Carnosine supplement benefit and side effect, as antioxidant, dosage of 250 mg and 500 mg capsules, by Ray Sahelian, M.D. a review of medical uses and benefits, also used as eye drops

March 15 2014

Carnosine is a small molecule composed of the amino acids histidine and alanine. This dipeptide is found in relatively high concentrations in several body tissues—most notably in skeletal muscle, heart muscle, skin, stomach, nerve tissue and brain. The exact biological role is not well understood, but many studies indicate that carnosine has antioxidant potential. Carnosine may also act as a neurotransmitter (chemical messenger in the nervous system). Carnosine has been called a longevity nutrient since laboratory studies on tissues indicate that it can delay senescence and provoke cellular rejuvenation in cultured human fibroblasts. Carnosine has been called the anti-aging and anti-oxidant dipeptide. The exact role of carnosine supplementation in human health is not clear at this time but carnosine appears to be a promising nutrient with much potential.

Carnosine studies and benefit
This nutrient has been studied for its benefits as a strong antioxidant, in protecting nerve cells in the brain, autism, vision and eye health, diabetes, and other conditions.

Purchase L Carnosine 500 mg per pill, 30 Capsules - Pharmaceutical Grade

l-carnosine-500mg-front-Sahelian.jpgL-Carnosine is naturally produced in the body by the enzyme carnosine synthetase. This nutrient supports healthy aging and cellular rejuvenation by its effects on two mechanisms: Glycosylation and free radical damage. Glycosylation is the oxidation of proteins by glucose resulting in cross-linking of proteins and which is implicated in loss of cell function, genome integrity and accelerated aging.  It also protects the aging process of the brain by retarding lipid peroxidation and stabilizing cell membranes.

 

 

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Carnosine (alanylhistidine) 500 mg each pill

Usage: Take half or 1 carnosine capsule before or with breakfast a few times a week, or as directed by your qualified health consultant.

Q. Dr. Kyriazis, a leading anti-aging MD in the UK, based on his human trials of carnosine and current research states the current marketed dosing is based upon studies done with mice and cancer patients and  that dosage of 100-200mg are effective in humans while doses greater than 500 mg show adverse and reverse effects. Obviously there is a dosage transition area between 200 and 500. This doctor recommends ideally - 100 to 150 mg a day. Your comment on this article would be highly appreciated.
    A. Nobody knows for sure what the ideal dosage is in humans, and every person is different. However as a general guideline, I believe the lower amounts are probably just fine and people can open a 500 mg capsule and take a portion of it a few times a week.

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Alzheimer's disease prevention
Anti-crosslinking properties of carnosine: significance of histidine.
Life Sci. 2004.
Carnosine is a potential treatment for Alzheimer's disease. There is evidence that it prevents oxidation and glycation, both of which contribute to the crosslinking of proteins; and protein crosslinking promotes beta-amyloid plaque formation.

Anti-aging studies
Glycation plays important roles in aging and in diabetes and its secondary complications. Carnivorous diets contain this potential anti-glycating agent, whereas vegetarians may lack intake of the dipeptide.

Use of carnosine as a natural anti-senescence drug for human beings.
Biochemistry 2000.
Apart from the function of protecting cells from oxidation-induced stress damage, carnosine appears to be able to extend the lifespan of cultured cells, rejuvenate senescent cells, inhibit the toxic effects of amyloid peptide (A beta), malondialdehyde, and hypochlorite to cells, inhibit glycosylation of proteins and protein-DNA and protein-protein cross-linking, and maintain cellular homeostasis. Also, carnosine seems to delay the impairment of eyesight with aging, effectively preventing and treating senile cataract and other age-related diseases

l Carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts.
Biochem Biophys Res Commun. 2004.
Telomere is the repetitive DNA sequence at the end of chromosomes, which shortens progressively with cell division and limits the replicative potential of normal human somatic cells. l Carnosine, a naturally occurring dipeptide, has been reported to delay the replicative senescence, and extend the lifespan of cultured human diploid fibroblasts. In this work, we studied the effect of carnosine on the telomeric DNA of cultured human fetal lung fibroblast cells. Cells continuously grown in carnosine exhibited a slower telomere shortening rate and extended lifespan in population doublings. We suggest that the reduction in telomere shortening rate and damages in telomeric DNA made an important contribution to the life-extension effect of carnosine.

