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Citrus Bioflavonoids by
Ray Sahelian, M.D.
(natural herbs listings)
Bioflavonoids are a group of plant pigments that are responsible for the
colors of many flowers and fruits. Citrus bioflavonoids are those
bioflavonoids, or flavonoids, found in citrus fruits such as lemon, orange,
tangerine, grapefruit, etc.
Citrus bioflavonoids possess antioxidant
activities, which help fight poor health and aging. Citrus bioflavonoids
have been investigated for their biological activity, with both
anti-inflammatory and -carcinogenic effects being reported. Flavonoids are
a subset of a larger group of beneficial plant substances known as
Polyphenols.
Eyesight Rx with Citrus Bioflavonoids
5 sublingual tablets in a foil pack
Supports Healthy Vision
Physician Formulas
Developed by Ray Sahelian, M.D.

Unlike some vision products that provide nutrients and
herbs for long term healthy eyesight support, and prevention of visual
impairment, but don't seem to have much of an immediate effect on visual
acuity, Eyesight Rx was formulated to provide a quick and noticeable
eyesight improvement within hours or days of use.
Reports from Eyesight Rx users indicate enhanced clarity of vision, colors
being brighter, better focus, and overall improvement in close and
distance vision. We've had reports of some people noticing this effect
within a half hour, while most people notice improved eyesight within
hours. Still others will realize their eyesight is sharper the next
morning when they take their second dose.
Supplement Facts:
Serving size: One Third tablet
servings per container: 15
Amount per serving:
Vitamin C - 10 mg - 16% Daily Value
(Ascorbic acid)
Proprietary Blend 190mg*
Citrus bioflavonoids
(eriocitrin, hesperidin,
flavonols,
flavones, flavonoids,
naringenin, and quercetin)
Mixed carotenoids
(alpha carotene,
astaxanthin,
beta carotene, cryptoxanthin,
Lutein,
Lycopene,
Zeaxanthin)
Bilberry
extract (Vaccinium myrtillus)
Eyebright
extract (Euphrasia officianales)
Jujube extract (Zizyphus jujube)
Ginkgo biloba
(Ginkgo biloba)
Suma extract (Pfaffia paniculata)
Mucuna pruriens
extract (Cowhage)
Cinnamon (Cinnamomum zeylanicum)
Lycium berry extract (Lycium Barbarum)
also known as Goji Berry
Sarsaparila (Sarsaparilla Smilax)
Alpha Lipoic Acid
Suggested use: Break the tablet with your front teeth and melt a third under
your tongue. Save the rest for another time.
Click Eyesight Rx to order this product or to order Lutein, Carotenoids,
and other vision supporting supplements available at Physician Formulas
Subscribe to a
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a month we email you a brief abstract of several new studies on various
supplements and natural medicine topics, including vision enhancement, and their practical
interpretation by Ray Sahelian, M.D.
The common citrus bioflavonoids include:
Apigenin -- found
in high amounts in parsley,
Thyme, and peppermint
and many other herbs including
lemon balm.
Hesperidin --
found in citrus peel and pulp -- commercial orange juice provides 444 mg/l
hesperidin
Hesperitin --
Naringenin
Naringin
Narirutin -- commercial orange juice provides 96 mg narirutin per liter
Nobiletin -- a citrus bioflavonoid isolated from tangerines
Quercetin is found
in high amounts
in onions, kale, hot peppers, and rutabagos.
Rutin
Tangeretin
Tangeritin
Citrus Bioflavonoid Research Update
Hesperidin, a citrus bioflavonoid, inhibits bone loss and decreases
serum and hepatic lipids in ovariectomized mice.
J Nutr. 2003 Jun;133(6):1892-7.
The purpose of this study was to examine whether hesperidin inhibits
bone loss in ovariectomized mice (OVX), an animal model of postmenopausal
osteoporosis. Hesperidin administration did
not affect the uterine weight. These results suggest a possible role for
citrus bioflavonoids in the prevention of lifestyle-related diseases
because of their beneficial effects on bone and lipids.
Biological properties of citrus bioflavonoids pertaining to cancer and
inflammation.
Curr Med Chem. 2001 Feb;8(2):135-53.
Manthey JA, Grohmann K, Guthrie N.
US Citrus and Subtropical Products Laboratory, USDA, ARS, SAA, Winter
Haven, FL
Citrus bioflavonoids encompass a diverse set of structures, including
numerous flavanone and flavone O- and C-glycosides and methoxylated
flavones. Each of these groups of compounds exhibits a number of in vitro
and in vivo anti-inflammatory and anticancer actions. These biological
properties are consistent with their effects on the microvascular
endothelial tissue. Evidence suggests that the biological actions of the
citrus flavonoids are possibly linked to their interactions with key
regulatory enzymes involved in cell activation and receptor binding. The
citrus bioflavonoids show little effect on normal, healthy cells, and thus
typically exhibit remarkably low toxicity in animals. Citrus bioflavonoid extend their influence in vivo through their induction of
hepatic phase I and II enzymes, and through the biological actions of
their metabolites. Evidence clearly indicates to the potential health
promoting properties of these dietary compounds.
Antiproliferative activities of citrus
bioflavonoids against six human cancer cell lines.
J Agric Food Chem. 2002 Oct 9;50(21):5837-43.
Manthey JA, Guthrie N.
U.S. Citrus and Subtropical Products Laboratory, South Atlantic Area,
Agricultural Research Service, U.S. Department of Agriculture, Winter
Haven, Florida
Citrus fruits contain high concentrations of several classes of
phenols, including numerous hydroxycinnamates, flavonoid glycosides, and
polymethoxylated flavones. The latter group of compounds occurs without
glycosidic linkages and has been shown to inhibit the proliferation of a
number of cancer cell lines. This antiproliferative property was further
demonstrated against additional human cancer cell lines, and the
antiproliferative actions of a series of synthetic methoxylated flavones
were also studied. Similar to the naturally occurring compounds, the
synthetic compounds exhibited strong antiproliferative activities. In many
cases the IC(50) values occurred below 10 microm. Other hydroxylated
flavone and flavanone aglycons also exhibited antiproliferative activities
against the cancer cell lines, with the flavones showing greater
activities than the flavanones. Glycosylation of these compounds removed
their activity. The strong antiproliferative activities of the
polymethoxylated flavones suggest that they may have use as anticancer
agents in humans.
Citrus fruits are well known for providing ample
amounts of vitamin C. But they also supply citrus bioflavonoids, substances that
are not required for life but that may improve health. The major
bioflavonoids found in citrus fruits are diosmin, hesperidin, rutin,
naringin, tangeretin, diosmetin, narirutin, neohesperidin, nobiletin, and
quercetin. Citrus bioflavonoids and related substances are widely used in
Europe to treat diseases of the blood vessels and lymph system, including
hemorrhoids, chronic venous insufficiency, leg ulcers, easy bruising,
nosebleeds, and lymphedema following breast cancer surgery. Citrus
bioflavonoids are thought to work by strengthening the walls of blood
vessels.
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