October 24 2015 by
Ray Sahelian, M.D.
The British drug maker GlaxoSmithKline will no longer pay doctors to promote its products and will stop tying compensation of sales representatives to the number of prescriptions doctors write, its chief executive said, effectively ending two common industry practices that critics have long assailed as troublesome conflicts of interest, New York Times.
GlaxoSmithKline Plc is Europe's biggest drug company. Headquartered in the UK and with operations based in the US, GlaxoSmithKline is one of the pharmaceutical industry leaders, with an estimated seven per cent of the world's pharmaceutical market. The British pharmaceutical giant has some of its executives broken the law in China in 2013, regarding a bribery and corruption scandal that has engulfed its China operations.
Glaxosmithkline pharmaceutical produces medicines that treat six major disease
areas – asthma, virus control, infections, mental health, diabetes and digestive
conditions. In addition, Glaxosmithkline is a leader in the important area of
vaccines and is developing new treatments for cancer.
Glaxosmithkline inc Drugs: Glaxo drugs
Aclovate - alclometasone dipropionate
Advair Diskus - salmeterol, fluticasone propionate for asthma. Advair is the biggest selling drug for GlaxoSmithKline, with $5.7 billion of sales in 2005. GlaxoSmithKline is promoting Advair for COPD although there is no proof yet that Advair use would extend life span. See the following web page for other potential treatment in COPD.
Agenerase - amprenavir
Albenza - albendazole
Alkeran - melphalan
Amerge - naratriptan
Amoxil - amoxicillin
Ancef - cefazolin
Argatroban - argatroban
Arixtra - fondaparinux sodium
Arranon - nelarabine
Augmentin - amoxicillin / clavulanate potassium
Avandamet - rosiglitazone maleate and metformin hydrochloride. One of the biggest sellers for GlaxoSmithKline.
Avandia - rosiglitazone maleate. One of the biggest sellers for GlaxoSmithKline. Avandia, GlaxoSmithKline Plc's widely used drug for treating type 2 diabetes, increases the risk of heart death and the risk of heart attack. John Buse, president-elect of the American Diabetes Association and faculty member at the University of North Carolina in Chapel Hill, cited "a worrisome trend in cardiovascular deaths and severe adverse events" among patients using the drug in a letter to the FDA in March 2000.
Avandaryl - rosiglitazone maleate and glimepiride
Avodart - dutasteride
Bactroban - mupirocin
Beconase - beclomethasone dipropionate
Bexxar - tositumomab
Boniva - ibandronate sodium
Ceftin - cefuroxime axetil
Ceptaz - ceftazidime
Combivir - zidovudine and lamivudine
Coreg - carvedilol
Cutivate - fluticasone propionate
Daraprim - pyrimethamine
Dexedrine - dextroamphetamine sulfate - GlaxoSmithKline Plc has added a strong warning about possible heart risk to its attention deficit hyperactivity drug Dexedrine,. Packaging for Dexedrine will also include information about possible psychiatric adverse events, like hallucinations and mania, linked to stimulants. GlaxoSmithKline said it will caution patients and doctors that "misuse of amphetamines may cause sudden death and serious cardiovascular adverse events." Dexedrine will also include warnings about the risk of sudden death, hypertension and other concerns associated with stimulant treatment in children and adolescents who have heart problems.
Digibind - sorbitol BP and sodium chloride BP
Dyazide - hydrochlorothiazide / triamterene
Epivir - lamivudine
Epzicom - abacavir sulfate and lamivudine
Eskalith / Eskalith CR - lithium carbonate
Flolan - epoprostenol sodium
Flonase - fluticasone propionate
Flovent - fluticasone propionate
Fortaz - ceftazidime
Hycamtin - topotecan hydrochloride
Imitrex - sumatriptan succinate
Lamictal - lamotrigine -
the company warned in August, 2006 that there
is an increased risk of cleft lip or cleft palate when the company's
antiepileptic drug Lamictal is used during early pregnancy. GlaxoSmithKline said
cleft palate deformity was detected at "an elevated rate" in infants whose
mothers used the treatment during the first three months of pregnancy, compared
with those who weren't exposed to the drug. Antiepileptic drugs have been
associated with oral clefts, while other factors including smoking, heavy
alcohol intake, various infections, folic acid deficiency, and vitamin A
intoxication, have also contributed. Oral clefts occur 0.5 to 2.16 times per
1,000 births. GlaxoSmithKline advised patients who are being treated with
Lamictal and who are, or intend to become pregnant, to discuss treatment with
Lanoxin - digoxin
Leukeran - chlorambucil
Levitra is an impotence drug sold by GlaxoSmithKline PLC and Schering-Plough Corp.
Lexiva - fosamprenavir calcium
Lotronex - alosetron hydrochloride
Malarone - atovaquone and proguanil hydrochloride
Mepron - atovaquone
Myleran - busulfan
Oxistat - oxiconazole nitrate
Parnate - tranylcypromine sulfate
Paxil - paroxetine hydrochloride for depression - Newer antidepressants, already suspected of raising the risk of suicide in some patients, may also cause a few people to become violent. People who take Paxil from GlaxoSmithKline are more likely to have what is called a "hostility event" as those given a placebo.