Cancer chemotherapy drug, protection from heart damage
Influence of carnosine on the cardiotoxicity of doxorubicin in rabbits.
Pol J Pharmacol. 2003.
The aim of this study was to establish the effect of naturally occurring antioxidant carnosine on the doxorubicin induced cardiotoxicity in a rabbit model. The histopathological studies revealed smaller damage of cardiac muscle in rabbits which received doxorubicin with carnosine in comparison to animals receiving doxorubicin alone. Carnosine seems to protect heart tissue during doxorubicin administration.

Carnosine helpful in autism
From the day she was born, Betty seemed different from other infants. At an age when most infants enjoy interacting with people and exploring their environment, Betty sat motionless in her crib and didn't respond to rattles or other toys. It wasnít too long before Betty was diagnosed with autism. Unfortunately, modern medicine has little to offer as a cure for this condition. But supplements may be helpful. Researchers at the Autism and Epilepsy Specialty Services in Lake Bluff, Illinois, investigated 31 children with autism in an 8-week, double-blinded study to determine if carnosine would result in changes. The children received 800 mg a day and were compared with a group of children on placebo. After 8 weeks, children given carnosine showed statistically significant improvements on several tests including an improvement in vocabulary and recognizing a picture.
     Dr. Sahelian says: L-carnosine is sold in health food stores most commonly in capsules of 500 mg. It would be worthwhile to try 100 to 200 mg of this nutrient before breakfast and lunch for a few weeks under a pediatricianís supervision. The dose would be much less than in adults.

Diabetes research
Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1.
Diabetes. 2005.
DNA polymorphisms were determined in 135 case (diabetic nephropathy) and 107 control (diabetes without nephropathy) subjects. The effect of carnosine on the production of extracellular matrix components and transforming growth factor-beta (TGF-beta) after exposure to d-glucose was studied in cultured human podocytes and mesangial cells, respectively. Carnosine inhibited the increased production of fibronectin and collagen type VI in podocytes and the increased production of TGF-beta in mesangial cells. Diabetic patients with the CNDP1 Mannheim variant are less susceptible for nephropathy. Carnosine protects against the adverse effects of high glucose levels on renal cells.

Eyesight and vision, cataracts
Carnosine eye drops could be used as a potent antioxidant to reduce certain types of vision disorders. Those who wish to improve distant and close vision, along with day and night vision, should consider Eyesight Rx, a tablet that melts under the tongue and improves eyesight within a few days.

Topical N-Acetyl-carnosine eyedrops shows potential for the treatment and prevention of cataracts. A study with rabbits indicates that carnosine reduces the cardiac toxicity from the use of the chemotherapeutic drug doxorubicin. Another area of potential benefit for carnosine is diabetic nephropathy.

I am trying to locate at least 2% N-Acetyl Carnosine eye drops for my 13 year old English Setter who, unfortunately, now has mature cataracts and is virtually blind. The 1% drops by Bright Eyes III were a waste of my money. Please, if there is anywhere that i can purchase NAC liquid drops, let me know.
    Since products that enter the eye have to be manufactured in a sterile manner, we are cautious in recommending any companies that make NAC liquid drops since we cannot be sure of their manufacturing and quality control processes.

Efficacy of N-acetyl- carnosine in the treatment of cataracts. Drugs R D 2002

Kidney disease
Dietary supplementation of L-carnosine prevents ischemia/reperfusion-induced renal injury in rats.
Biol Pharm Bull. 2005.
Our findings strongly suggest that Lcarnosine supplementation is useful as a prophylactic treatment in the development of the ischemic acute renal failure.

Dose-dependent effects of L carnosine on the renal sympathetic nerve and blood pressure in urethane-anesthetized rats.
Am J Physiol Regul Integr Comp Physiol. 2004
The physiological function of carnosine (beta-alanyl-L-histidine) synthesized in mammalian muscles until recently has been unclear. Previously, we observed that intravenous injection of carnosine suppressed renal sympathetic nerve activity (RSNA) in urethane-anesthetized rats, and carnosine administered via the diet inhibited the elevation of blood pressure (BP) in hypertensive rats. To identify the mechanism, we examined effects of IV or intra-lateral cerebral ventricular (LCV) injection of various doses of carnosine on RSNA and BP in urethane-anesthetized rats. Lower doses of carnosine significantly suppressed RSNA and BP, while higher doses elevated RSNA and BP. These findings suggest that low-dose carnosine suppresses and high-dose carnosine stimulates RSNA and BP, that the SCN and histaminergic nerve are involved in the activities, and that carnosine acts in the brain and possibly other organs.

