Erythorbic acid is a stereoisomer of ascorbic acid with similar properties. It is widely used as an antioxidant in processed foods.
Erythorbic Acid studies
Erythorbic acid is a potent enhancer of nonheme-iron absorption.
Am J Clin Nutr. 2004.
Institute of Food Science and Nutrition, Swiss Federal Institute of Technology,
Zurich, Rueschlikon, Switzerland.
The aims of the present study were to evaluate the effect of erythorbic acid on
iron absorption from ferrous sulfate at molar ratios of 2:1 and 4:1 (relative to
iron) and to compare the effect of erythorbic acid directly with that of
ascorbic acid at a molar ratio of 4:1. Iron absorption from
iron-fortified cereal was measured in 10 women on the basis of erythrocyte
incorporation of stable iron isotopes ((57)Fe or (58)Fe) 14 d after
administration. Each woman consumed 4 ferrous-sulfate-fortified test meals
(containing 5 mg Fe/meal) with or without added erythorbic or ascorbic acid. The
data were evaluated by use of paired t tests, and the results are presented as
geometric means. Iron absorption from the test meal without any added
enhancer was 4%. The addition of erythorbic acid (at molar ratios of 2:1 and
4:1 relative to iron) increased iron absorption 2.6-fold and
4.6-fold, respectively. The addition of ascorbic acid (molar
ratio of 4:1) increased iron absorption 2.9-fold. At a molar
ratio of 4:1, erythorbic acid was 1.6-fold as potent an enhancer of
iron absorption as was ascorbic acid. Although erythorbic acid is a
potent enhancer of iron absorption, its lack of antiscorbutic activity limits
its usefulness in iron-fortification programs. However, it may play a major role
in enhancing iron bioavailability from mixed diets that include foods preserved
with erythorbic acid.
Effect of smoking on erythorbic acid pharmacokinetics.
Br J Nutr. 2003.
Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural
University, Copenhagen, Denmark.
Smoking significantly lowers the concentration
of plasma antioxidants. Acorbic acid has recently been shown
to be depleted by smoking per se. However, the direct cause of ascorbate
depletion remains unclear. Erythorbic acid is a stereoisomer of ascorbic acid
commonly used as antioxidant in foodstuffs and has the same redox properties as
ascorbic acid. We therefore investigated if erythorbic acid could be used as a
non-isotopic marker of smoking-induced oxidative stress. In a sample of smokers
(n 10) and non-smokers (n 10), the pharmacokinetics of erythorbic acid were
followed after a single oral dose (1 g) and subsequently, the effect of a 2-week
ascorbic acid supplementation (0.5 g/d) on erythorbic acid kinetics was studied
in a double-blind, placebo-controlled fashion. Our present results do not suggest that altered
pharmacokinetics is likely to play a major role in the ascorbic acid depletion
consistently observed in smokers.