supplement benefit, side effects, 4 mg dosage information, risks, danger, no
prescription required, use for
Alzheimer's disease, over the counter mind enhancer
June 20 2016 by Ray Sahelian, M.D.
Galantamine is a cholinergic medicine available as a prescription medication and over the counter sold online or in health food stores. It can be isolated from several plants, including daffodil bulbs, but is now synthesized.
Benefits of the supplement, how it
works, which neurotransmitters does it influence?
Galantamine offsets reductions in central cholinergic neurotransmission in Alzheimer's disease by specifically and reversibly inhibiting the acetylcholinesterase enzyme. This allows more acetylcholine to be available in the brain. This chemical is also a nicotinic receptor agonist. Another herbal extract that has potential in the therapy of Alzheimer's disease is Huperzine A.
Being approved for the treatment of Alzheimer's disease in both the US and in Europe, galantamine has potential as therapy for dementia. It is currently not recommended for use by young individuals.
side effects, safety, toxicity, danger
Side effects of galantamine are similar to those of other cholinesterase inhibitors. High doses may lead to side effects such as nausea, vomiting, diarrhea, abdominal pain, and dyspepsia.
This is a formulation featuring galantamine, a phytonutrient extracted from the common snowdrop (Galanthus nivalis), daffodil (Narcissus pseudonarcissus, and spider lily (Lycoris radiata), among other plants.
As an acetylcholinesterase inhibitor, it competitively blocks the premature, age-related breakdown of the natural neurotransmitter acetylcholine, an essential molecule that supports memory function. Unlike other acetylcholinesterase inhibitors, galantamine also enhances nicotinic receptor activity, an effect long known to influence memory and intellectual activity.
Dosage: One pill in the morning a few times a week.
supplement pill 4 mg with choline for e
This natural product also contains the nutrients choline and vitamin B5, the precursor and cofactor, respectively, to the body's production of acetylcholine.
NOTE: Please consult with your physician before you purchase galantamine to make sure this product is appropriate for you. This natural medication is also sold as Reminyl, a prescription medicine.
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Galantamine for Alzheimer's disease, dementia
Acta Neurol Scand. 2014. Galantamine treatment in outpatients with mild Alzheimer's disease. Seventy-five patients (55% women; mean ADAS-cog 22.3; mean age 70.2 years) were treated for approximately 36 months. About 60% (n = 45) received a total daily dose of 24 mg galantamine at final visit. Galantamine was generally safe and well tolerated during the 3-year observation period. Cognition, behavior, and activities of daily living improved during 12 months treatment. At 3-year follow-up, worsening in all outcomes was measured; however, cognition remained improved compared with an untreated population.
Arq Neuropsiquiatr. 2014. Effects of galantamine and galantamine combined with nimodipine on cognitive speed and quality of life in mixed dementia: a 24-week, randomized, placebo-controlled exploratory trial (the REMIX study). The effects of galantamine (GAL) on quality of life (QoL) and cognitive speed, as well its effects combined with nimodipine (NIM) in Alzheimer disease (AD) with cerebrovascular disease (mixed dementia), have not been explored.METHOD:Double-blind, placebo-controlled, multicenter Brazilian trial, studying the effects of GAL/NIM vs. GAL/placebo (PLA) in mild to moderate mixed dementia. Patients were randomized to receive GAL/NIM or GAL/PLA for 24 weeks. Primary efficacy measures were changes on a computerized neuropsychological battery (CNTB) and QoL Scale in Alzheimer's Disease (QoL-AD) from baseline to week 24. Twenty-one patients received at least one drug dose (9 GAL/NIM and 12 GAL/PLA). Groups were matched for age, sex, education, cognitive and QoL scores at baseline. No significant differences were observed between groups on primary or secondary measures. QoL and cognitive performance showed significant improvement from baseline when all GAL-treated patients were analyzed. Adverse events were predominantly mild to moderate. GAL treatment improved QoL in mixed dementia, in addition to its previously known cognitive benefits. The combination GAL/NIM was not advantageous.
Cochrane Database Syst Rev. 2004.
Trials were identified from a search of the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group, last updated on in 2005 using the terms galanthamin, galantamin and Reminyl. Trials selected were randomised, double-blind, parallel-group comparisons of galantamine with placebo for a treatment duration of greater than 4 weeks in subjects with AD. This review shows consistent positive effects for galantamine for trials of 3 to 6 months duration. Although there was not a statistically significant dose-response effect, doses above 8mg/d were, for the most part, consistently statistically significant. Galantamine's safety profile is similar to that of other cholinesterase inhibitors with respect to cholinergically mediated gastrointestinal symptoms. It appears that doses of 16 mg/d were best tolerated in the single trial where medication was titrated over a 4 week period, and because this dose showed statistically indistinguishable efficacy with higher doses, it is probably most preferable initially. Longer term use of galantamine has not been assessed in a controlled fashion.
Long-term outcomes of galantamine treatment in patients
with Alzheimer disease.
Am J Geriatr Psychiatry. 2004.
The authors evaluated the long-term safety, efficacy, and tolerability of 24 mg/day in the treatment of Alzheimer disease by means of a 12-month, open-label extension of an earlier 5-month, double-blind, placebo-controlled trial. Results of this open-label extension support the findings from previous galantamine studies and demonstrate the safety and tolerability of this compound for up to 18 months.
Chronic fatigue syndrome
Effect of galantamine hydrobromide in chronic fatigue syndrome: a randomized controlled trial.
