Cetyl myristoleate is the common name for cis-9-cetyl myristoleate,
a compound synthesized from cetyl alcohol and mysristoleic acid. The
rational for its use is that it may inhibit the production of
inflammatory prostaglandins and leukotrienes.
Cetyl myristoleate was discovered in 1972 by Harry W. Diehl, Ph.D., a researcher at the National Institutes of Health. At the time, Dr. Diehl was responsible for testing anti-inflammatory drugs on lab animals. In order for him to test the drugs, he first had to artificially induce arthritis in the animals by injecting a heat-killed bacterium called Freund’s adjuvant. Dr. Diehl discovered that Swiss albino mice did not get arthritis after injection of Freund’s adjuvant. Eventually, he was able to determine that cetyl myristoleate was the factor present naturally in mice that was responsible for this protection. When it was injected into various strains of rats, it offered the same protection against arthritis. It has been proposed that this nutrient acts as a joint “lubricant” and anti-inflammatory agent.
As of April 2015 I could not find recent human research with this supplement.
Myristoleate capsule, 400 mg
Cetyl Myristoleate Fatty Acid Complex for Joints
This product contains concentrated extract of the fatty acid cerasomal-cis-9-acetyl-myristoleate from natural bovine source. It is not found in any vegetable oils or other common foods. It is found in low amounts in animal connective tissue.
Ingredients in Joint Power Rx: Glucosamine sulfate (from shellfish), Chondroitin sulfate, MSM, Cetyl myristoleate complex, Boswellia serrata extract, Cat's claw extract, Devil's claw extract, Grape seed extract, Sea Cucumber, and turmeric.
Usage: Take 1 Cetyl myristoleate capsule daily in the morning, or as directed by your qualified health consultant.
Cetyl Myristoleate Extract 400 mg (Fatty Acid Complex)
Buy Cetyl Myristoleate supplement or Joint Power Rx
Cetyl myristoleate cream
People with the wear-and-tear kind of arthritis of the knee may benefit from a proprietary cream containing a blend of cetylated fatty acids. Pain relief and improved functional performance may be experienced as early as half an hour after the cream is applied to the affected joint.
For horses, dogs and cats
Can you tell me if this natural product works for animals such as horses, dogs and cats?
I have not seen studies regarding the use of this natural product for animals but I suspect if there are benefits to humans then it is quite likely that the results would have similar effects in animals.
Synthesis of cetyl myristoleate and evaluation of its therapeutic efficacy in a murine model of collagen-induced arthritis.
Pharmacol Res. 2003. University of Nevada School of Medicine, Reno, NV
Cetyl myristoleate was reported by Diehl and May [J Pharm Sci 83 (1994)] to block inflammation and prevent adjuvant-induced arthritis in rats. To verify this earlier work, we have synthesized pure Cetyl myristoleate and tested its anti-arthritic properties in a collagen-induced arthritis model in DBA/1LacJ mice. Multiple intraperitoneal injections resulted in a significantly lower incidence of disease and caused a modest but significant diminution in clinical signs in those mice that developed arthritis. Cetyl myristoleate administered in daily oral doses of 20 mg kg(-1) also reduced the incidence of arthritis and caused a small reduction in the clinical signs in mice that developed arthritis. Although the protective effect in collagen-induced arthritis observed in the present study was less dramatic than that reported earlier, our results confirm the anti-arthritic properties of pure Cetyl myristoleate.
Cetylated fatty acids improve knee function in patients with osteoarthritis.
J Rheumatol. 2002. Hesslink Ventures, San Diego, California
To determine the benefit of cetylated fatty acids (CFA) on knee range of motion and function in patients with osteoarthritis (OA). Sixty-four patients with chronic knee OA were evaluated at baseline and at 30 and 68 days after consuming either placebo or CFA (Celadrin; n = 33). Evaluations included physician assessment, knee range of motion with goniometry, and the Lequesne Algofunctional Index (LAI). After 68 days, patients treated with CFA exhibited significant increase in knee flexion (10 degrees) compared to patients given placebo (1 degree). Neither group reported improvement in knee extension. Patient responses to the LAI indicated a significant shift towards functional improvement for the CFA group (-5.4 points) after 68 days compared to a modest improvement in the placebo group (-2.1 points). Compared to placebo, CFA provides an improvement in knee range of motion and overall function in patients with OA of the knee. CFA may be an alternative to the use of nonsteroidal antiinflammatory drugs for the treatment of OA.
Cetyl myristoleate isolated from Swiss albino mice: an apparent protective agent against adjuvant arthritis in rats.
Diehl HW, May EL. Department of Pharmacology, Medical College of Virginia, Richmond. J Pharm Sci 1994.
Cetyl myristoleate was isolated from National Institutes of Health, general purpose, Swiss albino mice that were immune to the polyarthritis induced in rats with Freund's adjuvant. This substance, or material synthesized from cetyl alcohol and myristoleic acid, afforded good protection against adjuvant-induced arthritic states in rats. In limited comparisons, cetyl oleate, also found in Swiss albino mice, gave lesser protection, whereas cetyl myristate and cetyl elaidate, the trans-isomer of cetyl oleate, appeared to be virtually ineffective. Dosage of the protective compound as well as the site of injection of Freund's adjuvant was important.
I am interested to know how much actual cerasomal-cis-9- cetyl myristoleate is in your product? Another website (which) claims to be the original says that you need something like 238 mg of cerasomal-cis-9- cetyl myristoleate in each serving. What is your comment?
There has been only one human studies with CMO. It takes dozens of studies to determine ideal dosages of drugs or supplements, and hence whoever is saying 238 mg of cerasomal-cis-9- cetyl myristoleate is needed apparently does not have a good understanding of the scientific method.
My mom has rheumatoid arthritis and she is taking a
product called Cetyl Mobililty and it contains magnesium zinc copper manganese
mixed fatty acid esters (cetyl myristoleate), cetyl myristate, cetyl
palmitoleate, cetyl laurate, cetyl palmitate, cetyl oleate) and type 11 collagen
and other ingredients: corn starch, hydroxypropyl methylcellulose, magnesium
stearate, sillicon dioxide and i want to know if you have a similar product and
some advise. My mom who is taking this product have seen some improvements.
We are not familiar with this Cetyl Mobility but you may wish to review our page on rheumatoid arthritis for some ideas.
I am a rheumatologist and have a patient with
psoriatic arthritis who has elected to stop her evidence based medications and
try cetyl myristoleate. As this disease has a multitude of complications, I was
hoping you could ease my mind and provide me evidence for the anti-inflammatory
effects of this product. She also has requested that I contact you personally
(as your name is on the bottle). I would greatly appreciate a copy of your
studies or evidence for the claims made on the package.
The bottle of this product does not make any claims that this nutrient treats any diseases, including psoriatic arthritis. There have been some preliminary studies that this substance has an anti-inflammatory effect. Before using any supplements patients need to discuss with their physician to make sure it is appropriate for their condition and the physician needs to keep an open mind and review the studies regarding such natural supplements since much of this research is often not mentioned or reviewed in standard medical journals.