B Complex supplement health benefit, review of studies, dosage and side effects by Ray Sahelian, M.D.
How much of a
vitamin B complex do you need? Nobody really knows the answer to this, but my
personal opinion is that for the majority of people, there is no need to take
more than one, two, or three times the RDA on a long
term basis, although higher amounts can be taken on a short term basis.

For
an excellent daily multivitamin with
vitamin B complex, consider MultiVit Rx, a supplement that I formulated, a daily comprehensive multivitamin for more energy and vitality.
Vitamin B coenzyme complex supplements are the cheapest, safest, and most reliable way to improve your wellbeing and overall mental abilities. I recommend a Vitamin B complex to those who wish to improve their mood, mental clarity, and energy. The effects are subtle, especially in the young who normally have adequate dietary intake of these nutrients. Improvements in cognitive functions from vitamin B are particularly noticeable in middle age individuals and the elderly.
Most Vitamin B
Complex supplements have the following:
B 1 -- Thiamine Cocarboxylase
B 2 -- Riboflavin Flavin Mono Nucleotide
B 3 --
Niacin, Nicotinamide and
NADH
B 5 -- Pantothenic acid,
Pantethine
B 6 -- Pyridoxine Pyridoxal Phosphate
B12 -- Cyanocobalamin Dibencozide or Methylcobalamin
Folic acid
Biotin
Oral or sublingual B complex, there seems to be no
difference in overall benefit
It is important to take a B complex sublingually or is an oral pill good enough?
A single-center, double-blinded, randomized controlled study to evaluate the
relative efficacy of sublingual and oral vitamin B-complex administration in
reducing total serum homocysteine levels.
J Altern Complement Med. 2006. Yazaki Y, Mattie M.
College of Naturopathic Medicine, University of Bridgeport, Bridgeport, CT.
This study is designed to evaluate the relative efficacy of
sublingual versus orally delivered vitamin B complex in reducing serum homocysteine levels. Forty-one subjects, between the ages of 50 and 80
years with total serum homocysteine concentrations exceeding 11 micromol/L, were
treated with a six-week regimen of vitamin B complex. Each B complex consisted
of 1000 microg vitamin B12 (as methylcobalamin), 400 microgram folate (as folic
acid), and 5 mg vitamin B6 (as pyridoxine HCl). Participants in the study were
randomized into two groups designated, retrospectively, as sublingual and PO.
Members of group sublingual were given a sublingually delivered vitamin B
complex and a matching orally delivered placebo. Members of group PO were given
an orally delivered vitamin complex and a matching sublingually delivered
placebo. A significant reduction in homocysteine values was
observed in both groups upon completion of the 6-week protocol. There
was no significant difference in serum homocysteine concentrations
between sublingual vitamin B and oral vitamin B groups either before or after
treatment.
Side effects, safety, toxicity, danger
High doses of B vitamins can speed heart rate and cause insomnia.
I just had
blood work done and the results indicate my liver enzyme ALT level elevated to
46, which I know is borderline. It will be checked again in three months. I am
very particular about my diet so am perplexed at why it isn't normal. I do take
b-complex injections once a week so was wondering if this could be the reason?
There are many causes for an elevated ALT level and it is
difficult to know in any one individual what the cause is without more testing.
I have not heard of B complex injections causing this issue but I cannot rule it
out, either.
Weight gain or loss
Could you
please tell me if you are aware of any times when someone takes vitamin b
complex that they also experience weight gain?
We have not heard this before, but that does not mean it is not possible.
Dosage
I recently
found a b-complex vitamin which has reasonable amounts of each vitamin. It is
B-Right by Jarrow Formulas. This product comes in a capsule. I would like to
take about half of the dose daily. Do you think that if I open the capsule and only take half of the contents that i can be reasonably sure that I
am getting around half the dose of each vitamin? I want to keep the ratio of
each vitamin the same as to not create an imbalance.
Just because a company has put together a group of vitamins
together as a B complex formula -- such as the B-Right by Jarrow Formulas --
does not mean that this combination is what your body needs. As a rule I think
most B complex formulas have too high amounts and therefore
it is a good idea to take less. It is impossible to know for sure what the ideal
B complex combination would be for your body since your diet is different than
other people's diet and the type of foods you consume are likely to change over
time. Hence, for practical purposes, it is irrelevant whether taking half of the
capsule will provide the exact ratio in the formula.
I noticed that all the daily values were
not too much like many other b-vitamin products, but vitamin b-12 is 5,000 of
the DV%. Is this amount necessary and healthy to take on a daily basis? Also I
noticed it contains coenzyme-q-10, and I am 28 years of age, is it necessary for
me to start taking it?
The decision whether to take supplements is done case by case in
consultation with a health care provider. Only a small amount of oral vitamin B
12 is absorbed. It is a good idea to take breaks from the use of most
supplements, including B complex pills. Some people may decide to take a B
complex supplement only 2 or 3 times a week.
Combining with dietary supplements
My boyfriend
is taking SAM-e and B-complex vitamins, is there another type of sex enhancer
supplement that would be safe to take with them. I was interested with
Passion Rx but the web site did not recommend to take it with SAM-e. So, what is
an alternative natural supplement that has the same effect that Passion Rx
produces would you suggest?
SAM-e is a potent supplement that is best used by itself since
it can cause side effects of overstimulation, restlessness, and insomnia if
combined with a high dose B vitamin complex or herbs that have a stimulant
nature. Almost all herbs used for sexual enhancement can cause stimulation,
therefore we suggest not taking SAM-e the same day as these libido herbs.
I am a medical
doctor. You mentioned on your site that you think that perhaps 1-3 times RDA of
B complex should generally be enough. My question: When taking a high dose of
SAMe, e.g. 800mg, how much B complex do you think one should take, in order to
avoid homocysteine buildup, without unnecessarily aggravating possible
side-effects such as insomnia. I started looking at this up on pubmed, but
cannot easily get a clear answer. Further, do you think that taking B complex
once every several days would be effective, or is it too rapidly metabolized?
How concerned should I be about the homocysteine buildup? Is ALL of the B
complex significant, or can one take selective treatment (B12?). A patient of
mine is experiencing insomnia following SAMe and B-complex, and I would like to
taper the latter down, but want to do so responsibly. I also thought that
clarifying this would be of interest to many others.
These are difficult questions to answer since little research is
available and there could be enormous differences between individuals depending
on their diet, activity level, metabolism, age, etc. As a general rule I am not
concerned about the homocysteine aspect. I think 800 mg of SAM-e is too high and
I would rather focus on lowering the amount and taking small amounts of the Bs a
few times a week.