What is CoQ10?
CoQ10 – short for Coenzyme Q10 -- is a naturally occurring nutrient and
antioxidant found in each cell of the body. CoQ10 was first identified
by University of Wisconsin researchers in 1957. CoQ10 is
becoming more popular as more doctors find out about the benefits of
this nutrient, particularly in patients who are placed on statin drugs.
Benefit of CoQ10 supplements
Studies regarding the benefit of CoQ10 have mostly focused on
its benefit involving certain types of cardiovascular diseases, including
congestive heart failure and hypertension. However, CoQ10 may also benefit those
with high cholesterol and diabetes. Studies with CoQ10 and Parkinson's disease
have not yielded consistent results. We still have a long way to go to determine
the proper clinical role and benefit of CoQ10. In the meantime, do not assume
that the benefit of CoQ10 depends on the highest dose that you take. It is
possible that after a certain dosage, CoQ10 could lose its benefit. We don't
think more than 50 mg of CoQ10 is required by most people.
See also CoQ10 supplement (Coenzyme Q10) 30 mg, 50 mg, and 100 mg
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a review of several studies on various supplements and natural medicine topics, and
their practical interpretation by Ray Sahelian, M.D. We often discuss research
updates on the benefit of CoQ10. Also consider another form of CoQ10 called
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How Does CoQ10 work?
Each cell in the body needs a source of energy to survive, so cells
break down sugars, fats, and amino acids to make energy. Small
enclosures within cells that produce this energy are called
mitochondria. CoQ10 exists naturally in our mitochondria and carries
electrons involved in energy metabolism. CoQ10 is essential in the
production of adenosine triphosphate (ATP), the basic energy molecule of
each cell. Other mechanisms of action may include stabilization of
calcium dependent slow channels and alteration of prostaglandin
metabolism.
Co-Q10 benefit for Parkinson's disease
Benefit of CoQ10 for
energy production
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Overall benefit of CoQ10 pills
Many of my patients who take CoQ10 notice an increase in energy.
But some are under the misconception that the more CoQ10 they take, the
healthier they will be. Perhaps you have already heard of CoQ10 being
touted for heart health, vitality, and other benefits. But before you
take this interesting nutrient as a supplement, learning some simple
facts could help you make a more informed decision.
What Foods Contain CoQ10?
CoQ10 is found in foods, particularly in fish and meats, and small
amounts are found in nuts. There is little or no CoQ10 in grains,
vegetables or fruits. Hence, some vegetarians may not get adequate
amounts of this nutrient, although, fortunately, the body is able to
synthesize CoQ10 when dietary sources are not adequate. Dietary intake
of CoQ10 is about 2 to 5 mg per day.
CoQ10 Benefit
Studies with CoQ10 have mostly focused on its benefit involving certain
types of cardiovascular diseases, including congestive heart failure and
hypertension and to a certain extent for high cholesterol and in
diabetes. Not all the results have been positive and much more research
is needed before we determine the full benefits, side effects, and
appropriate dosage.
CoQ10 benefit Diabetes
CoQ10 may be beneficial in diabetics. It helps improve the function of
endothelial cells lining blood vessels and may slightly help with blood
sugar control.
CoQ10 benefit
Heart Attacks:
In a small trial of patients with new myocardial infarction, CoQ10 --
used in addition to aspirin and cholesterol-lowering drugs -- decreased
the likelihood of further cardiac events for at least one year after the
heart attack.
CoQ10 benefit
Heart Failure
A study in patients with heart failure showed improvement in functional
status, clinical symptoms, and quality of life in end stage heart
failure patients who were placed on CoQ10.
CoQ10 benefit
Hypertension
CoQ10 may help lower blood pressure by a small amount in some people.
CoQ10 benefit
Cholesterol
Individuals on cholesterol medicines of the statin class such as Lipitor,
Zocor, and others, may consider taking CoQ10 supplements since statins
decrease blood CoQ10 levels. Some doctors are routinely advising their
patients on statin drugs to take small amounts of CoQ10.
Side Effects of CoQ10
High dosages of CoQ10, such as more than 100 or 200 mg, can induce
restlessness, fatigue and insomnia. Long term side effects of high dose
CoQ10 use are not clear at this time. I usually do not recommend more
than 20 to 60 mg of CoQ10 daily on a long term basis without medical
supervision.
CoQ10 Dosage
CoQ10 is available in a variety of dosages ranging from 10 mg to 300 mg
per capsule, but most commonly in 30, 50, and 60 mg. I personally
believe that high doses are not needed, and may even be unhelpful or
detrimental. I’ve had patients who have reported fatigue when taking
dosages above 100 mg. Just as we recently discovered that high doses of
vitamin E, generally over 400 units, are not beneficial, or even
potentially harmful, we may eventually discover the same about CoQ10. I
would not feel comfortable recommending to my patients to take more than
50 mg or maximum 100 mg of CoQ10 a day, unless for the temporary
treatment of a medical condition.
CoQ10 is best taken in the morning, before or with breakfast.
CoQ10 benefit summary
CoQ10 is probably beneficial in certain cardiovascular conditions and as
an energy booster. Long-term therapy with 10 to 60 mg a few days a week
seems a reasonable option for many individuals. Fortunately, the pace of
CoQ10 research has increased over the past decade and the next few years
will provide us with additional information on the best way to take
advantage of this wonderful nutrient.
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Idebenone is a synthetic analogue of
coq10 used in Europe in the
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