Gonadotropin by Ray Sahelian, M.D.

 

gonadotropin


Human chorionic gonadotropin use in sports

Because hCG and estrogen blockers produce marked increase in blood testosterone concentration in men, this provides strong evidence to support the banning of hCG and estrogen blockers in men. In women, however, the negligible effect on blood testosterone suggests that drug-induced performance enhancement by hCG or estrogen blockers is highly unlikely.


chorionic gonadotropin
gonadotropin hormone

Human chorionic gonadotropin hcg
Gonadotrophin - human chorionic gonadotropin -  HCG serves to maintain progesterone production by the corpus luteum in the early part of pregnancy. By the time HCG drops at the beginning of the second trimester, the placenta can make sufficient progesterone to maintain the endometrium. HCG also stimulates the development of fetal gonads and synthesis of androgens by the fetal testes. HCG has a similar to function to LH in stimulating secretion of estrogen and development of the placenta.


Gonadotropin Releasing Hormone
GnRH and its analogs (GnRH-a) are used extensively for the treatment of prostate cancer and other hormone-dependent diseases via the desensitization of pituitary gonadotropes, which consequently leads to the inhibition of gonadotropins, gonadal steroids and tumor growth. The actions of GnRH-a are mediated by the GnRH receptor (GnRHR) that is expressed in both the pituitary and extrapituitary sites, including normal tissues and tumors. Several studies have provided evidence that besides its pituitary effects, GnRH-a may exert direct anti-proliferative and apoptotic effects in tumor cells.

 

Gonadotropin emails

Q. I have referred to your site many times because I respect your opinions. I have found some research pertaining to two supplements that you recommend and I'm hoping that you can clarify this information for me. I read from your site that Melatonin has many positive benefits. One of the side effects you state is that "Long term use of Melatonin may have an influence on sex organs." Concerned about this side effect, I did some research and found a UC Berkley Press release that went into clearer, greater detail about the Japanese study you noted. The UC Berkley letter confirmed that melatonin switches on a recently discovered hormone called gonadotropin inhibitory hormone (GnIH), which has the opposite effect of Gonadotropin-releasing hormone (GnRH). Gonadotropin releasing hormone (GnRH) as you may already know, is is a hormone made by the hypothalamus which causes the pituitary gland to make luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Both hormones have direct effect on the growth and maturation of testosterone and sperm in males and eggs in females. It is now demonstrated that melatonin inhibits Gonadotropin releasing hormone (GnRH), which in turn inhibits luteinizing hormone (LH). Does this mean taking melatonin would also
down-regulate the production of testosterone and sperm in males, which in turn would have a negative effect on sex-drive, mood, muscle growth among other things? I have been taking Melatonin on occasion to help me fall asleep, which it works very well. I am very concerned about these side effects.