Eugenol uses, from clove oil by Ray Sahelian, M.D.
Eugenol is a clear to pale yellow oily liquid extracted from certain essential oils especially from clove oil, nutmeg, cinnamon, and bay leaf. Eugenol has a pleasant, spicy, clove-like aroma.
Eugenol as analgesic in dentistry
Eugenol, a natural congener of capsaicin, is a routine analgesic agent in
dentistry. Eugenol is a major component of root canal sealers and retrograde
filling materials. Zinc-oxide powder mixed with eugenol or cariofillorum oil and
sterilized cotton is frequently used in dental practice as surgical bandage for
eliminating or dry socket. Osteonecrosis of alveolar bone caused by free eugenol
is rare but a possible complication.
Eugenol inhibits the antimicrobial functions of neutrophils.
J Endod. 2008.
Eugenol containing restorative materials are commonly used for vital pulp
therapy. A well-regulated host defense response is pivotal for the success of
vital pulp therapy. The present study was to assess the effects of eugenol on
the antimicrobial functions of polymorphonuclear leukocytes (neutrophils). Treatment
for 30 minutes did not significantly affect
the viability of neutrophils. However, preincubation of neutrophils with eugenol abolished their bactericidal activity against oral
pathogens Streptococcus mutans and Actinobacillus actinomycetemcomitans. In
addition, through the suppression of the extracellular release of
myeloperoxidase and the intracellular production of reactive oxygen species,
eugenol at sufficient concentrations impaired the activation of neutrophils by
cytochalasin B and fMet-Leu-Phe. These results suggested that the antimicrobial
functions of neutrophils were interfered by eugenol, and the inhibitory effects
of eugenol were not due to direct killing of neutrophils.