There is no established pharmacological treatment for the core symptoms of chronic fatigue syndrome (CFS). To compare the efficacy and tolerability of galantamine hydrobromide in patients with CFS. A total of 89 patients were randomly assigned to receive 2.5 mg of galantamine hydrobromide; 86 patients, 5 mg; 91 patients, 7.5 mg; and 86 patients, 10 mg (these patients received medicine in the tablet form 3 times per day); a total of 82 patients received matching placebo tablets 3 times per day. This trial did not demonstrate any benefit of galantamine over placebo in the treatment of patients with CFS.
Can you kindly tell me if galantamine use, in non Alzheimer's disease patients, can have a paradoxical reaction in which memory worsens?
I have not come across studies that indicate a worsening of memory with the use of this medication, but it is possible that the wrong dosage, often too high, could have unexpected results, or could negatively interact with other medications and supplements, or there could be individuals who respond in a manner that is different than other users.
Could this product be taken for just simple, 'severe'
forgetfulness by an otherwise healthy person?
Perhaps it could help but it is difficult to know without first trying it. It is a good idea to take frequent breaks from use.
Treatment with galantamine in combination with atropine, protects guinea pigs from lethal doses of the nerve agents sarin and soman and the insecticide parathion. The toxic effect of these "organophosphorus" compounds derives from irreversible blockage of an enzyme critical to nerve function. The end result can be seizures and cardiac arrest. At present, atropine and other drugs are used to treat the toxic effects of organophosphorus compounds. However, these treatments have various limitations, including an inability to fully protect the brain from damage. Galantamine protects nerves from these chemicals by temporarily blocking the same enzyme. Researchers tested the effects of galantamine in guinea pigs exposed to lethal doses of sarin, soman, and paraoxon, the biologically active form of parathion. Atropine was given to counter the effects of these agents outside the brain. Galantamine plus atropine safely and effectively counteracted the toxic effects of the organophosphorus compounds. Moreover, galantamine was well tolerated at the dosages needed to prevent death. Proceeding of the National Academy of Sciences, 2006.
Primary progressive aphasia
Thirty-six behavioral variety FTD and primary progressive aphasia (PPA) patients were treated in an open-label period of 18 weeks and a randomized, placebo-controlled phase for 8 weeks. Galantamine is not effective in the behavioral variety of FTD, but a trend of efficacy is shown in the aphasic subgroup. Dement Geriatr Cogn Disord. 2008. Galantamine in frontotemporal dementia and primary progressive aphasia. Cognitive Neurology and Alzheimer Research Centre, St. Joseph's Hospital, London, Ont.
Q. My father had Alzheimer's starting by around age 70. I have had too many senior moments so I was happy to try a galantamine 8 mg pill. The results are immediately effective but as I am only 56 years old and want to be cognizant for as long as possible, I am taking it just once every 3 days. I am afraid of building up a resistance to it and needing stronger and stronger doses. Is taking one 8 mg tablet every 3 days as safe as taking one galantamine 4 mg tablet every day? I happened to go to another company first where I purchased 120 tablets that are 8-mg each. By safe I only mean, what is the best way to not build up resistance to the dosage so that i need stronger doses? Although I prefer to start with the smaller dose i hate to throw out the 120 pills i bought in order to start with 4 mg. These are capsules which can't really be cut in half. I am an active person who is not considered to be cognitively impaired. I just notice too many senior moments and i don't want to get worse. I occasionally forget i put a teapot on or forget to get something at the store. Or sometimes I walk to the other end of the house to get something and then say to myself, now what did i want to get?
A. There is not enough long term human research to know the safety of this substance when taken for many years or decades. The safest option is to take the least amount that works. Some people may respond to galantamine 4 mg every other day, others may prefer 8 mg every third day. There are no right or wrong answers since what works for one person may not work for another. There are many other supplements that could be useful to maintain healthy memory and mind and it may be a good idea to occasionally take a break from using a galantamine supplement and try other brain boosters. You may find the book Mind Boosters to be helpful in this regard.
Can a 85 year old woman take GalantaMind and Aricept together I'm out looking for answers to this question they told me tale Aricept one day then take GalantaMind the next and so forth till I get to the third week Is this a safe way to do it cautioned by research into this product.
Combining Aricept and galantamine products such as GalantaMind the same day may produce or increase side effects. We don't have any experience with alternating the use of GalantaMInd and Aricept, but this is an interesting idea and worth a try under medical supervision and in low dosages. An older person can have side effects to medications and supplements at a lower dosage than younger individuals, therefore the galantamine dosage and the Aricept dosage should be low even if one needs to take a portion of a tablet or capsule.
It galantamine the same generic version of Razadyne?
As far as we know, yes.
What are the differences between galantamine supplement and the physician prescribed Reminyl prescription drug?
This is a good question. As far as we know, they are identical, but we really have not seen the exact chemical analysis of Reminyl drug to know for sure.
Clinical pharmacokinetics of galantamine.
Clin Pharmacokinet. 2003.
Vascular dementia and diffuse Lewy body dementia are also associated with significant defects in cholinergic function. Galantamine is about 90% bioavailable and displays linear pharmacokinetics. It has a relatively large volume of distribution and low protein binding. Metabolism is primarily through the cytochrome P450 system, specifically the CYP2D6 and CYP3A4 isoenzymes. Population pharmacokinetic modelling with galantamine has shown that the variables affecting clearance are age, sex, and bodyweight. Model simulations demonstrate the importance of a slower dose-escalation schedule in patients with moderate hepatic impairment. In several large trials, galantamine has been shown to be well tolerated, with most adverse events being mild-to-moderate and gastrointestinal in nature.