Gamma Oryzanol is found in rice bran oil and other plants. Gamma oryzanol has antioxidant activity and may be helpful in maintaining healthy cholesterol levels.

Source Naturals - Gamma Oryzanol, 60 mg, 100 Tablets

Gamma Oryzanol is a naturally occurring plant sterol derived from rice bran oil.

Gamma Oryzanol Supplement Facts:
Calcium 31 mg 4 %
Gamma-oryzanol 60 mg *

Suggested Use: Men - 1 to 3 tablets; Women- 1 or 2 tablets. Take once daily, preferably on an empty stomach (3 or more hours after a meal).
* Gamma Oryzanol daily value not established.

Other Ingredients: dibasic calcium phosphate, microcrystalline cellulose, stearic acid, modified cellulose gum, and magnesium stearate.

Suitable for vegetarians and HYPOALLERGENIC: Contains no yeast, dairy, egg, gluten, corn, soy or wheat. Contains no sugar , starch, preservatives, or artificial color, flavor or fragrance.

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Summary
Gamma-oryzanol is extracted from rice bran oil and has a wide spectrum of biological activities; in particular, it has antioxidant properties and is often used in cosmetic formulations as a sunscreen. Gamma Oryzanol may have beneficial effects on cholesterol.

Gamma Oryzanol Research Update
Antioxidant activity of steryl ferulate extracts from rye and wheat bran.
J Agric Food Chem. 2005 Apr 6;53(7):2503-10.
Antioxidant activity of steryl ferulates from other sources than rice have not yet been studied much, despite the fact that rice steryl ferulates (gamma-oryzanol) have been shown to possess good antioxidant activity. In this study, steryl ferulate extracts from wheat or rye bran were studied for their capability to inhibit hydroperoxide formation in bulk methyl linoleate and methyl linoleate emulsion. Further, their activity to scavenge DPPH radicals was analyzed. The activities were compared to synthetic steryl ferulates, rice steryl ferulates, ferulic acid, and alpha-tocopherol. Nonrice cereal extracts of steryl ferulates exhibited good antioxidant activity, especially in the bulk lipid system. The radical scavenging activity was similar to that of nonesterified ferulic acid, indicating that the ferulic acid moiety is responsible for the antioxidant properties. This study illustrates a new aspect to the health-promoting properties of rye and wheat.

Antioxidant activity of gamma-oryzanol: mechanism of action and its effect on oxidative stability of pharmaceutical oils.
Int J Pharm. 2005 Aug 11;299(1-2):146-54.
The first objective of the present investigation was to elucidate the molecular mechanism(s) of the antioxidant activity of gamma-oryzanol by utilising different in vitro model systems, such as scavenging of stable DPPH radical, OH and O2- radicals scavenging, and azocompound AMVN-initiated lipid peroxidation. The effect of gamma-oryzanol on the oxidative stability of vegetable oils of pharmaceutical and cosmetic interest was then evaluated in a oxidation accelerate test and compared with the effect of the well-known antioxidants BHA and BHT. Our results demonstrate that gamma-oryzanol is an organic radical scavenger able to prevent AMVN-triggered lipoperoxidation. Moreover, when added to oils at concentrations ranging between 2.5 and 10 mmol/kg, gamma-oryzanol shows a dose-dependent increase of the induction times; in particular, it improved the oxidative stability of oils very prone to lipoperoxidation because of their high content of polyunsaturated fatty acids. On the ground of our results, we can conclude that gamma-oryzanol may have a potential application for the stabilization of lipidic raw materials.

Increased immune response in mice consuming rice bran oil.
Eur J Nutr. 2005 Feb 22;
Polyunsaturated fatty acids play a key role in a number of biological functions. Rice bran oil is rich in linoleic acid, an essential n-6 fatty acid. n-6 fatty acids are said to have proinflammatory effects as a result of an increase in n-6 fatty acidderived eicosanoids. Rice bran oil is also rich in gamma-oryzanol, a compound from the unsaponifiable fraction, with antioxidant properties. Our results suggest that although gamma-oryzanol may modulate the immune system, it is not responsible for the overall immunostimulation effect seen for Rice bran oil . CONCLUSIONS : Rice bran oil -enriched diets could be useful in situations where a potentiation of the immune response was required. The fatty acids composition, more than the unsaponifiable fraction, might be responsible for this effect.

