What you will find on this Cetyl Myristoleate page:
Cetyl Myristoleate and Arthritis Information
Joint Power Rx with Cetyl Myristoleate-- formulated by Ray Sahelian, M.D.
Cetyl Myristoleate supplement information

Cetyl myristoleate is the common name for cis-9-cetyl myristoleate, a compound synthesized from cetyl alcohol and mysristoleic acid. The rational for the use of cetyl myristoleate is that it may inhibit the production of inflammatory prostaglandins and leukotrienes.
   Cetyl myristoleate was discovered in 1972 by Harry W. Diehl, Ph.D., a researcher at the National Institutes of Health. At the time, Dr. Diehl was responsible for testing anti-inflammatory drugs on lab animals. In order for him to test the drugs, he first had to artificially induce arthritis in the animals by injecting a heat-killed bacterium called Freund’s adjuvant. Dr. Diehl discovered that Swiss albino mice did not get arthritis after injection of Freund’s adjuvant. Eventually, he was able to determine that cetyl myristoleate was the factor present naturally in mice that was responsible for this protection. When cetyl myristoleate was injected into various strains of rats, it offered the same protection against arthritis. It has been proposed that cetyl myristoleate acts as a joint “lubricant” and anti-inflammatory agent.

Cetyl Myristoleate, 400 mg
Developed by Ray Sahelian, M.D.
Cetyl Myristoleate Fatty Acid Complex for Joints

This cetyl myristoleate product contains concentrated extract of the fatty acid cerasomal-cis-9-acetyl-myristoleate from natural bovine source. Cetyl myristoleate is not found in any vegetable oils or other common foods. Cetyl myristoleate is found in low amounts in animal connective tissue. Cetyl Myristoleate contains the identical compound referenced in published clinical trials.

Usage: Take 1 Cetyl myristoleate capsule daily in the morning, or as directed by your qualified health consultant.
Cetyl Myristoleate Supplement Facts
Cetyl Myristoleate Extract  - 400 mg (Fatty Acid Complex)

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Joint Power Rx with Cetyl Myristoleate
Formulated by Ray Sahelian, M.D.

Because joint pain is so debilitating, glucosamine and chondroitin alone are sometimes not enough. This powerful formula includes cetyl myristoleate and several additional herbal extracts and nutrients that play a role in joint health.  

Ingredients in Joint Power Rx: Glucosamine sulfate (from shellfish), Chondroitin sulfate, MSM, Cetyl myristoleate complex, Boswellia serrata extract, Cat's claw extract, Devil's claw extract, Grape seed extract, Sea Cucumber, and Turmeric.

Click the link in blue above for Cetyl myristoleate CMO

Cetyl myristoleate Research Update
People with the wear-and-tear kind of arthritis of the knee may benefit from a proprietary cream containing a blend of cetylated fatty acids. Pain relief and improved functional performance may be experienced as early as half an hour after the cream is applied to the affected joint.

Synthesis of cetyl myristoleate and evaluation of its therapeutic efficacy in a murine model of collagen-induced arthritis.
Pharmacol Res. 2003 Jan;47(1):43-7.
University of Nevada School of Medicine, Reno, NV
Cetyl myristoleate was reported by Diehl and May [J Pharm Sci 83 (1994) 296] to block inflammation and prevent adjuvant-induced arthritis in rats. To verify this earlier work, we have synthesized pure Cetyl myristoleate and tested its anti-arthritic properties in a collagen-induced arthritis model in DBA/1LacJ mice. Multiple intraperitoneal injections of Cetyl myristoleate resulted in a significantly lower incidence of disease and caused a modest but significant diminution in clinical signs in those mice that developed arthritis. Cetyl myristoleate administered in daily oral doses of 20 mg kg(-1) also reduced the incidence of arthritis and caused a small reduction in the clinical signs in mice that developed arthritis. Although the protective effect of Cetyl myristoleate in collagen-induced arthritis observed in the present study was less dramatic than that reported earlier, our results confirm the anti-arthritic properties of pure Cetyl myristoleate.

Cetylated fatty acids improve knee function in patients with osteoarthritis.
Hesslink R Jr, et al.  Hesslink Ventures, San Diego, California
J Rheumatol. 2002 Aug;29(8):1708-12.
To determine the benefit of cetylated fatty acids (CFA) on knee range of motion and function in patients with osteoarthritis (OA). Sixty-four patients with chronic knee OA were evaluated at baseline and at 30 and 68 days after consuming either placebo (vegetable oil; n = 31) or CFA (Celadrin; n = 33). Evaluations included physician assessment, knee range of motion with goniometry, and the Lequesne Algofunctional Index (LAI). After 68 days, patients treated with CFA exhibited significant increase in knee flexion (10.1 degrees) compared to patients given placebo (1.1 degrees). Neither group reported improvement in knee extension. Patient responses to the LAI indicated a significant shift towards functional improvement for the CFA group (-5.4 points) after 68 days compared to a modest improvement in the placebo group (-2.1 points). Compared to placebo, CFA provides an improvement in knee range of motion and overall function in patients with OA of the knee. CFA may be an alternative to the use of nonsteroidal antiinflammatory drugs for the treatment of OA.

Cetyl myristoleate isolated from Swiss albino mice: an apparent protective agent against adjuvant arthritis in rats.
Diehl HW, May EL.
Department of Pharmacology, Medical College of Virginia, Richmond
 J Pharm Sci 1994 Mar;83(3):296-9.
Cetyl myristoleate Cetyl myristoleate was isolated from National Institutes of Health, general purpose, Swiss albino mice that were immune to the polyarthritis induced in rats with Freund's adjuvant. This substance, or material synthesized from cetyl alcohol and myristoleic acid, afforded good protection against adjuvant-induced arthritic states in rats. In limited comparisons, cetyl oleate, also found in Swiss albino mice, gave lesser protection, whereas cetyl myristate and cetyl elaidate, the trans-isomer of cetyl oleate, appeared to be virtually ineffective. Dosage of the protective compound as well as the site of injection of Freund's adjuvant was important.

Cetyl Myristoleate emails
Q. I am interested to know how much actual cerasomal-cis-9- cetyl myristoleate is in your product? Another website (which) claims to be the original says that you need something like 238 mg of cerasomal-cis-9- cetyl myristoleate in each serving. What is your comment?
   A. There has been only one human studies with CMO. It takes dozens of studies to determine ideal dosages of drugs or supplements, and hence whoever is saying 238 mg of cerasomal-cis-9- cetyl myristoleate is needed apparently does not have a good understanding of the scientific method.