Bioperine supplement health benefit and side effects, dosage, medical uses, combined with herbs such as curcumin complex by Ray Sahelian, M.D. piperine extract

Bioperine, a standardized piperine composition derived from black pepper extract. Made by Sabinsa, it is a standardized extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper). It contains 95 percent piperine, which has potential health benefits .

Sabinsa claims that Bioperine has been shown in clinical research to increase the absorption of nutrients in nutritional supplement formulations. However, whether this potential increase in absorption, even if true, makes practical significance and improves health is not clear since most herbal and nutritional products are sold in higher than normal required dosages and additional absorption, even if true, may or may not be beneficial. It is possible that the use of Bioperine may increase the side effects of certain supplements if it is true that the use of this product increases absorption. For the time being, it appears that the benefit - in terms of nutrient absorption - has more to do with a marketing agenda as opposed to real health benefit. However, it is also quite possible that it could well have benefits of its own - for instance as an antioxidant, anti-inflammatory, anti-tumor, etc - that would make it a helpful supplement. Many herbal extracts have some benefit even if they have not been studied that well.

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Black Pepper fruit extract

Bioperine does not appear to be irritating to the gastrointestinal tract.

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Absorption of nutrients
Will Bioperine help the body absorb supplements better?
    This is a claim the manufacturer makes but I have not seen enough data to know for sure and whether, practically speaking, it makes much difference. At this time I think that this product will help with the absorption of certain supplements, but I am not sure how safe it would be to consume it daily for weeks and months.

Dosage
I am looking to purchase a particular CoQ-10 supplement that contains 5 mg BioPerine. I need to supplement with CoQ-10, Is 5mg a high dose?
    Very few human studies with Bioperine have been published and the right dosage for long term use is not known. Would Bioperine supplement use for many months or years cause side effects? The answers are not in and therefore taking breaks is a good idea. CoQ10 has been studied more often and it may be better to take the supplements separately since one can take more time off from the Bioperine until more studies are published.

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Bioperine side effects, safety, risks
No significant Bioperine side effects have been reported at this time. Minor gastrointestinal discomfort or GI symptoms may occur with high doses.
   Not enough human studies have been done to determine the side effects of chronic supplementation. For the time being, it is a good idea to take 2 days off a week, and one full week off each month from the use of a Bioperine supplement. It is quite likely that the small amounts could provide health benefits while larger amounts could be toxic or damaging to the liver or other organs.

I find hair loss a side effect with 50 mg Bioperine with 1200 mg curcumin. Is this common or reversible?
    This is the first time we have had an email from someone reporting hair loss in relation to the use of these supplements. At this time I am not ready to believe there is a connection, but I will keep an open mind if others report the same.

Trademark and legal issues
November 2006 - Sabinsa Corporation announced that it has taken legal action against DNP International, Inc. in the United States District Court in New Jersey for infringement of Sabinsa's patents governing the use of BioPerine, a black pepper extract, and ForsLean, a Coleus forskohlii extract. Sabinsa has alleged in its complaint that DNP has been unlawfully marketing and distributing piperine and Coleus forskohlii for uses that Sabinsa researched and patented in the late-1990's. "Sabinsa is a pioneering company that is committed to the innovation of new products. The company is able to further its commitment by protecting these innovative products through obtaining patents," stated Dr. Muhammed Majeed, founder and CEO, Sabinsa Corporation. "We invest significant amounts of money each year into research to develop products that can be safely and confidently used by the nutritional supplement industry. Intellectual property allows us to bring the fruits of this research to the marketplace," added Muhammed Majeed.

2006 - The US Patent and Trademark Office (USPTO) has completed a formal review of Sabinsa Corporation's Patent, "Use of piperine as a bioavailability enhancer" and concluded that all points outlined within the patent are valid. Four examiners with the USPTO extensively reviewed the patent, which is one of 5 granted that surrounds Sabinsa's branded ingredient Bioperine, a standardized piperine composition derived from black pepper extract that the company claims has been shown in clinical research to increase the absorption of nutrients in nutritional supplement formulations. Sabinsa says, "This assessment reaffirms that Bioperine is the only black pepper extract that can legally be used in nutritional supplements for the purpose of enhancing the bioavailability of nutrients. This independent review ensures that all claims outlined in this patent are valid, and that companies selling piperine containing black pepper extracts for the express or implied purpose of nutrient absorption enhancement are clearly infringing on this patent," stated Todd Norton, president, Sabinsa Corporation.

About Sabinsa raw material supplier
Sabinsa Corporation, founded in 1988, is a manufacturer and supplier of herbal extracts, cosmeceuticals, minerals and specialty fine chemicals. Sabinsa's mission is to provide alternative and complementary natural products for human nutrition and well-being. Over the past nine years, Sabinsa has brought to market more than 50 standardized botanical extracts and privately funded several clinical studies in conjunction with prestigious institutions in support of these products. With more than 100 scientists working full time conducting ongoing research both in India and the United States, Sabinsa continues to develop and patent phytonutrients for the world market. All products intended for human consumption are certified Kosher. Bioperine is a Registered Trademark and a product of Sabinsa Corporation. ForsLean is a Registered Trademark and a product of Sabinsa Corporation.