Smell, olfactory sense
Is carnosine a naturally occurring suppressor of oxidative damage in olfactory neurones?
Rejuvenation Res. 2004.
Neurons from olfactory lobes of Alzheimer's patients exhibit oxidative stress and it is well known that olfactory dysfunction frequently accompanies neurodegeneration. The olfactory lobe is normally enriched in carnosine, a relatively non-toxic (and sometimes abundant) dipeptide which possesses functions (anti-oxidant, antiglycator, scavenger of zinc and copper ions, toxic aldehydes and protein carbonyls) that are likely to suppress oxidative stress. It is suggested that its therapeutic potential should be explored in olfactory tissue.

I have stumbled across your site multiple times and your information seems to hold true with my experiences with some of the herbs, vitamins, supplements... you discuss. I just saw that you mentioned there may be a link between carnosine and smell. Earlier today I purchased some before reading about it on your site and knowing only of potential stomach liver and learning benefits and the moment I took it I noticed my sense of smell became much more keen as it used to be. Just wanted to share the info with you and thank you for the info you provide as I can see that you are very knowledgeable.

Physiological role
First isolated in 1900, carnosine is a dipeptide commonly present in human and animal tissue, and in particular in skeletal muscle cells; it is responsible for a variety of activities related to the detoxification of the body from free radical species and the by-products of membrane lipids peroxidation. Carnosine also has membrane-protecting activity, proton buffering capacity, formation of complexes with transition metals, and regulation of macrophage function. It has been proposed that carnosine could act as a natural scavenger of dangerous reactive aldehydes from the degradative oxidative pathway of endogenous molecules such as sugars, polyunsaturated fatty acids and proteins. Carnosine is a potent and selective scavenger of alpha,beta-unsaturated aldehydes, typical by-products of membrane lipids peroxidation and considered second messengers of the oxidative stress, and inhibits aldehyde-induced protein-protein and DNA-protein cross-linking in neurodegenerative disorders such as Alzheimer's disease, in cardiovascular ischemic damage, and in inflammatory diseases.

Emails
I just thought I would bring to your attention a website in which I feel is spreading misinformation. Dr. E.K. Schandl is saying carnosine causes carnosinemia which is an inherited condition but to hear him tell it, supplemental carnosine causes an overload leading to this condition. I feel he is misleading people. He needs to be held accountable for his misleading statements that aren't really backed up by any scientific research. The only research he cites concerns people with the inherited condition. I wrote him about my concerns and he wrote back with a very insulting comment. I was wondering if you knew of any avenue we could take to stop this man from deterring people from such a wonderful supplement.
    Although we disagree with his viewpoint on carnosine (we feel it is safe and beneficial in 100 to 250 mg doses taken a few days a week), we feel each person has a right to their own opinion and whatever they wish to say on their website.

Would Carnosine in a liquid form be effective in the treatment of autism. Would it tend to degrade into alanine and histidine - and/or would this be a benefit or problematic? What's the current thinking? Would a liquid form still be of benefit to autism?
    I have not seen studies regarding the liquid form of carnosine, we don't see how it could have advantages over the carnosine capsules. In fact, a capsule can be opened and part of the carnosine used in water or juice.

I get an allergic response (sinus problems, skin rash) to oral carnosine at 500-1000mg, I could lower the dose but I'm curious why this happens (most people can take 1000mg for antiaging (antiglycation) effects). I'm not allergic otherwise to any food. I believe it's a histamine release but I find it strange. Hope to get a reply and keep up the good site!
    Carnosine converts into histidine which converts into histamine. Perhaps too high of a carnosine dose can shift the metabolic pathway towards histamine. I don't think more than 100 mg of carnosine is needed on a regular basis. Too much of a good thing can sometimes be harmful.