Daflon supplement benefit and side effects by Ray Sahelian, M.D.

Daflon is an oral medicine used in the treatment of venous disease, ie, chronic venous disease and hemorrhoids. It is a micronized purified flavonoid fraction containing 90% diosmin and 10% flavonoids expressed as Hesperidin.

Daflon for venous leg ulcer
Angiology. 2005. Department of Surgery, UCL Medical School, The Middlesex Hospital, London, UK. Daflon 500 mg and venous leg ulcer: new results from a meta-analysis.
The objective of this study was to assess the effect of oral treatment with Daflon 500 mg (micronized purified flavonoid fraction [MPFF]) on leg ulcer healing. This study was conducte. Five prospective, randomized, controlled studies in which 723 patients with venous ulcers were treated between 1996 and 2001 were identified. Conventional treatment (compression and local care) in addition to Daflon 500 mg 2 tablets daily was compared with conventional treatment plus placebo in two studies (n = 309), or with conventional treatment alone in three studies (n = 414). These results confirm that venous ulcer healing is accelerated by Daflon 500 mg treatment. Daflon 500 mg might be a useful adjunct to conventional therapy in large and longstanding ulcers that might be expected to heal slowly.

Daflon for hemorrhoids
Daflon for hemorrhoids: a prospective, multi-centre observational study.
Surgeon. 2004. Department of Surgery, Dammam Central Hospital, Dammam, Eastern Province, Saudi Arabia.
Daflon, a phlebotropic agent, is of proven efficacy in the treatment of various venous disorders. Although it has been tried in the treatment of hemorrhoids, its efficacy in alleviating various symptoms of hemorrhoid has not been assessed properly. The aim of this study was to confirm the efficacy of Daflon in the treatment of such symptoms. Two hundred and sixty eight patients presenting with hemorrhoids were recruited. After establishing the extent of their symptoms and determining the position, size and degree of haemorrhoids by proctoscopy, all patients were started on Daflon, four tablets per day, in two divided doses for four weeks. Patients were seen weekly during the study period and carefully questioned as regard to symptoms, and a proctoscopy was carried out. There was a statistically significant improvement in all haemorrhoidal symptoms (pain, heaviness, bleeding, pruritus and anal discharge) and in the proctoscopic appearance of the 'piles,' comparing baseline visit findings with the last visit four weeks after treatment with Daflon. Daflon has been shown to be effective in alleviating (variable degree) haemorrhoidal symptoms and improving the proctoscopic appearance of hemorrhoids. Therefore, it should be considered initially for patients presenting with haemorrhoidal symptoms.

Daflon side effects, safety issues
Q. From couple of days I am taking Daflon 500mg (two tablets daily) for pre-anal hematoma or hemorrhoid. I am feeling headache, nausea. I wanted to know whether the above side effects are due to the medication or some other reason?
   A. I have not used Daflon in my practice yet and do not know the answer at this time but I will keep my eyes open for new research. You may wish to stop this supplement for a few days and restart with one tablet to see if the symptoms occur. Let us know how it goes and if the side effects occur with one Daflon tablet.

Emails
Hello, I'm from Florida USA. I'm looking for a medicine called Daflon. I been looking everywhere here in Florida but no one knows that medicine.
   Hi, we are not aware of it being sold in the US, but we have not looked extensively.

My mother lives in Tehran, she is 87 years old, but in good health, except she is in pain with hemorrhoids. She has been trying to locate the medicine but she has not been successful. Where this drug is made? If it is in Europe, I have friends there, which can purchase and send to her. Or can I place order with a company in Europe and have them send it to her?
   A google search reveals a company called Jandrugs dot com carries this product.