Celery Seed extract by Ray Sahelian, M.D.

Celery seed is the dried fruit of Apium graveolens L. which is related, but not identical, to the vegetable celery plant. The tiny brown seeds have a celery-like flavor and aroma.

Celery Seed Composition
Celery seed has several sesquiterpenoid glucosides (celerioside A-E), phthalide glycosides (celephtalide A-C),  aromatic compound glucosides, norcarotenoid glucosides, and a lignan glucoside.

Benefit of Celery Seed
Very little research is available on celery seed. Celery seed extract may perhaps be helpful in liver cancer. In folklore, celery seeds have aphrodisiac properties.

Celery Seed Research Update
Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism and altered hepatic foci development.
Cancer Lett. 2005 Apr 18;221(1):11-20.
The chemopreventive activity of methanolic extract of Apium graveolens seeds (celery seeds) has been investigated against Solt Farber protocol of hepatocarcinogenesis, oxidative stress and induction of positive foci of gamma-GT in the liver of Wistar rats. The prophylactic treatment of celery seeds extract protected dose dependently against diethylnitrosoamine (DEN)+2-acetylaminofluorine (AAF)+partial hepatectomy (PH) induced hepatocarcinogenesis. On the basis of the above results it can be said that celery seed is a potent plant against experimentally induced hepatocarcinogenesis in Wistar rats.

Potential of crude seed extract of celery, Apium graveolens L., against the mosquito Aedes aegypti (L.) (Diptera: Culicidae).
J Vector Ecol. 2004 Dec;29(2):340-6.
Crude seed extract of celery, Apium graveolens, was investigated for anti-mosquito potential, including larvicidal, adulticidal, and repellent activities against Aedes aegypti, the vector of dengue haemorrhagic fever. The ethanol-extracted A. graveolens possessed larvicidal activity against fourth instar larvae of Ae. aegypti with LD50 and LD95 values of 81.0 and 176.8 mg/L, respectively. The abnormal movement observed in treated larvae indicated that the toxic effect of celery seed extract was probably on the nervous system. In testing for adulticidal activity, this plant extract exhibited a slightly adulticidal potency with LD50 and LD95 values of 6.6 and 66.4 mg/cm2, respectively. It showed repellency against Ae. aegypti adult females with ED50 and ED95 values of 2.03 and 28.12 mg/cm2, respectively. It also provided biting protection time of 3 h when applied at a concentration of 25 g%. Topical application of the ethanol-extracted celery seed extract did not induce dermal irritation. No adverse effects on the skin or other parts of the body of human volunteers were observed during 3 mo of the study period or in the following 3 mo, after which time observations ceased. Celery seed extract, therefore, can be considered as a probable source of some biologically active compounds used in the development of mosquito control agents, particularly repellent products.

Emails regarding Celery
Q. I get a relaxed feeling when I eat a lot of celery.

Q. I have seen articles indicating that celery seed extract and celery are beneficial for lowering high blood pressure. I don't believe I have seen celery seed on your website. Do you have any information on it and would you be carrying a celery seed supplement in the future?
   A. We have not looked into celery seed in any detail yet, but we will look for more research in the future.