes who do not use daily insulin injections. For natural options to treating diabetes with diet and supplements. Blood sugar can be decreased by eating less.
Safety warnings, health danger
BMC Health Serv Res. 2014. Utilisation trends of rosiglitazone and pioglitazone in Australia before and after safety warnings. The changes to the patterns of rosiglitazone and pioglitazone utilisation in Australia following the timing of these various health authority warnings such as the Australian Therapeutic Good Administration (TGA), European Medicines Agency (EMA) press releases or U.S. Food and Drug Administration (FDA) is unknown. This study investigated the utilisation patterns of rosiglitazone and pioglitazone in Australia before and after warnings of major drug authorities. Drug safety warnings were associated with a decrease in rosiglitazone and pioglitazone utilisation in Australia. Rosiglitazone began to decline prior to TGA warnings in December 2007, which suggests that Australian prescribers may have acted in response to scientific evidence or international safety warnings (EMA, FDA), prior to the response of the TGA.
2010 - European health regulators have banned sales because of evidence it raises the risk of heart attack, but doctors in the U.S. will be able to continue prescribing it with some significant restrictions. In simultaneous news briefings, the European Medicines Agency and the U.S. Food and Drug Administration announced their decisions on the controversial diabetes medication. The European regulator said it would stop authorizing marketing of Avandia and said it would be removed from the market within the next few months. Earlier this month, Britain's drug regulator said an independent panel of experts concluded it raised the risk of heart attacks and recommended it be pulled from the market. FDA announced that new patients will be able to get a prescription for Avandia only if they can't control their blood sugar with other medications. Doctors will have to document that their patients are eligible to receive the drug and have been briefed on its risks. FDA expects the restriction plan "will limit its usesignificantly.
2010 - GlaxoSmithKline Plc has agreed a first round of settlements for some 700 cases brought by patients alleging its Avandia diabetes drug caused heart attacks. Glaxo will pay about $60 million to resolve the suits filed by three attorneys - a relatively small amount compared with the total liabilities some investors fear it could face.
2010 - Nearly all of the experts who wrote favorably about troubled diabetes drug Avandia had financial ties to drug makers. A team at the Mayo Clinic in Rochester, Minnesota, combed through more than 200 scientific studies and commentaries that offered positive opinions about Avandia after a May 2007 study suggested the drug significantly increased the risk of heart attacks. They found that 94 percent of the authors who defended the drug -- known generically as rosiglitazone and made by GlaxoSmithKline Plc's -- had ties to drug companies, and nearly half had financial ties that presented a conflict of interest.
2010 - A Senate report said that drug maker GlaxoSmithKline knew of possible heart attack risks tied to Avandia, its diabetes medication, years before such evidence became public.Sen. Max Baucus, chairman of the Senate Finance Committee, and Chuck Grassley, the committee's ranking Republican, released the report, which follows a two-year inquiry.
Avandia Danger: 2007 - Dr. Bernd Richter of Heinrich-Heine University in Duesseldorg, Germany, and his staff, found little evidence that Avandia, a thiazolidinedione, improves the quality or length of life. Avandia actually worsens complications of diabetes. He now questions whether it is ethical to conduct any further clinical tests with Avandia, since safer alternative treatments are available.
2007 - A senior Food and Drug Administration scientist informed US Senate investigators that the FDA removed him from work on GlaxoSmithKline Plc's drug Avandia after he voiced concerns about the safety of Avandia. The unnamed FDA medical officer at one time was the primary reviewer for Avandia. The reviewer has believed since 2005 that there was enough evidence for a strong "black box" warning on Avandia about the risk of heart problems.
Avandia and heart attack
This widely prescribed diabetes drug is linked to a greater risk of heart attack and possibly death. More than 6 million people worldwide have taken the drug since it came on the market in 1999. Pooled results of dozens of studies revealed a much higher risk of heart attack. This was published in the May 2007 issue of the New England Journal of Medicine.
Patients taking either of the diabetes drugs Avandia or Actos face twice the risk of developing heart failure compared to people not on the popular medications.
