Eurycoma Longifolia extract supplement side effects, benefit, dosage, review of human studies, does it influence testosterone?
Aphrodisiac benefit, is it safe? Dosage of extract in 25 mg, 50, 70, 100 mg. Full spectrum powder 200 mg.
March 14 2014 by Ray Sahelian, M.D.


Eurycoma longifolia jack is a small tree found in the jungles throughout Malaysia and Southeast Asia. It is commonly known as Tongkat Ali in Malaysia and Singapore, Piak or Tung Saw in Thailand, and Pasak Bumi in Indonesia. The tree can grow up to about 12 meters in height. Natives consider every part of the tree as medicine. Traditionally eurycoma is used as a tonic, to treat malaria, and as an aphrodisiac.

Availability in stores and online, dosage and dose
Eurycoma longifolia is sold as a powder and in capsules, sometimes mixed with other herbs. There are a number of eurycoma longifolia extracts and full spectrum powders available in various potencies, and since each company will have a different way of extracting, it is difficult to give dosage recommendations that would be consistently effective.

Tongkat Ali root powder 200 mg per capsule dosage
buy Eurycoma longifolia extract
- high quality and standardized. It is used for improving energy, increasing stamina, physical endurance, and sensual performance.
Passion Rx potent aphrodisiac formula, developed by Dr. Ray Sahelian, M.D.

Eurycoma longifolia grows wild in the rainforests of the Southeast Asia. In Indo-China. In Malaysia, it is known for its energy, tonic, and sensual vitality properties. Traditionally this root is used to improve energy, reduce fatigue and enhance overall physical and sensual performance. This product is pure raw material directly from Malaysia. The medicinal benefits of eurycoma are found primarily in the root. Physician Formulas eurycoma powder uses only the highest quality Malaysian root aged seven years or more. All root is wild crafted and sterilized.

 

 

Buy Eurycoma longifolia extract supplement, Passion Rx sexual enhancing formula, other sex improving herbs
The potent herbal extracts in Passion Rx formula include Ashwagandha, Catuaba, Cnidium, Damiana, Eurycoma longifolia extract, horny goat weed, Maca, Mucuna pruriens, Muira puama, Passion flower, Rehmannia, Rhodiola, Tribulus, and Yohimbe. This aphrodisiac formula does not have ginseng or ginkgo biloba.

Note: Passion Rx and eurycoma longifolia extract supplements are best taken on separate days since taking them together may cause overstimulation and insomnia.

Suggested Use: As a dietary supplement, take a eurycoma supplement capsule in the morning before breakfast or as recommended by your health care provider. For long term use, take 2 days on, 2 or more days off or take every other day or every third day. Results may vary depending on age and metabolism. Some may require half a capsule while others may do better with two. It may be preferable to take lower doses of eurycoma supplements and have it work slowly in order to avoid the side effects mentioned below. The effects from this bark extract can sometimes last into the next day or even the third day.

Eurycoma longifolia side effects, danger, safety, risk
I have read articles in health magazines that eurycoma supplements provide wonderful sexual benefits with no side effects. This is not my experience. Even though it is useful as an herbal aphrodisiac, it does have shortcomings. One of the side effects of high dose eurycoma root is that it can cause insomnia. Lack of adequate sleep, when repeated over many days, can lower sex drive. So, it's better to take smaller amounts over several days rather than a very high amount for one or two days.
   I have personally tested various extracts in different doses and realized that it has additional side effects not often mentioned in articles or in research papers. Many of my friends and patients have given me feedback regarding their personal experiences with eurycoma supplements. I am convinced that high doses can cause increased body temperature, which is not a good thing during hot and steamy days without air conditioning, but a good thing if you live in Alaska or enjoy taking a walk outside in cool weather. Some people find that when they take a high dose they become restless and impatient, perhaps easily angered. Therefore, you don't want to swallow several capsules of eurycoma pills if you expect to be driving in heavy traffic. So, be patient and take lower doses.

I don't think this herb is useful for bodybuilding purposes.

