Bioflavonoids are a group of plant pigments that are responsible for the colors of many flowers and fruits. Citrus bioflavonoids are those bioflavonoids, or flavonoids, found in citrus fruits such as lemon, orange, tangerine, grapefruit, etc.

Citrus bioflavonoids possess antioxidant activities, which help fight poor health and aging. Citrus bioflavonoids have been investigated for their biological activity, with both anti-inflammatory and -carcinogenic effects being reported. Flavonoids are a subset of a larger group of beneficial plant substances known as Polyphenols.

Eyesight Rx with Citrus Bioflavonoids
5 sublingual tablets in a foil pack
Supports Healthy Vision
Physician Formulas
Developed by Ray Sahelian, M.D.

Unlike some vision products that provide nutrients and herbs for long term healthy eyesight support, and prevention of visual impairment, but don't seem to have much of an immediate effect on visual acuity, Eyesight Rx was formulated to provide a quick and noticeable eyesight improvement within hours or days of use.

Reports from Eyesight Rx users indicate enhanced clarity of vision, colors being brighter, better focus, and overall improvement in close and distance vision. We've had reports of some people noticing this effect within a half hour, while most people notice improved eyesight within hours. Still others will realize their eyesight is sharper the next morning when they take their second dose.

Supplement Facts:
Serving size: One Third tablet
servings per container: 15

Amount per serving:
Vitamin C - 10 mg - 16% Daily Value
   (Ascorbic acid)

Proprietary Blend 190mg*
Citrus bioflavonoids
     (eriocitrin, hesperidin, flavonols, flavones, flavonoids, naringenin, and quercetin)
Mixed carotenoids
     (alpha carotene, astaxanthin, beta carotene, cryptoxanthin, Lutein, Lycopene, Zeaxanthin)
Bilberry extract (Vaccinium myrtillus)
Eyebright extract (Euphrasia officianales)
Jujube extract (Zizyphus jujube)
Ginkgo biloba (Ginkgo biloba)
Suma extract (Pfaffia paniculata)
Mucuna pruriens extract (Cowhage)
Cinnamon (Cinnamomum zeylanicum)
Lycium berry extract (Lycium Barbarum) also known as Goji Berry
Sarsaparila (Sarsaparilla Smilax)
Alpha Lipoic Acid


Suggested use: Break the tablet with your front teeth and melt a third under your  tongue. Save the rest for another time.

Click Eyesight Rx to order this product or to order Lutein, Carotenoids, and other vision supporting supplements available at Physician Formulas
Subscribe to a FREE Supplement Research Update newsletter  Twice a month we email you a brief abstract of several new studies on various supplements and natural medicine topics, including vision enhancement, and their practical interpretation by Ray Sahelian, M.D.

The common citrus bioflavonoids include:
Apigenin -- found in high amounts in parsley, Thyme, and peppermint and many other herbs including lemon balm.
Hesperidin -- found in citrus peel and pulp -- commercial orange juice provides 444 mg/l hesperidin
Hesperitin --
Naringenin
Naringin
Narirutin -- commercial orange juice provides 96 mg narirutin per liter 
Nobiletin -- a citrus bioflavonoid isolated from tangerines
Quercetin is found in high amounts in onions, kale, hot peppers, and rutabagos.
Rutin
Tangeretin
Tangeritin

Citrus Bioflavonoid Research Update
Hesperidin, a citrus bioflavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice.
J Nutr. 2003 Jun;133(6):1892-7.
The purpose of this study was to examine whether hesperidin inhibits bone loss in ovariectomized mice (OVX), an animal model of postmenopausal osteoporosis. Hesperidin administration did not affect the uterine weight. These results suggest a possible role for citrus bioflavonoids in the prevention of lifestyle-related diseases because of their beneficial effects on bone and lipids.

Biological properties of citrus bioflavonoids pertaining to cancer and inflammation.
Curr Med Chem. 2001 Feb;8(2):135-53.
Manthey JA, Grohmann K, Guthrie N.
US Citrus and Subtropical Products Laboratory, USDA, ARS, SAA, Winter Haven, FL
Citrus bioflavonoids encompass a diverse set of structures, including numerous flavanone and flavone O- and C-glycosides and methoxylated flavones. Each of these groups of compounds exhibits a number of in vitro and in vivo anti-inflammatory and anticancer actions. These biological properties are consistent with their effects on the microvascular endothelial tissue. Evidence suggests that the biological actions of the citrus flavonoids are possibly linked to their interactions with key regulatory enzymes involved in cell activation and receptor binding. The citrus bioflavonoids show little effect on normal, healthy cells, and thus typically exhibit remarkably low toxicity in animals. Citrus bioflavonoid extend their influence in vivo through their induction of hepatic phase I and II enzymes, and through the biological actions of their metabolites. Evidence clearly indicates to the potential health promoting properties of these dietary compounds.

Antiproliferative activities of citrus bioflavonoids against six human cancer cell lines.
J Agric Food Chem. 2002 Oct 9;50(21):5837-43.
Manthey JA, Guthrie N.
U.S. Citrus and Subtropical Products Laboratory, South Atlantic Area, Agricultural Research Service, U.S. Department of Agriculture, Winter Haven, Florida
Citrus fruits contain high concentrations of several classes of phenols, including numerous hydroxycinnamates, flavonoid glycosides, and polymethoxylated flavones. The latter group of compounds occurs without glycosidic linkages and has been shown to inhibit the proliferation of a number of cancer cell lines. This antiproliferative property was further demonstrated against additional human cancer cell lines, and the antiproliferative actions of a series of synthetic methoxylated flavones were also studied. Similar to the naturally occurring compounds, the synthetic compounds exhibited strong antiproliferative activities. In many cases the IC(50) values occurred below 10 microm. Other hydroxylated flavone and flavanone aglycons also exhibited antiproliferative activities against the cancer cell lines, with the flavones showing greater activities than the flavanones. Glycosylation of these compounds removed their activity. The strong antiproliferative activities of the polymethoxylated flavones suggest that they may have use as anticancer agents in humans.

Citrus fruits are well known for providing ample amounts of vitamin C. But they also supply citrus bioflavonoids, substances that are not required for life but that may improve health. The major bioflavonoids found in citrus fruits are diosmin, hesperidin, rutin, naringin, tangeretin, diosmetin, narirutin, neohesperidin, nobiletin, and quercetin. Citrus bioflavonoids and related substances are widely used in Europe to treat diseases of the blood vessels and lymph system, including hemorrhoids, chronic venous insufficiency, leg ulcers, easy bruising, nosebleeds, and lymphedema following breast cancer surgery. Citrus bioflavonoids are thought to work by strengthening the walls of blood vessels.

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