Avandia and bone fractures
There is an increased incidence of fractures of the upper arm, hand, or foot in women with type 2 diabetes mellitus on Avandia. Avandia stimulates the action of a cell that drives the normal bodily process of reabsorbing bone, making bones more likely to break.
The long-term use of two diabetes drugs, Avandia (GlaxoSmithKline) and Actos (Takeda) significantly increases the risk of bone fractures in women with type 2 diabetes.
Side effects of Avandia, risk, danger, adverse reactions
Avandia can cause an allergic reaction. Allergic side effects include hives; difficulty breathing; swelling of the face, lips, tongue, or throat. Additional Avandia serous side effects include signs of congestive heart failure (swelling or rapid weight gain, shortness of breath, chest pain). Gastrointestinal Avandia side effects include nausea, vomiting, stomach pain, or loss of appetite, and jaundice. other Avandia side effects could include fatigue, hypoglycemia, headache, weakness, sweating, and rapid heart beat.
Avandia side effect - bone loss
Patients taking GlaxoSmithKline Plc diabetes drug Avandia may have an additional side effect - a higher risk of hip and other fractures because the medicine decreases bone formation. A study of 50 postmenopausal women found those on Avandia, generic name rosiglitazone, had a 1.9 percent fall in total hip bone density after 14 weeks of treatment, while those on a placebo experienced a reduction of 0.2 percent. Lumbar spine bone density also fell significantly compared with starting levels but not compared with the placebo. The small New Zealand study comes on the heels of a major clinical trial of Avandia, called ADOPT, reported in December, 2006 which found an unexpected rise in peripheral fractures, most commonly involving the foot and upper limbs. An osteoporosis warning will be added to the drug's label, providing additional ammunition for Merck & Co Inc and Novartis AG as they roll out a new class of diabetes pills known as DPP-IV inhibitors. Merck has Januvia while Galvus is made by Novartis. Avandia is Glaxo's second-biggest seller, with sales of $2.5 billion in 2005.
Does Avandia reduce diabetes
Treatment of high-risk patients with the oral antidiabetic drug Avandia may reduce their risk of developing type 2 diabetes by nearly two thirds. In a clinical trial of patients with poor glucose tolerance, 5,269 adults were assigned to receive Avandia or a placebo (sugar pill) daily for an average of 3 years. At follow-up, the subjects in the Avandia group were less likely to develop the disease or die than those in the placebo group, and their risk of progressing to full diabetes was reduced by 60 percent. The Avandia patients were also 70-percent more likely to return to normal blood sugar levels. These patients did, however, have an increased risk of non-fatal heart failure, a condition where the heart muscle is weakened and becomes unable to maintain adequate blood supply to the body's tissues. The researchers, based at McMaster University, Hamilton, Ontario, Canada concluded that for every 1,000 people treated with Avandia for 3 years, about 144 cases of diabetes would be prevented and an extra 4 to 5 cases of heart failure would occur. The Canadian study also looked at the value of a blood pressure drug called ramipril, but found it did not reduce the risk of diabetes or death, although it did help some patients to return to normal blood sugar levels. Ramipril is sold as Altace by King Pharmaceuticals Inc. The study DREAM study (Diabetes REduction Assessment with ramipril and rosiglitazone Medication) was funded by the Canadian Institutes of Health Research, Sanofi-Aventis, GlaxoSmithKline and King Pharmaceuticals. The Lancet, September 15, 2006.
Before I prescribe Avandia to prevent diabetes, I would like to see a minimum of a seven year study to determine if Avandia has side effects that we are currently not aware of. It is possible that it could reduce the risk of diabetes, but the cardiac side effects could lead to people on this drug to die sooner. And now we find out that Avandia has side effects involving bone loss and potential osteoporosis.