Eurycoma research as an aphrodisiac, human studies
Evid Based Complement Alternat Med. 2014. Effects of a Proprietary Freeze-Dried Water Extract of Eurycoma longifolia Physta and Polygonum minus on Sexual Performance and Well-Being in Men: A Randomized, Double-Blind, Placebo-Controlled Study. Physta is a proprietary product containing a freeze-dried water extract of Eurycoma longifolia which is traditionally used as an energy enhancer and aphrodisiac. We aim to evaluate a 300 mg combination of Physta and Polygonum minus, an antioxidant, with regard to sexual performance and well-being in men. Men aged 40-65 years were screened for this 12-week randomized, double-blind, placebo-controlled, parallel-group study. Outcome measures included validated questionnaires that aimed to evaluate erectile function, satisfaction with intervention, sexual intercourse performance, erectile hardness, mood, and overall quality of life. Significant improvements were noted in scores for the Sexual Intercourse Attempt diary, Erection Hardness Scale, Sexual Health Inventory of Men, and Aging Male Symptom scale. Laboratory evaluations, including liver and kidney function testing, showed no clinically significant abnormality. Supplementation for twelve weeks with Polygonum minus and the proprietary Eurycoma longifolia extract, Physta, was well tolerated and more effective than placebo in enhancing sexual performance in healthy volunteers.

J Sex Med. 2011. 9-Hydroxycanthin-6-One Induces Penile Erection and Delays Ejaculation. National Research Institute of Chinese Medicine, Taipei, Taiwan. Eurycoma longifolia Jack has the reputation as a male aphrodisiac because it is claimed to increase virility and sexual prowess. Nevertheless, whether or not E. longifolia regulates directly the muscle tone of corpus cavernosa and/or seminal vesicle (SV) remains unclear. Even until now, the compositions that could account for its aphrodisiac property are still unknown. We examined the effect of 9-hydroxycanthin-6-one (9-HC-6-one), a β-carboline alkaloid isolated from E. longifolia, on penile erection and ejaculation, and further elucidated the mechanism of action. 9-HC-6-one relaxed significantly phenylephrine precontracted corpus cavernosim. Such response was not attenuated by endothelium disruption, suggesting that a nitric oxide/cyclic guanosine monophosphate-dependent pathway was precluded. 9-HC-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as well as SV.

Sexual arousal in sexually sluggish old male rats after oral administration of eurycoma longifolia Jack.
J Basic Clin Physiol Pharmacol. 2004. Ang HH, Lee KL. School of Pharmaceutical Sciences, University Science Malaysia, Minden, Penang, Malaysia.
Eurycoma longifolia Jack commonly known as Tongkat Ali in Malaysia, has been used in Malaysia to increase male virility and sexual prowess. The aphrodisiac effect was monitored by the act of yawning and stretching because yawning, either alone or associated with stretching, is considered an ancestral vestige surviving throughout evolution that promotes sexual arousal. The results showed that 800 mg/kg of eurycoma longifolia increased yawning and stretching,

Eurycoma longifolia Jack enhances sexual motivation in middle-aged male mice.
J Basic Clin Physiol Pharmacol. 2003. Ang HH, Lee KL. University Science Malaysia, Minden, Penang, Malaysia.
Each mouse received 500 mg/kg of one of 4 fractions of Eurycoma longifolia Jack, viz. chloroform, methanol, butanol, and water, whereas the mice in the control and yohimbine groups received 3 ml/kg of normal saline and 30 mg/kg of yohimbine daily respectively for 10 days. The results show a transient increase in the percentage of male mice responding to the right choice after chronic consumption of the fractions with 50 percent of the adult middle-aged male mice treated with eurycoma longifolia and yohimbine scoring the right choice after 8 and 5 days post-treatment respectively. This study has shown that eurycoma longifolia continues to enhance sexual motivation in adult, middle-aged male mice and in retired breeders.

Effects of Eurycoma longifolia Jack on sexual qualities in middle aged male rats.
Phytomedicine. 2003.
Our study shows that it enhanced the sexual qualities of the middle aged male rats, further supports the folk use of eurycoma longifolia as an aphrodisiac.

Effect of Eurycoma longifolia Jack on orientation activities in middle-aged male rats.
Fundam Clin Pharmacol. 2002.
Results showed that subjects treated with 800 mg/kg of eurcyoma longifolia Jack increased orientation activities towards the receptive females (anogenital sniffing, licking and mounting), increased genital grooming towards themselves and restricted movements to a particular area of the cage but decreased interest in the external environment (climbing, raring, exploration) as compared with the controls during the investigation period. In conclusion, this study gives further evidences that different fractions modified the orientation activities of the middle-aged male rats.