Purinethol - mercaptopurine BP
Relafen - nabumetone
Relenza - zanamivir
Requip - ropinirole hydrochloride
Retrovir - zidovudine
Serevent - salmeterol xinafoate
Stelazine - trifluoperazine hydrochloride
Tabloid - thioguanine
Tagamet - cimetidine, cimetidine hydrochloride
Temovate - clobetasol propionate
Thorazine - chlorpromazine
Ticar - ticarcillin disodium
Timentin - ticarcillin disodium / clavulanate potassium
Trizivir - abacavir sulfate/ lamivudine/zidovudine
Valtrex - valacyclovir hydrochloride
Ventolin - albuterol
Wellbutrin - bupropion hydrochloride
Zantac - ranitidine hydrochloride
Ziagen - abacavir sulfate
Zinacef - cefuroxime (no sulfate)
Zofran - ondansetron hydrochloride
Zovirax - acyclovir
Zyban - bupropion hydrochloride SR
Glaxosmithkline pharmaceutical also markets other products:
* over-the-counter (OTC) medicines including Gaviscon and Panadol
* dental products such as Aquafresh and Macleans
* smoking control products Nicorette / Niquitin
* nutritional healthcare drinks such as Lucozade, Ribena and Horlicks
GlaxoSmithKline has a vaccine manufacturing plant in the Hungarian town of Godollo, just north of Budapest. GlaxoSmithKline plans to manufacture DPT, a combination of three vaccines to immunise against diphtheria, pertussis and tetanus, at the Godollo plant. It said it plans output in the order of 100 million units a year, which would meets its entire world-wide needs.The company employs around 360 people in Hungary and had turnover of 23 billion forints ($106 million) in 2005.
GlaxoSmithKline and FDA scientists confirm that DNA from porcine circovirus 1 (PCV1) has been detected in the Rotarix vaccine. Based on these findings, the FDA recommends that healthcare providers temporarily suspend use of this vaccine while the agency conducts further investigations. No safety risks are evident at this time. March 2010.
GlaxoSmithKline Consumer Healthcare
Xenical is manufactured by Roche and co-promoted in the U.S. by GlaxoSmithKline Consumer Healthcare. Over the counter orlistat is called by the brand name Alli.
GlaxoSmithKline distorted Paxil drug test data: BBC
GlaxoSmithKline Plc was accused in January 2007 of distorting clinical trial results of its antidepressant Seroxat, or Paxil, and covering up a link with suicide in teenagers. Glaxo attempted to show that Seroxat worked for depressed children despite failed clinical trials and that Glaxo employed ghostwriters influenced "independent" academics. Regulators in 2003 recommended against using Seroxat in people under 18 due to an increase in the rate of self-harm and potentially suicidal behaviors in this age group when the drug was prescribed. But Glaxo said the increase in suicidal thinking was only revealed when results of separate clinical studies were pooled at the end of its research program, at which point the company brought the findings to the attention of regulatory authorities.
GlaxoSmithKline plc and Tax Evasion
GlaxoSmithKline Plc will pay a net $3.1 billion to settle an ongoing tax dispute with the U.S. government. The U.S. Internal Revenue Service (IRS) claimed back tax from GlaxoSmithKline after alleging it engaged in so-called "transfer pricing", a practice designed to minimize U.S. taxable profits by overpaying foreign subsidiaries for product supplies. The settlement covers an original dispute for the period 1989-2000, which was due to go to trial in February 2007, as well as the subsequent years 2001-2005.
2006 - GlaxoSmithKline Plc has bought privately owned biotech company Domantis Ltd, a specialist in developing a new generation of antibody drugs, for 230 million pounds ($453 million). The all-British deal is the latest in a string of acquisitions by large pharmaceutical companies eager to tap new biotech know-how to boost their pipelines of future medicines.
Donation of flu vaccine
British drugmaker GlaxoSmithKline has agreed to donate 50 million doses of pandemic H1N1 vaccine to the World Health Organization for use in developing countries in coming months. GSK, which makes the Pandemrix H1N1 vaccine being used in pandemic vaccination programs in Britain and other European countries, said it expected to prepare the first shipments of vaccine to the WHO by the end of November 2009.
Q. Enjoyed your site, very informative. Can you at least tell me where I can find info on any possible interactions between 5HTP and Wellburtrin. Since I have started taking Wellbutrin in the morning I stopped my 5-HTP at night. Have not had a good nights sleep in weeks but am afraid to combine the two. I would love to ask my Dr. but he has no idea what 5-HTP even is. So I'm on my own. Could you at least refer me to someone who can help. I even contacted Glaxo Smith Kline and they were no help.
A. Wellbutrin influences dopamine and other neurotransmitters. At this point it is not clear what the interaction would be when this drug is combined with 5-HTP. Hence, one needs to be cautious. I can't blame GlaxoSmithKline for not answering this question since your doctor would need to decide.