natural treatment with supplements
by Ray Sahelian, M.D.
march 23 2014
Chloasma) is a condition in which areas of the skin become darker than the surrounding skin. This is called hyperpigmentation. Chloasma generally occurs on the face, particularly the forehead, cheeks and upper lip. The dark patches often appear on both sides of the face in a nearly identical pattern. The darker-colored patches of skin can be any shade, from tan to deep brown. Rarely, these dark patches may appear on other sun-exposed areas of the body. Chloasma is also known as melasma.
Proanthocyanidin and chloasma
Grape seed extract provides a concentrated source of polyphenols, most of which are proanthocyanidins.
Oral intake of
proanthocyanidin rich extract from grape
seeds improves chloasma.
Phytother Res. 2004. Research and Development Division, Kikkoman Corporation, Noda City, Chiba, Japan.
Chloasma (melasma), an acquired hypermelanosis, is often recalcitrant to various treatments and an amenable, as well as safe, pigment-reducing modality is needed. We investigated that the reducing effect of proanthocyanidin, a powerful antioxidant, on chloasma in a one-year open design study. Proanthocyanidin-rich grape seed extract was orally administered to 12 Japanese woman candidates with chloasma for 6 months between August 2001 and January 2002 and to 11 of these 12 for 5 months between March and July 2002. Clinical observation, L* value (lightening) and melanin index, and size (length and width) measurements of chloasma were performed throughout the study period. The first 6 months of grape seed extract intake improved or slightly improved chloasma in 10 of the 12 women and following 5 months of intake improved or slightly improved chloasma in 6 of the 11 candidates. Grape seed extract is effective in reducing the hyperpigmentation of women with chloasma. The beneficial effects of grape seed extract was maximally achieved after 6 months and these was no further improvement after this period. The latter grape seed extract intake for 5 months may prevent chloasma from becoming worse prior to the summer season. Grape seed extract is safe and useful for improving chloasma.