Asiatic Cornelian Cherry Fruit -- Corni Fructus
Asiatic Dogwood. Latin name: Cornus officinalis. Other name: Shan Zhu Yu. Asiatic Dogwood is a common remedy in traditional Chinese medicine.
For a list of herbs used in Chinese medicine, see Chinese Herbs.
Cornus Officinalis has been tested in liver cancer.
Rehmannia Endurance, 637 mg, 150
Tabs - With Cornus fruit
Planetary Formulas
Planetary Formulas Rehmannia Endurance is based on the classic Chinese tonifer
Rehmannia Six: Liu Wei Di Huang Wan, one of the most strengthening tonics of
Chinese herbalism. Traditionally it was used for those who are tired and run
down from overwork and inadequate rest due to a fast paced-lifestyle.
Supplement Facts:
Serving Size 1 Tablets
Servings Per Container 150
Amount Per Serving:
Calcium - 128 mg - 15%DV
Rehmannia Root - 320 mg
*
Poria Cocos Sclerotium
- 160 mg *
Tree Peony Root Bark - 160
mg *
Dioscorea Root - 160 mg
*
Alisma Rhizome - 160 mg *
He Shou Wu Root (Fo Ti) - 80
mg *
Chrysanthemum
Flower - 64 mg *
Ligustrum Seed - 64 mg +
Saw Palmetto Berry - 48 mg *
Lycii Fruit Extract - 40 mg
*
Cornus Fruit - 18 mg *
Suggested Use: One tablet daily in the morning, or as
recommended by your health care professional.
* Daily value not established
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Composition of Cornus Officinalis
Cornusiin A, cornusiin B and cornusiin C, cornuside, are dimeric,
monomeric and trimeric hydrolyzable tannins, loganin, morroniside,
Dimethyltetrahydrofuran cis-2,5-dicarboxylate a furan derivative, gallic
acid, 1,2-benzenedicarboxylic acid, butyl 2-methylpropyl ester, isopropyl
myristate, anthocyanins.
Cornus Officinalis Research Update
Chemoprevention against hepatocellular carcinoma of Cornus
officinalis in vitro.
Am J Chin Med. 2004;32(5):717-25.
The water extracts of Cornus officinalis Sieb. et Zuce against
hepatocellular carcinoma (HCC) was studied for its chemopreventive
potential. Three HCC cell lines (HepG2, SK-Hep1 and PLC/PRF/5) and three
leukemic cell lines (U937, K562 and Raji) were tested with XTT assay.
Extracts of C. officinalis inhibited all these HCC cells and leukemic
cells at a concentration of 100 microg/ml (P < 0.05) and was
dose-dependent (P < 0.0001). P53 (P< 0.0001) and Ras significantly
affected its activity against HCC. Extracts of C. officinalis also
possessed the anti-oxidant activity through free radicals scavenging
activity at a concentration of 50 microg/ml (P < 0.05). In summary, our
experiment implied that C. officinalis might be a candidate for
chemopreventive agent against HCC through the antioxidant and anti-neoplastic
effects.
Corni fructus as the major herb of Die-Huang-Wan for lowering plasma
glucose in Wistar rats.
J Pharm Pharmacol. 2004 Nov;56(11):1443-7.
Die-Huang-Wan is a mixture of six herbs used to lower plasma glucose by
increasing insulin secretion in normal rats. Die-Huang-Wan contains the
herbs dioscorea (Dioscoreae rhizoma), cornus (Corni fructus), alisma (Rhizoma
alismatis), holelen (Poria), rehmannia (Rehmanniae radix) and tree peony
bark (Moutan radicis cortex). The present study was designed to clarify
the major herb contributing to the plasma glucose-lowering action of
Die-Huang-Wan in rats. A decrease in plasma glucose was not observed in
Wistar rats treated with the cornus-deleted formula of Die-Huang-Wan;
however, the action was retained in the other herb-deleted formulas
containing cornus. In normal rats, the decrease in plasma glucose and
increase in plasma insulin concentrations were dependent on the dose of
cornus and were similar to those produced by Die-Huang-Wan. Treatment of
Wistar rats with each of the other five herbs separately did not result in
a decrease in plasma glucose. Moreover, the increase in plasma insulin or
reduction in plasma glucose resulting from cornus treatment was blocked by
atropine or 4-diphenylacetoxy-N-methylpiperidine methiodide mustard,
indicating mediation of muscarinic M(3) receptors similar to that caused
by Die-Huang-Wan. These results suggest that cornus is the major
contributor to the plasma glucose-lowering action in Die-Huang-Wan in
normal rats.