Effects of Eurycoma longifolia jack on laevator ani muscle in both uncastrated and testosterone-stimulated castrated intact male rats.
Arch Pharm Res. 2001. University Science Malaysia, Minden, Penang, Malaysia.
It has been reported that eurycoma longifolia commonly known as Tongkat Ali has gained notoriety as a symbol of man's ego and strength by the Malaysian men because it increases male virility and sexual prowess during sexual activities. As such, the effects of 200, 400 and 800 mg/kg of butanol, methanol, water and chloroform fractions were studied on the laevator ani muscle in both uncastrated and testosterone-stimulated castrated intact male rats after dosing them for 12 consecutive weeks. Results showed that 800 mg/kg of butanol, methanol, water and chloroform fractions of eurycoma longifolia significantly increased the leavator ani muscle when compared with the control (untreated) in the uncastrated intact male rats and when compared to control (untreated) in the testosterone-stimulated castrated intact male rats. Hence, the pro-androgenic effect as shown by this study further supported the traditional use of eurycoma longifolia as an aphrodisiac.

Mechanism of action, how it works
Little is known regarding the mechanisms of action of eurycoma longifolia. Recent studies indicate that the root contains several compounds including beta-carboline alkaloids and quassinoid-type glycosides. How these compounds and many others in eurycoma influence the human sexual response is not clearly understood. I have read promotional material by some vitamin companies regarding eurycoma that it enhances testosterone production, however I have not been able to definitively confirm this claim through a Medline search.

Cancer influence
Eurycoma longifolia and cancer
Induction of apoptosis by Eurycoma longifolia jack extracts.
Anticancer Res. 2005.
Extracts of the plant eurycoma longifolia have been shown to possess cytotoxic, antimalarial, anti-ulcer, antipyretic and plant growth inhibition activities. The present study investigated the effects of extracts and their chromatographic fractions on the growth of a human breast cancer cell line, MCF-7. These results, therefore, suggest that eurycoma has antiproliferative effects on MCF-7 cells by inducing apoptosis through the modulation of Bcl-2 protein levels.

Osteoporosis
BMC Complement Altern Med. 2012. Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen- deficient osteoporosis rat model. Supplementation with EL extract elevated the testosterone levels, reduced the bone resorption marker and upregulated OPG gene expression of the orchidectomised rats. These actions may be responsible for the protective effects of EL extract against bone resorption due to androgen deficiency.

Sperm production
The standardised extract of TA and its major quassinoids especially eurycomanone improved the rat spermatogenesis by affecting the hypothalamic-pituitary-gonadal axis and the potential efficacy may be worthy of further investigation. J Ethnopharmacol. 2013. Standardized quassinoid-rich Eurycoma longifolia extract improved spermatogenesis and fertility in male rats via the hypothalamic-pituitary-gonadal axis.

Emails
Q. I've tried a eurycoma longifolia product I recently bought from a health food store and even though it helped with erections the next day, I couldn't sleep all night. Is there a way I can still get the pro-sexual benefits of this herb and not toss and turn all night.
   A. You don't mention the product you bought or the dosage, but a general suggestion would be next time to take a quarter of the capsule or pill, and then gradually increase the dose subsequent days till you find the amount that helps without causing the insomnia.

Q. Can eurycoma longifolia be combined with other herbs such as yohimbe or horny goat weed?
   A. I can only speak from my personal and professional experience. Thus far I have combined it with several herbs and have found that when high doses are taken with other herbs that have stimulating properties, such as ginseng or muira puama, there is the potential for insomnia.

Q. Does eurycoma longifolia give more energy?
   A. This plant is a powerful energy booster. I find that after 2 or 3 days of taking it, there is a general sense of enhanced energy that occurs. However, if I take a high dose of eurycoma longifolia, the resulting shallow sleep from the overstimulation can lower my energy levels. I also find that high doses of this herb make me feel restless. For instance, I find that I am less patient and more irritable, particularly if I have taken eurycoma longifolia supplement in the morning and I am stuck in traffic.

Q. Can I take eurycoma longifolia regularly for many months?
   A. As with most herbs, I recommend taking breaks from use. You could take it for 2 or 3 days and take a few days off.

Q. Would you say eurycoma supplement is the best sexual aphrodisiac?
   A. Each herb has its benefits and side effects. I prefer an intelligent mix of several herbs in order to benefit from the various herbs that have affects on different parts of the human sexual response.