health benefit, medical uses, for cancer
August 20 2017 by Ray Sahelian, M.D.
Galangin is present in high concentrations in medicinal plants (e.g. Alpinia officinarum) and propolis, a natural beehive product. Results from in vitro and in vivo studies indicate that galangin with anti-oxidative and free radical scavenging activities is capable of modulating enzyme activities and suppressing the genotoxicity of chemicals. Galangin is a member of the flavonol class of flavonoid.
Growth of a human mammary tumor cell line is blocked
by galangin, a naturally occurring bioflavonoid, and
is accompanied by down-regulation of cyclins D3, E,
Breast Cancer Research 2006. Department of Environmental Health, Boston University School of Public Health, Boston, MA, USA
This study was designed to determine if and how a non-toxic, naturally occurring bioflavonoid, galangin, affects proliferation of human mammary tumor cells. Our previous studies demonstrated that, in other cell types, galangin is a potent inhibitor of the aryl hydrocarbon receptor (AhR), an environmental carcinogen-responsive transcription factor implicated in mammary tumor initiation and growth control. Because some current breast cancer therapeutics are ineffective in estrogen receptor (ER) negative tumors and since the AhR may be involved in breast cancer proliferation, the effects of galangin on the proliferation of an ER-, AhRhigh line, Hs578T, were studied. Conclusion: Galangin is a strong inhibitor of Hs578T cell proliferation that likely mediates this effect through a relatively unique mechanism, suppression of cyclin D3, and not through the AhR. The results suggest that galangin bioflavonoid may be useful as a chemotherapeutic, particularly in combination with agents that target other components of the tumor cell cycle and in situations where estrogen receptor-specific therapeutics are ineffective.
Thank you for the newsletter. I "killed" my own breast
cancer, Stage IIa, about 18 months ago. I continue to
take my own formula. I refused chemotherapy and
radiation, because my research shows that it
actually increased my chances of getting cancer, in
comparison to doing nothing more than surgery. I opted
for a double mastectomy. Also, I continue to do
research to enhance my own formula: Lysine, Proline,
Arginine, L-Glutamine, Vit C, B complex, Vit D, Reishi
Mushrooms in capsul form, Shitakii Mushrooms in edible
form, and Shark Cartilage. I also took other
complimentary supplements, such as Vit E, Selenium,
Enclosed is a recent breast cancer article in which a bioflavinoid "Galangin" appears to inhibit cancer,
especially in persons who are chemotherapy resistance
(who isn't?), and who are HER negative. I am emailing
the article to you in hopes that:
a) someone can put my formula together and sell it to
cancer victims, and
b) You can produce and package "Galangin" in an
appropriate form, along with a proliferation of
knowledge about it to those with breast cancer.
A. There are quite a number of herbs or substances that have an influence on breast cancer in vitro and more studies are really needed. Take care and congratulations on your success. We really wish your health continues at its best.
Exp Biol Med (Maywood). 2013. Galangin induces human colon cancer cell death via the mitochondrial dysfunction and caspase-dependent pathway. It induced human colon cancer cell death through the alteration of mitochondria membrane potential and dysfunction. These results suggest that galangin induces apoptosis of HCT-15 and HT-29 human colon cancer cells and may prove useful in the development of therapeutic agents for human colon cancer.
Galangin inhibits proliferation of hepatocellular carcinoma cells by inducing endoplasmic reticulum stress. Food Chem Toxicol. 2013.
Arch Pharm Res. 2014. Galangin, a dietary flavonol inhibits tumor initiation during experimental pulmonary tumorigenesis by modulating xenobiotic enzymes and antioxidant status.