[Effect of alcohol extract of Cornus officinalis Sieb. et Zucc on
GLUT4 expression in skeletal muscle in type 2 (non-insulin-dependent)
diabetic mellitus rats]
Zhongguo Zhong Yao Za Zhi. 2001 Dec;26(12):859-62.
Based on its effects of decreasing postprandial plasma glucose and
increasing insulin level in non-insulin-dependent diabetic mellitus (NIDDM)
rats, we studied the effects of Alcohol extract of Cornus officinalis Sieb.
et Zucc on the GLUT4 expression in NIDDM model rats. CONCLUSION: This
experiment demonstrated that alcohol extract of Cornus officinalis Sieb.
et Zucc can increase GLUT4 mRNA and its protein expression in NIDDM rats
through promoting proliferation of islet and increasing postprandial
secretion of insulin and therefore accelerate glucose transport.
Characterization, quantification, and bioactivities of anthocyanins
in Cornus species.
J Agric Food Chem. 2002 Apr 24;50(9):2519-23.
Seeram NP, Schutzki R, Chandra A, Nair MG. Bioactive Natural Products and
Phytoceuticals, Department of Horticulture and National Food Safety,
Michigan State University, East Lansing, MI
Cornus mas, Cornus officinalis, Cornus controversa, and Cornus kousa (Cornaceae)
bear edible fruits that are consumed in parts of Europe and Asia. This
study undertook the investigation of the presence and levels of
anthocyanins in the fruits of these Cornus species by HPLC. The
anthocyanins present in Cornelian cherries, C. mas, are delphinidin
3-O-beta-galactopyranoside (1), cyanidin 3-O-beta-galactopyranoside (2),
and pelargonidin 3-O-beta-galactopyranoside (3). C. officinalis contains
only anthocyanins 1-3, similar to C. mas, but in different proportions.
However, C. controversa contains anthocyanins 1-3 among other anthocyanins,
but Chinese dogwood, C. kousa, did not contain 1-3. The contents of pure
anthocyanins 1, 2, and 3 in 1 kg of fresh fruits of C. mas, C. officinalis,
and C. controversa were 280, 1079, and 710 ppm; 11, 77, and 230 ppm; and
600, 1000, and 700 ppm, respectively. In cyclooxygenase (COX)-I and -II
enzyme inhibitory assays, anthocyanins 1-3 (all 40 microM) showed
activities of 9.2 and 11.7%; 7.6 and 12.4%; and 5.3 and 7.8%,
respectively, compared to Naproxen (54.3 and 41.3%; 10 microM), ibuprofen
(47.5 and 39.8%; 10 microM), Celebrex (46.2 and 66.3%; 1.67 ppm), and
Vioxx (23.8 and 88.1%, 1.67 ppm). In the antioxidant assay, anthocyanins
1-3 (all 40 microM) showed activities of 70.2, 60.1, and 40.3%,
respectively. At 10 microM concentration, commercial synthetic
antioxidants tert-butylhydroquinone, butylated hydroxytoluene, butylated
hydroxyanisole, and vitamin E gave 83.2, 79.7, 82.1, and 10.2% of
antioxidant activity, respectively.
A substance isolated from Cornus officinalis enhances the motility
of human sperm.
Am J Chin Med. 1997;25(3-4):301-6.
The effects of a Chinese herb, Cornus officinalis, on the motility of
human sperm was studied. An aqueous extract was prepared from the dried
fruits of the herb and used in this study.