Fucose sugar, source, use as
supplement, safety, side effects, benefit for health
August 16 2015 by Ray Sahelian, M.D.
Fucose is a disacharide sugar found on glycans on the mammalian, insect and plant cell surfaces. Fucose is the fundamental sub-unit of the fucoidan polysaccharide. Fucose is covalently attached to glycoproteins at the cell surface.
Effect of a preparation containing a fucose rich polysaccharide on
periorbital wrinkles of human voluntaries.
Skin Res Technol. 2005. Robert C, Robert AM, Robert L. Laboratoire Universitaire de Recherche en Ophtalmologie. Universite Pierre et Marie Curie (Paris 6), Faculte de Medecine Broussais-Hôtel Dieu., Paris cedex 04, France.
We tested the effect of a preparation with fucose rich oligo- and polysaccharide (FROP-3) on periorbital wrinkles (crow's feet) on a team of voluntaries. The efficiency of a preparation containing as active principle a fucose rich polysaccharide in a base-cream for the treatment of temporal periorbital wrinkles on 20 voluntary women was tested as follows: the women applied the cream twice a day for 4 weeks. After 4 weeks of treatment, there was a significant improvement of the periorbital wrinkles for the majority of the voluntary team who tested the cream. Under the effect of 4 weeks of treatment with the FROP-3-containing cream, most of the voluntaries had their periorbital wrinkles attenuated and some women showed a total regression of crow's feet on one of their eyes.
Fucose levels in sera and in tumours of colorectal adenocarcinoma patients.
Cancer Lett. 1997 . Fernández-Rodríguez J, Páez de la Cadena M, Martínez-Zorzano VS. Department of Biochemistry, Genetics and Immunology, University of Vigo, Spain.
Fucose levels were determined in normal and tumor-derived tissues from patients with colorectal adenocarcinoma. Total, free and bound fucose were significantly higher in the tumoral tissue. Comparison of serum fucose levels between patients with colorectal cancer and control subjects indicated no statistically significant differences in total, free and bound fucose expressed as nmol/ml serum. However, when total and bound fucose were normalized to total protein (nmol/mg protein), an elevation in both parameters was found in colorectal cancer patients, although only that for total fucose was statistically significant. A clear association between fucose content and clinical stage of patients according to the Dukes' classification can not be established, although patients at stage C showed higher levels of fucose both in serum and tissue. The current investigation provides direct evidence of a relationship between the elevation of fucose and the presence of tumor in colorectal cancer patients.
Fucose concentrations in sera from patients with rheumatoid arthritis.
Clin Exp Rheumatol. 1995. Kamel M. Dr. Fakhry Hospital, Dhahran, Saudi Arabia.
The clinical significance of L-fucose was investigated in serum of a well characterized cohort of 135 rheumatoid arthritis patients and 60 healthy controls. In rheumatoid arthritis patients, serum L-fucose was significantly decreased. Our findings suggest that serum L-fucose is depressed in patients with rheumatoid arthritis, a promising observation since L-fucose is a safe and simple natural sugar. It may be used as an additional parameter and as an indicator for the disease activity in the follow up of patients with rheumatoid arthritis.
Am J Physiol Lung Cell Mol Physiol. 2013 Sep. Sugar administration is an effective adjunctive therapy in the treatment of Pseudomonas aeruginosa pneumonia. Treatment of acute and chronic pulmonary infections caused by opportunistic pathogen Pseudomonas aeruginosa is limited by the increasing frequency of multidrug bacterial resistance. Here, we describe a novel adjunctive therapy in which administration of a mix of simple sugars-mannose, fucose, and galactose-inhibits bacterial attachment, limits lung damage, and potentiates conventional antibiotic therapy. The sugar mixture inhibits adhesion of nonmucoid and mucoid P. aeruginosa strains to bronchial epithelial cells in vitro. In a murine model of acute pneumonia, treatment with the sugar mixture alone diminishes lung damage, bacterial dissemination to the subpleural alveoli, and neutrophil- and IL-8-driven inflammatory responses. Remarkably, the sugars act synergistically with anti-Pseudomonas antibiotics, including β-lactams and quinolones, to further reduce bacterial lung colonization and damage. To probe the mechanism, we examined the effects of sugars in the presence or absence of antibiotics during growth in liquid culture and in an ex vivo infection model utilizing freshly dissected mouse tracheas and lungs. We demonstrate that the sugar mixture induces rapid but reversible formation of bacterial clusters that exhibited enhanced susceptibility to antibiotics compared with individual bacteria. Our findings reveal that sugar inhalation, an inexpensive and safe therapeutic, could be used in combination with conventional antibiotic therapy to more effectively treat P. aeruginosa lung infections.