What's in cnidium monnieri herb?
Cnidium seed contains several compounds including coumarins osthol or osthole, xanthotoxol, imperatorin, bergapten, monoterpene polyols, glucides and hepatoprotective sesquiterpenes. Osthole has been found in studies to have anti tumor activity and to be helpful in strengthening bones.
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Dr. Ray Sahelian, M.D. and his research staff have tested various doses and extracts of exotic herbs from a number or raw material suppliers to determine the ideal dose and combination for optimal libido enhancement with fewest side effects. After years of trial and error, a proprietary blend with 11 herbal extracts, has been created which works within hours. This unique blend is a close kept secret known only to Dr. Sahelian and his research staff. You will only find this exact combination in Passion Rx.
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The potent herbal extracts in this sex pill include acetylcarnitine, ashwagandha, catuaba, choline, cnidium, coleus forskohlii, damiana, DMAE, horny goat weed herb, maca herb, mucuna pruriens herb, muira puama herb, passion flower herb, rehmannia herb, rhodiola, shilajit, suma, tribulus, and tongkat ali. A version of Passion Rx has yohimbe.
Benefit, research review
Preliminary studies show some of the compounds in cnidium monnieri may have anti-histamine, anti-itch, anti-fungal, and anti-bacterial effects, along with having an influence on the pituitary-adrenocortex axis.
Studies on rodents indicate that cnidium monnieri may improve bone strength (coumarins from fruits of cnidium monnier inhibit formation and differentiation of multinucleated osteoclasts of rats).
Coumarins from Cnidium monnieri and their
proliferation stimulating activity on osteoblast-like UMR106 cells.
The chloroform fraction from the crude extract was found to have the most stimulating activity. Three coumarins (osthole, bergapten and imperatorin) were isolated, and their effects on osteoblastic proliferation were investigated. Osthole, a major pharmacologically active constituent, significantly promoted the cells' activity. Bergapten and imperatorin were less effective than osthole. These results suggested Cnidium monnieri extracts might have potential activity against osteoporosis, and its chloroform fraction might contain active constituents stimulating osteoblasts.
or erectile dysfunction treatment
In rabbits, a coumarin compound found in cnidium called osthol or osthole was found to help relax the corpus cavernosa of the penis, which would potentially help with blood flow in those with erectile dysfunction.
Vasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus
Planta Med. 2001.
Four known coumarins, osthole, imperatorin, xanthotoxin, and isopimpinellin from the ethanolic extract of the fruit of Cnidium monnieri exhibited relaxing effect In phenylephrine-precontracted endothelium-intact rabbit corpus cavernosum.
Effect of the plant-extract osthole on the relaxation of rabbit corpus cavernosum tissue in vitro. J Urol 2000.
Cancer and anti tumor potential
Cnidium monnier may have anti-cancer properties.
Cytotoxic activity of coumarins from the fruits of Cnidium monnieri on
leukemia cell lines.
Taipei Medical University, Taipei, Taiwan. Planta Med. 2003.
Cnidii monnieri Fructus is used as a tonic agent in traditional Chinese medicine. In a previous Chinese herb-cytotoxicity screening test, the ethanol extract of cnidium monnieri exhibited strong effects on human leukemia (HL-60), cervical carcinoma (HeLa) and colorectal carcinoma (CoLo 205) cells. Then, the cnidium monnieri extract was subjected to silica gel column chromatography and recrystallization to give five coumarins: osthol, imperatorin, bergapten, isopimpinellin, and xanthotoxin. Among these compounds, osthol showed the strongest cytotoxic activity on tumor cell lines. Our results indicate that osthol and imperatorin can induce apoptosis in HL-60 cells.
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Acetyl-l-Carnitine 300 mg - mind
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CoQ10 50 mg - for healthy energy metabolism and heart function
Curcumin the active extract from turmeric, found in curry spice
Tongkat Ali 200 mg - herbal libido enhancer from Malaysia
Mangosteen - contains powerful xanthone antioxidants
Serrapeptase has anti-inflammatory benefits
Cnidium is available in bulk powder, however it is currently not easily found by itself as a supplement. it is most often found in combination with other libido herbs in formulations. Cnidium herb is also available in different extract potencies, for instance a 4 to 1 extract and a 10 to 1 extract. You will also find cnidium extract sold as a 30 percent osthole extract.
Osthole improves aspects of spatial performance in ovariectomized rats.
Am J Chin Med. 2004.
The present study was designed to investigate the ameliorating effects of cnidiuim monnieri L. Cusson and osthole, a constituent of Cnidiuim monnieri, on the spatial performance deficit in scopolamine (SCOP)-treated or ovariectomized (OVA) rats. Cnidiuim monnieri improved the deficit of spatial performance, and reversed the lower plasma estradiol levels caused by SCOP in female rats. We find that osthole is an active constituent of cnidiuim monnieri, and possesses ameliorating effects on the spatial performance deficits in SCOP-treated female rats or OVA rats. The action mechanism of the effects of osthole on performance deficits was related to the estrogen-like properties and activating the central cholinergic neuronal system.
Mechanism of the antiasthmatic effect of
total coumarins in the fruit of Cnidium monnieri Zhongguo
Zhong Yao Za Zhi 1990.
Anti-allergic effects of cnidii monnieri fructus (dried fruits) and its major component, osthol. Biol Pharm Bull. 2002.
Additional articles of interest
Chinese herbs information
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DHEA natural hormone
Ginkgo biloba brain booster
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Melatonin sleep hormone
Saw palmetto herb for prostate
Books written by Dr. Sahelian include those on mental power enhancement and sexual pleasure increase
Q. I did a search for Passion Rx in google and came across a website that was selling Viastat. Can you tell me more about Viastat, is there a review that you have that i can read? I saw that it has cnidium in it.
A. We generally prefer not to comment on other products. We have not tried Viastat so we don't have a review. This sexual product has eurycoma longifolia and cnidium monnieri. These herbs and herbal extracts are legitimate sex herbs, but we don't know if the combination is effective or whether Viastat has side effects or what the appropriate the appropriate dose would be.
I have seen cnidium monnier and monnieri
spellings. Which is right?
The few studies published on this herb that we have seen mention it as monnieri, but we have also seen it spelled as cnidium monnier.
I am interested in taking cnidium herb for the
strengthening of bones, I read in your info that it was helpful. Is there
something else that would be better? Is it good for women or just men? Is it a
blood thinner? Do you offer it by itself? Can it be taken safely along with an
ACE inhibitor for blood pressure?
Hardly any human studies have been done with this plant so it is difficult to answer these questions. There are many other dietary supplements that have been evaluated for bone health and osteoporosis treatment.