Glucuronolactone by Ray Sahelian, M.D.

Glucuronolactone is found naturally in the body as a substance produced by the metabolism of glucose in the human liver.
   Glucuronolactone is a popular ingredient in energy drinks. Most of these drinks contain caffeine, but glucuronolactone is included because it is thought to fight fatigue and provide a sense of well-being.  I was not able to find a human study that evaluated the effects of glucuronolactone on mood or energy when provided just by itself.

Diet Rx natural appetite suppressant
If you would like to eat less and have more energy, consider a product called Diet Rx. This natural appetite suppressant works without stimulants. Diet Rx has no glucuronolactone, no added caffeine, ephedra, ephedrine alkaloids, synephrine, hormones, guarana, ginseng, or stimulating amino acids. 

Benefits of Diet Rx
All natural appetite suppressant, decreases appetite so you eat less
Helps you maintain healthy blood sugar levels
Helps you maintain healthy cholesterol and lipid levels
Provides a variety of antioxidant from two dozen herbs and nutrients
Provides healthy fiber
Improves energy naturally which makes you want to walk and use up more calories.
Balances mood
Improves mental concentration and focus
Improves will power and choice of food selection

You can buy Diet Rx here, find out the ingredients, and see a list of hundreds of high quality natural supplement products

Benefit of glucuronolactone supplement
As of January of 2008, I could not find any published research regarding the use of a glucuronolactone supplement by itself. If your purpose for taking glucuronolactone is to enhance energy, consider an excellent and healthy option with MultiVit Rx. It provides an excellent and natural all day energy boost.

Glucuronolactone Research
Efficacy of a 'functional energy drink' in counteracting driver sleepiness.
Physiol Behav. 2002 Mar;75(3):331-5. Reyner LA, Horne JA.
Sleep Research Centre, Loughborough University,Loughborough, Leicestershire LE11 3TU, UK.
Coffee is often used as an effective countermeasure to driver sleepiness. However, the caffeine levels in coffee are variable, whereas certain proprietary "functional energy drinks" contain known levels of caffeine (and other ingredients). We investigated the effectiveness of a well-known energy drink in reducing sleepiness in drivers. Twelve healthy young adults drove an instrumented car simulator between 14:00 and 17:00 h. Their sleepiness was enhanced by sleep restriction to 5 h the night before. Following a pretreatment 30-min drive and at the beginning of a 30-min break, participants were given double-blind 250-ml energy drink (containing sucrose, glucose, 80-mg caffeine, taurine, glucuronolactone and vitamins) vs. a control drink with the same volume and same taste but without caffeine, taurine and glucuronolactone. Two hours of continuous driving ensued. Compared with the control, the energy drink users significantly reduced sleep-related driving incidents and subjective sleepiness for the first 90 min of the drive.

The effects of red bull energy drink on human performance and mood.
Amino Acids. 2001;21(2):139-50. Alford C, Cox H, Wescott R.
Psychology Department, University of the West of England, Bristol, United Kingdom.
The effects of Red Bull Energy Drink, which includes taurine, glucuronolactone, and caffeine amongst the ingredients, were examined over 3 studies in a total of 36 volunteers. Assessments included psychomotor performance (reaction time, concentration, memory), subjective alertness and physical endurance. When compared with control drinks, Red Bull Energy Drink significantly (P < 0.05) improved aerobic endurance (maintaining 65-75% max. heart rate) and anaerobic performance (maintaining max. speed) on cycle ergometers. Significant improvements in mental performance included choice reaction time, concentration (number cancellation) and memory (immediate recall), which reflected increased subjective alertness. These consistent and wide ranging improvements in performance are interpreted as reflecting the effects of the combination of ingredients.

The metabolism of oral glucurolactone to serum D-glucarate is by the hepatic cytochrome P450 enzyme system.

D-Glucuronolactone emails
Q. I would like to ask if you have a glucuronolactone supplement.
   A. Not at this time.