Gastroesophageal reflux is both a normal phenomenon that occurs in the general population and a disease causing phenomenon that can result in mild to severe symptoms. Gastroesophageal reflux disease (GERD) can be described as any symptomatic clinical condition that results from the reflux of stomach or duodenal contents into the esophagus. Excess weight and cigarette smoking increase the risk of GERD. Eating less could help reduce symptoms of GERD.
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Research Update newsletter. Twice a month you will receive an email with a
discussion
of several studies on various supplements and natural medicine topics, including
GERD diet research, and
their practical interpretation by Ray Sahelian, M.D.
GERD Diet - GERD Treatment
Losing weight is the most important long term strategy for reducing GERD
symptoms, one of these symptoms being
heartburn. New research indicates that losing weight and elevating the head of
the bed are effective measures for people with heartburn caused by GERD. These
strategies are associated with reduction in heartburn symptoms and acid levels
in the esophagus. However, there is less evidence that avoiding chocolate, spicy
foods, mint, citrus, fatty foods, carbonated beverages, coffee, or that late
night meal -- which is often recommended -- will relieve GERD-associated
heartburn.
The following suggestions have been made by doctors,
but the research supporting these suggestions is not as strong as losing weight
and elevating the head of the bed. Nevertheless, if it works for you give it a
try.
Decrease fat intake. Studies show diets high in fat may be associated with a
higher risk of GERD.
Increase intake of fiber
Reduce or avoid alcohol or coffee
Stop smoking
Sleep several hours after eating. If you suffer from acid reflux disease,
you may be going to bed too soon after your evening meal. A shorter
dinner-to-bed interval is significantly associated with an increased risk of
GERD. It is generally recommended that patients with GERD refrain from eating
within three hours of going to sleep.
Proton pump inhibitors as a last resort.
Supplements for GERD
Some people find aloe vera juice to be helpful as a GERD treatment.
Regression of gastroesophageal reflux disease symptoms using dietary
supplementation with melatonin, vitamins and aminoacids: comparison with
omeprazole.
J Pineal Res. 2006 Oct;41(3):195-200. Depto. de Farmácia-Universidade
Estadual da Paraíba, Av das Baraúnas, 351/Campus Universitário, Bodocongó/Campina
Grande-PB-Brazil-CEP 58109-753, Brazil.
The aim of this study was to investigate if a dietary supplementation
containing: melatonin, l-tryptophan, vitamin B6, folic acid, vitamin B12,
methionine and betaine would help patients with GERD, and to compare the
preparation with 20 mg omeprazole. Melatonin has known inhibitory activities on
gastric acid secretion and nitric oxide biosynthesis. Nitric oxide has an
important role in the transient lower esophageal sphincter relaxation (TLESR),
which is a major mechanism of reflux in patients with GERD. Others biocompounds
of the formula display anti-inflammatory and analgesic effects. A single blind
randomized study was performed in which 176 patients underwent treatment using
the supplement cited above (group A) and 175 received treatment of 20 mg
omeprazole (group B). All patients of the group A (100%) reported a complete
regression of symptoms after 40 days of treatment. On the other hand, 115
subjects (65%) of the omeprazole reported regression of symptoms in the same
period.
Dr. Sahelian comments: I wonder if melatonin or tryptophan by
themselves would work well, too.
Complications of GERD
Complications of GERD include esophageal erosion, esophageal ulcer, and
esophageal stricture; replacement of normal esophageal epithelium with abnormal
(Barrett's) epithelium; and pulmonary aspiration. The majority of patients with
GERD will have a normal esophagus upon endoscopy. A physician can diagnose and
evaluate the severity of GERD.
GERD Symptoms
Heartburn is described as a burning pain in the stomach that rises up
towards the chest or towards the neck. Additional symptoms and signs include
constant throat clearing, foreign body sensation in the throat, dental decay,
chest pain, hoarseness, chronic cough, sore throat.
Most episodes of GERD occur during the day, usually after eating; some sufferers also experience reflux during sleep. Nocturnal reflux is commonly associated with a higher risk and a higher degree of esophagitis: acid remains in the esophagus for prolonged periods because there is less swallowing and less saliva produced to neutralize the acid. The symptoms and degree of esophageal mucosal damage are primarily determined by the pH concentration of the refluxate and the duration of esophageal acid exposure.
Causes of GERD
Causes of GERD are often due to transient lower esophageal sphincter
(LES) relaxations, decreased LES resting tone, delayed stomach emptying,
ineffective esophageal clearance, and diminished salivation. Other contributing
factors to GERD include the potency of the refluxed material, and the inability
of the esophageal tissue to resist injury and repair itself.
Factors that may make symptoms of GERD worse include
smoking, caffeine, fatty foods, overeating with gastric distention,
tight clothing, the presence of a hiatal hernia, and certain medications.
People with GERD swallow air and belch more frequently
than those without GERD, but the air swallowing does not appear to cause or
worsen the condition.
