Diosmin by Ray Sahelian, M.D.

Diosmin is a flavonoid that can be isolated from various plant sources or derived from the flavonoid hesperidin. Diosmin was first introduced used in medical treatment in 1969. Diosmin is useful in chronic venous insufficiency, hemorrhoids, lymphedema, and varicose veins. Diosmin also has anti-inflammatory, antioxidant, and anti-cancer properties.

Diosmin and lung cancer
The effect of the flavonoid diosmin, grape seed extract and red wine on the pulmonary metastatic B16F10 melanoma.
Histol Histopathol. 2005 Oct;20(4):1121-9. Pathology Department, Faculty of Medicine, University of Murcia, Espinardo, Spain.
To study the effect of different phenolic compounds and red wine on pulmonary metastatic melanoma. Swiss mice were inoculated with 500000 melanocytes B16F10 and given oral doses of diosmin, grape seed extract (GSE) and red wine. A macroscopic count was made of the metastatic nodules on the lung surface and a microscopic study by image analysis of five sections, calculating the implantation percentage and tumoral growth and invasion indices.  Macroscopically, the group treated with diosmin showed the greatest reduction (52%) in the number of metastatic nodules compared with the control group, which was treated with ethanol, while GSE and red wine caused decreases of 26 and 28%, respectively. Microscopically, there was a decrease in the implantation percentage after the administration of diosmin (79%) and red wine (20%), and an increase of 2% after the administration of GSE, all relative to the ethanol-treated control. As regards the growth index, diosmin produced a reduction of 67% and red wine a reduction of 20%, while GSE again produced an increase (25%). Diosmin originated the greatest reduction in pulmonary metastases, both at the macroscopic and microscopic levels.

Treatment of metastatic melanoma B16F10 by the flavonoids tangeretin, rutin, and diosmin.
J Agric Food Chem. 2005 Aug 24;53(17):6791-7. Pathology Department, Faculty of Medicine, University of Murcia, 30100 Espinardo, Murcia, Spain.
Melanoma is one of the most frequently metastasizing malignant neoplasias. This study examines an experimental model of pulmonary metastasis and the B16F10 cell subline, highly metastatic in the lung. Antimetastatic effects of the flavonoids tangeretin, rutin, and diosmin were analyzed, and at the same time an analysis of the metastatic activity of ethanol was performed, considered to be necessary because it is used as a vehicle for administering the flavonoids.  The greatest reduction in the number of metastatic nodules (52%) was obtained with diosmin. Rutin- and tangeretin-treated groups also showed reductions of the same index compared with the ethanol group. It would seem that structural factors would better explain these results and the antimetastatic activity of each flavonoid and the respective metabolites.

Diosmin in Daflon and product DiosVein - press release by Berg imports
There appears to be improvement in microcirculatory disorders experienced by diabetic patients that were treated with Daflon 500mg -a fraction flavonoid, 90% of which is comprised of the supplement Diosmin. Derived from Sweet Orange, Diosmin is the predominant component of the ingredient DiosVein, used for over 30 years as an anti-inflammatory and vascular-protecting agent. A study conducted in France by a research team lead by A. Behar, M.D., treated thirteen diabetic outpatients who had been suffering from a microcirculatory condition anywhere from one to nineteen years and who had abnormal albumin retention. Each study participant took two tablets daily of Daflon 500 mg for the duration of one month. Any treatments that were already in place prior to participation were continued during the study. A test was performed before and at the end of the study to measure albumin retention in the urine. Twelve of the thirteen patients experienced normalization in the levels of albumin. In 10 out of 13 patients, the test was carried out a third time several months after the Daflon 500mg treatment was withdrawn. For patients who had albumin normalization during treatment, results were again abnormal. In a different study, also conducted by Behar, a placebo-controlled trial lasting 30 to 42 days included two equal groups of 20 diabetic patients - one group treated with the flavonoid fraction and one being a placebo group. At the end of treatment, albumin retention significantly decreased in the group treated with the flavonoid fraction in contrast with the placebo group. In 65% of the flavonoid patients, albumin levels normalized, compared to only 25% of patients in the placebo group. This study, along with others testing the flavonoid fraction Daflon 500mg, suggest that this treatment can improve and even normalize capillary filtration of albumin in diabetic patients. DiosVein, made from the supplement Diosmin, provides soothing relief of vein discomfort and rarely interferes with other doctor-prescribed therapies. Recommended by doctors in Europe as an efficacious, natural option, DiosVein has been clinically shown to be effective in strengthening veins and aiding in circulation health. The DiosVein brand of Diosmin has been launched into the U.S. supplement and nutraceutical market. Exclusively available through Berg Imports LLC

Diasmin emails.
Q. Thank you so very much for you report on Diosmin and Hesperidin. I will continue to read your website. I found you via MSN search engine.