March 11 2016
This substance is found in a number of plants including Artichoke leaf and celery.
Absorption and isomerization of caffeoylquinic acids from
different foods using ileostomist volunteers.
Eur J Nutr. 2013. Department of Chemistry, Division of Food Chemistry and Toxicology, University of Kaiserslautern, Erwin-Schroedinger-Str, Kaiserslautern, Germany.
Polyphenols are thought to play important roles in human nutrition and health but these health effects are dependent on their bioavailability. This study is one of a series with the aim of determining possible effects of food matrices on caffeoylquinic acid (CQA) bioavailability using ileostomy volunteers. After a CQA-free diet, ileostomists consumed coffee (746 μmol total CQA), and CQAs in excreted ileal fluid were subsequently identified and quantified with HPLC-diode array detection. In our previous studies, other food sources such as cloudy apple juice (358 μmol CQA) and apple smoothie (335 μmol CQA) were investigated with the same model. Interesterification of CQA from both apple matrices was observed during gastrointestinal passage, whereas CQA consumed in coffee was not influenced by interesterification reactions. Our results show that variations in food matrices and variations in phenolic composition have a major influence on intestinal bioavailability and interesterification of the investigated subclass of polyphenols, the CQAs.
Chemical constituents of fresh celery
Zhongguo Zhong Yao Za Zhi. 2009; Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang, China.
To study the chemical constituents of the whole plant of fresh celery (Apium graveolens). The constituents were isolated and purified by silica gel, Sephadex LH-20, ODS column chromatography, PTLC, HPLC, and their structures were elucidated on the basis of spectral evidences. Twenty compounds were obtained and identified as falcariondiol, (9Z) 1,9-heptadecadiene-4,6-diyne-3,8,11-triol, oplopandiol, bergapten, 5,8-dimethoxy psoralen, isofraxidin, eugenic acid, trans-ferulic acid, trans-cinnamic acid, p-hydroxyphenylethanol ferulate, caffeoylquinic acid, 5-p-trans-coumaroylquinic acid, sedanolide, lunularin, lunularic acid, 2-(3-methoxy-4-hydroxyphenol)-propane-1,3-diol, D-allitol, beta-sitosterol, benzolic acid, succinic acid.
Evaluation of free radical scavenging and antihemolytic activities of quince (Cydonia
oblonga) leaf: a comparative study with green tea (Camellia sinensis).
Food Chem Toxicol. 2009. Costa RM, Magalhães AS, Pereira JA, Andrade PB, Valentão P, Carvalho M. CEBIMED, Faculdade de Ciências da Saúde, Universidade Fernando Pessoa, R. Carlos da Maia, Porto, Portugal.
This study aimed to determine the phenolic profile and to investigate the antioxidant potential of quince (Cydonia oblonga) leaf, comparing it with green tea (Camellia sinensis). For these purposes, methanolic extracts were prepared and phenolics content of quince leaf was determined by HPLC/UV. The antioxidant properties were assessed by Folin-Ciocalteu reducing capacity assay and by the ability to quench the stable free radical 2,2'-diphenyl-1-picrylhydrazyl (DPPH) and to inhibit the 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative hemolysis of human erythrocytes. 5-O-Caffeoylquinic acid was found to be the major phenolic compound in quince leaf extract. Quince leaf exhibited a significantly higher reducing power than green tea. Quince leaf extracts showed similar DPPH radical scavenging activities but significantly higher than those presented by green tea. Under the oxidative action of AAPH, quince leaf methanolic extract significantly protected the erythrocyte membrane from hemolysis in a similar manner to that found for green tea (IC(50) mean value of 30 and 24 mug/ml, respectively. These results point that quince leaf may have application as preventive or therapeutic agent in diseases in which free radicals are involved.
Caffeoylquinic acid derivatives from leaves of Lonicera japonica
Zhongguo Zhong Yao Za Zhi. 2009. Tangshan Vocational and Technical College, Tangshan, China
To study the caffeoylquinic acid derivatives from the leaves of Lonicera japonica. The compounds were isolated by column chromatography and identified on the basis of physico-chemical constants and spectral analysis. Five caffeoylquinic acid derivatives were isolated, and their structures were identified as 3,4-di-O-caffeoyl quinic acid methyl ester, 5-O-caffeoyl quinic acid methyl ester, 3,4-di-O-caffeoyl quinic acid, 1,3-di-O-caffeoyl quinic acid and chlorogenic acid.
Pharmacognosy Res. 2014. Caffeoylquinic acids in leaves of selected Apocynaceae species: Their isolation and content. Three compounds isolated from the methanol (MeOH) leaf extract of Vallaris glabra (Apocynaceae) were those of caffeoylquinic acids (CQAs). This prompted a quantitative analysis of their contents in leaves of V. glabra in comparison with those of five other Apocynaceae species (Alstonia angustiloba, Dyera costulata, Kopsia fruticosa, Nerium oleander, and Plumeria obtusa), including flowers of Lonicera japonica (Japanese honeysuckle), the commercial source of chlorogenic acid (CGA).