GERD Drugs May not be
Safe
Popular GERD drugs such as proton-pump inhibitors that block stomach acid
production heighten the risk of an increasingly common infectious form of
diarrhea.Taking such drugs as AstraZeneca's Nexium and Losec or their generic
versions significantly increase the risk of diarrhea blamed on the Clostridium
difficile bacteria. Frequently prescribed anti-heartburn drugs called H2
antagonists that include GlaxoSmithKline's Zantac were found to double the risk
of the bacterial diarrhea. The drugs reduce gastric acid, allowing for bacteria
to multiply in the digestive system. Clostridium is the third-most common type
of infectious diarrhea in patients aged 75 and older. Exposure to Clostridium
difficile bacteria, which causes infection and inflammation of the intestine,
previously occurred mostly during hospital stays, but cases have increasingly
been contracted in community settings. While antibiotics formerly blamed for
outbreaks of the illness have declined in use, the acid-blocking drugs have
become steadily more popular to treat ulcers and conditions such as gastric
reflux disease.
Complications of GERD
Complications of GERD include esophageal erosion, esophageal ulcer, and
esophageal stricture; and pulmonary aspiration. A serious complication that can
occur with long standing GERD is replacement of normal esophageal epithelium
with abnormal epithelium. When this happens, it is called Barrett's esophagus.
Barrett's esophagus can eventually turn into cancer of the esophagus.
The majority of patients with GERD will have a normal
esophagus upon endoscopy. If there are deep breaks in the lining of the
esophagus, this can lead to esophageal ulcers and gastrointestinal bleeding.
GERD Diagnosis
A wireless capsule can be swallowed and the pH of the esophagus tested.
The capsule transmits the pH for a day or two. This pH monitoring can help
diagnose acid reflux.
GERD Research Update
Dietary intake and the risk of gastro-oesophageal reflux disease: a cross
sectional study in volunteers.
Gut. 2005 Jan;54(1):11-7. El-Serag HB, Satia JA, Rabeneck L.
Section of Gastroenterology and Health Services Research, The Houston Veterans
Affairs Medical Center, Houston, TX
Although diet has been associated with gastro-esophageal reflux disease (GERD),
the role of dietary components (total energy, macro and micronutrients) is
unknown. We examined associations of GERD symptoms with intakes of specific
dietary components. In this cross sectional study, high dietary fat
intake was associated with an increased risk of GERD symptoms and erosive
esophagitis while high fiber intake correlated with a reduced risk of GERD
symptoms. It is unclear if the effects of dietary fat are independent of
obesity.
GERD -- Pepsin, the main digestive
enzyme
in stomach juice, is often found in middle ear fluid obtained from children with
chronic otitis. This suggests an association between the ear problem and gastro-esophageal
reflux disease, or GERD, in which gastric juice leaks into the throat. However,
these children do not show an increased rate of GERD symptoms.
GERD treatment emails
Q. I read on one of the sites that
Digestive Enzymes
may be beneficial to patients suffering from GERD. Do you recommend a digestive
enzyme supplement such as the one on the Physician Formulas site? I am trying to
get rid of the chronic bloating which I am experiencing with GERD.
A. We have not seen any studies evaluating digestive
enzymes and gerd.
2nd email: I started Daily Essential Enzymes on January
9, 2006. Today is Wednesday, January 11th. I'm not on any proton inhibitors and
so far, I have not felt the need to take an antacid for relief. I read a medical
article someplace which suggested that digestive enzymes sometimes relieve gerd
symptoms. Also, I'm monitoring abdominal bloating. Will stay in touch and let
you know if the condition improves, deteriorates or remains the same.
Q. I was wondering, with some
erectile
dysfunction medicines / formulas, the
erections sometimes last
for a little while longer than they should really and i was wondering what along
with how long the erection would last (meaning after sex as well) other side
effects might be cause for alarm? My main goal is to last longer and get more
out of sex but without any nasty side effects or having it last longer than it
should...Also, is there any interference with Passion RX and say Acid Reflux /
GERD and medicines used to treat GERD? Currently I am taking a Proton Pump
Inhibitor called Protonix and I want to make sure that there will be no
interaction or negative side effect!
Q. We have never tested
Passion Rx with gerd
medicines so we don't know. If your doctor approves, you could start with a
third of a capsule and gradually increase over the next few days to see at what
dose you notice a benefit but no side effect. The slow low dose approach may
take longer, but it minimizes side effects.
Q. I was happy to discover aloe juice for GERD. It is effective, almost as much as Prilosec, but with no side effects.
Q. I was wondering what you could suggest to
support, control and alleviate GERD? I have had bad reactions to four
different medications for the treatment of acid reflux and have had little
to no acid reduction with two others. I am a healthy eater and have been
modifying my diet further in hopes of reducing and eliminating trigger
foods. I desperately want to deal with the GERD without medication if at
all possible. Presently I am taking Atenolol for high blood pressure.
A. We can't give specific suggestions but perhaps you can discuss
the natural treatment for GERD mentioned on this page with your doctor.