Similar cholesterol-lowering properties of rice bran oil, with varied gamma-oryzanol, in mildly hypercholesterolemic men*.
Eur J Nutr. 2005 Mar;44(3):163-73.
The cholesterol lowering properties of rice bran oil containing differing amounts of non-saponifiable components have not been studied in humans, to our knowledge. To evaluate cholesterol lowering effects of rice bran oil, with low and high amounts of gamma-oryzanol (ferulated plant sterols) in mildly hypercholesterolemic men. CONCLUSIONS : rice bran oil supplementation at ca. 50% total fat intake improved lipoprotein pattern in mildly hypercholesterolemic men. Methylated sterols in gamma-oryzanol are thought to be largely ineffective at inhibiting dietary cholesterol absorption, but could enhance cholesterol-lowering ability of 4-desmethylsterols. Assuming all ferulated sterols become de-ferulated in the gut, low and high gamma-oryzanol containing rice bran oil provided intestinal loads of 453 and 740 mg/d free 4-desmethylsterols, respectively. This intestinal load of 453-740 mg/d of efficacious free plant sterol equivalents had identical effects on lipoproteins.

Effect of gamma-oryzanol on cytochrome P450 activities in human liver microsomes.
Biol Pharm Bull. 2004 Jul;27(7):1151-3.
The effects of gamma-oryzanol, a drug mainly used for the treatment of hyperlipidaemia, on several cytochrome P450 (CYP) specific reactions in human liver microsomes were investigated to predict drug interactions with gamma-oryzanol in vivo from in vitro data. Gamma-Oryzanol had little inhibitory effects on CYP activities, indicating that this compound would not be expected to cause clinically significant interactions with other CYP-metabolized drugs at expected therapeutic concentrations.

Prevention of brain protein and lipid oxidation elicited by a water-soluble oryzanol enzymatic extract derived from rice bran.
Eur J Nutr. 2003 Dec;42(6):307-14.
The antioxidant capacity of rice bran (due mainly to its gamma-oryzanol content) is very well known. We have recently developed a water-soluble gamma oryzanol enzymatic extract, which shows a greatly increased functionality. AIM OF THE STUDY: The aim of our study is the evaluation of the antioxidant potential of gamma oryzanol enzymatic extract in an ex vivo model to compare its protective capacity against oxidative damage by active-oxygen substances and free radicals (mainly the peroxyl radical) to biomolecules (such as proteins and lipids) with that of antioxidants, such as Trolox (a water-soluble derivative of vitamin E), melatonin, and folic acid. CONCLUSION: Gamma oryzanol enzymatic extract is a new potential antioxidant agent from rice bran that shows a high free-radical-scavenging capacity and prevents protein oxidation and lipid peroxidation when cells ex vivo are exposed to free radicals.

Rice bran oil and gamma-oryzanol in the treatment of hyperlipoproteinaemias and other conditions.
Phytother Res. 2001 Jun;15(4):277-89.
Diet is the first (and sometimes the only) therapeutic approach to hyperlipoproteinaemias. Rice bran oil and its main components (unsaturated fatty acids, triterpene alcohols, phytosterols, tocotrienols, alpha-tocopherol) have demonstrated an ability to improve the plasma lipid pattern of rodents, rabbits, non-human primates and humans, reducing total plasma cholesterol and triglyceride concentration and increasing the high density lipoprotein cholesterol level. Other potential properties of rice bran oil and gamma-oryzanol, studied both in vitro and in animal models, include modulation of pituitary secretion, inhibition of gastric acid secretion, antioxidant action and inhibition of platelet aggregation. This paper reviews the available data on the pharmacology and toxicology of rice bran oil and its main components with particular attention to those studies relating to plasma lipid altering effects.

The effects of gamma-oryzanol supplementation during resistance exercise training.
Int J Sport Nutr. 1997 Dec;7(4):318-29. Fry AC, Bonner E, Lewis DL, Johnson RL, Stone MH, Kraemer WJ.
Exercise and Sport Science Laboratories, University of Memphis, TN 38152
To determine the effectiveness of gamma-oryzanol supplementation, weight-trained males were randomly divided into supplemented (G-O) and control placebo (Con) groups. The G-O group ingested 500 mg.day-1 of gamma-oryzanol according to manufacturer's instructions. Test batteries were administered before (T1), after 4 weeks (T2), and after 9 weeks (T3) of a periodized resistance exercise program. Both groups demonstrated significant increases in 1 repetition maximum muscular strength (bench press and squat) and vertical jump power, with no differences between the groups. No differences between groups were observed for measures of circulating concentrations of hormones (testosterone, cortisol, estradiol, growth hormone, insulin, beta-endorphin), minerals (calcium, magnesium), binding protein (albumin), or blood lipids (total cholesterol, triglycerides, HDL-cholesterol). Resting cardiovascular variables decreased similarly for both groups. These data suggest that 9 weeks of 500 mg.day-1 of gamma-oryzanol supplementation does not influence performance or related physiological parameters in moderately weight-trained males.

Gammaoryzanol emails
Q. Can I take a gammaoryzanol supplement the same day as serrapeptase or mangosteen?
     A. You can probably take it with mangosteen, but there is not enough known about serrapeptase to know for sure.