Q. I write to you this day,
first thanking you for your work and in your mission to bring greater and
greater awareness of the natural means by which we can all improve our health
dramatically. I would like to relate to you my own experience with Avandia. I
was administered this medication as part of the protocol regimen in a hospital
in Northern California. This occurred in February of 2004. I previously had
congestive heart failure, and this is one of the main warnings in the Clinical
Trials for this medication, by which it's explained that there is a definite
danger in taking this medication while having previously experienced this
condition (CHF). Almost immediately, I began to experience edema of the feet,
and till this day, three years later, I still have not fully recovered from the
extreme swelling. By the end of the two year period after being administered
this medication, which was taken in conjunction with Metformin, and Glipizide; I
began to experience extreme problems breathing. I began my journey in several
visits to hospitals mainly suffering with double pneumonia and other bronchial
infections that would show up when not in the hospital with pneumonia. By
February of 2006, I was at the point where my room air saturation was down to
67%. And my breathing had deteriorated to such an extent that I had to use
supplemental oxygen 24/7 at three liter flow. Even at three liter flow, I was
still losing oxygen, and my lungs were not able to take a full breath, let alone
allow me the capacity to function in any way. Fortunately, I was sent an email
to look into oil swishing with Sunflower Oil. And within two weeks of using this
detox method, I was able to remove my oxygen completely. And I have remained
with full lung capacity since then. My Pulmonoligist has informed me two months
earlier that there was no going back from using the oxygen for the rest of my
life. He stated that my lungs had been damaged so much that it was impossible
for me to recover. When I visited him two months later, I walked in without my
oxygen tank, presented the clinical trials for Avandia, the testimonies of all
those others whom I found that had similar events such as mine due to the use of
Avandia. And finally, I showed him the information on the oil swishing. He was
so amazed that he immediately went to his other partner doctors in his office
and related to them what had happened to the ONLY patient of his that had ever
recovered from the severely damaged lungs that were in my medical report. He has
since begun to prescribe this method to his other patients. I really commend him
for that. Since this process of detox took place in my life, I began to look
into other natural means to treat my ailments of diabetes, high blood pressure,
hyper tension, etc. -- Needless to say, several of the products on your website
have been crucial, and I'm mighty grateful, as I'm so elated to be able to take
effective treatments for my condition and have no side effects. I've also
managed to lose quite a bit of weight as I had been morbidly obese for several
years, and now that I'm able to walk for the first time in over three years, so
much the better for my health. Thank you again for your time and effort in our
health, this is so much appreciated.
As far as the oil swishing is concerned, I used the Sunflower Oil (cold pressed). Using it daily in the morning before breakfast, I would take a tablespoon in my mouth and I would swish for at least 15 minutes. Later, I was able to swish for 30 minutes. The outcome was quite dramatic. From the very beginning I had extremely loose teeth, probably from the medication, as I had always had great teeth. At this time, they were about ready to fall out, as there was extreme bleeding, and the gum lines had grown well past the middle of my teeth. From the first use of the oil, the teeth began to react and on the second day the bleeding had stopped and the teeth had tightened in my mouth. The natural supplements that I used aside from being inexpensive, were honey and cinnamon as a tea every morning 30 minutes before breakfast. Also apple cider vinegar and honey as a drink with meals, and hydrogen peroxide therapy both orally and externally. I've used MultiVit Rx and Zyflamend. With excellent results. I've not been able to use others as of yet due to finances. But I really have appreciated the effect of the products that I have used. I thank you once again for this line of products and the wonderful benefit and alternative to conventional (deadly) medicine.
Q. I have diabetes type 2, I read and hear
constantly about how patients with diabetes need to keep their weight down, and
avoiding gaining weight around the waist (being pear-shaped). What I never see
or hear anything about is what to do when that weight gain is caused by the
diabetes medicines being taken. My doctor has stated the obvious - that I should
not stop taking the meds in order to lose the weight! I'm 57 years old. In my
case, three years ago, I put on 80 lbs over the course of a year, while
maintaining my exercise and diet regimen. My doctor started me on Avandia when
diet and exercise alone no longer maintained my blood sugar at the proper
levels. Over the next year, the Avandia dosage was doubled, then doubled again.
After it became apparent that it wasn't having the desired effect, Amaryl was
added, Avandia was later dropped,
A. Doctors agree that weight gain makes blood sugar control worse and leads to a worse case of diabetes. Eating less should, in general, keep blood sugar lower in those with type 2 diabetes. Weight loss should lower blood sugar in those who have diabetes. Diet Rx can help with appetite control and you can ask your doctor if it appropriate for you.