Other Names : CAD, Coronary Heart Disease (CHD), Heart Disease, Ischemic Heart Disease.
Coronary heart disease is one of the most serious
medical conditions in the United States and stable angina pectoris is one of its
more common presentations. Three major controversies are risk factor management,
drug therapy, and intervention. As well as the major risk factors stated by the
Framingham study and European guidelines, other factors include abdominal
obesity, metabolic syndrome, and psychological stress.
Drug therapy for Coronary Artery Disease
Apart from aspirin, many patients with stable angina are considered by
the medical establishment to start statin treatment. Although statins may reduce
coronary events by about one third in patients with vascular disease, the
absolute benefit depends on the absolute risk. Many patients may benefit from
natural lifestyle changes or natural supplements.
Some patients may benefit from angiotensin-converting-enzyme
inhibitors. The concept that beta blockers are protective from future coronary
events is disputed.
Natural Supplements for Those
with Coronary Artery Disease
It's a good idea to take a daily
multivitamin and
mineral capsule that provides the RDA for the B vitamins with additional
antioxidants such as Vitamins C and E. Very high doses of multivitamins are not
recommended.
Surgical Options for Coronary
Artery Disease
Percutaneous coronary intervention can relieve symptoms without extending
lifespan beyond medical therapy. However, strong mortality data favor
coronary-artery bypass grafting in individuals with triple-vessel or even
double-vessel disease. Thus, effort angina needs comprehensive assessment,
lifestyle changes, and treatment tailored to the individual patient.
Coronary Artery
Disease and Mental Stress
Patients with coronary artery disease
(CAD) who have normal exercise- or adenosine-induced stress test results may
still develop perfusion deficits when under mental stress. There have been
reports of mental stress causing ischemia in CAD patients with exercise-induced
ischemia. Positive exercise stress tests are related to major narrowing of
epicardial coronary arteries. During mental stress, patients experience a spasm
or decreased blood flow in the smaller vessels related to endothelial
dysfunction.
Periodontitis and
Coronary Artery Disease
Patients with periodontitis, especially infections causing a high concentration
of pathogens in the blood, have an increased risk of coronary heart disease.
Chronic inflammation from any source iincreases cardiovascular risk and
periodontitis is a possible trigger of chronic inflammation. Pathogens that
cause periodontal disease may include the following: Actinobacillus
actinomycetemcomitans, Tannerella forsythensis, Porphyromonas gingivalis,
Prevotella intermedia, and Treponema denticola. There is a significant
association between high levels of periodontal pathogen and the presence of
coronary artery disease. High levels of A. actinomycetemcomitans antibodies also
predict an increased risk of stroke. The Archives of Internal Medicine, March
13, 2006.
Coronary artery
disease diagnosis
Stress cardiac magnetic resonance imaging (MRI) "demonstrates overall good
sensitivity and specificity for the diagnosis of coronary artery disease.
Racial Differences
in Coronary Artery Disease
Racial and ethnic minorities in the United States have a risk for
coronary artery disease equivalent to that in the white majority. African
Americans have greater cardiovascular mortality rates and greater risk for early
mortality caused by coronary artery disease. Risk may be associated with a
greater clustering of risk factors in African Americans and other minority
groups and may be associated with inadequate screening and evidence-based
treatment of these groups in clinical practice. African Americans have a higher
level of the inflammatory marker high-sensitivity C-reactive protein than
whites.
Coronary artery disease is a type of
atherosclerosis in which plaque builds up inside the arteries that carry blood
to the heart. As the artery walls thicken, the passageway for blood narrows.
Sometimes platelets gather at the narrowing, forming a clot that decreases or
prevents blood flow to the region of the heart supplied by the artery. Coronary
artery disease is the leading cause of death for both men and women in the
United States each year.