Hepcidin in blood stream, how to lower levels
November 22 2016

Hemodial Int. 2016. Effects of flaxseed oil on blood hepcidin and hematologic factors in hemodialysis patients. Tabibi H, Mirfatahi M. This study indicates that daily consumption of 6 g flaxseed oil reduces serum hepcidin and improves hematologic factors in hemodialysis patients.

Iron absorption is regulated by circulating hepcidin. Stored samples from a human iron absorption study were used to test the hypothesis that differences in plasma hepcidin explain interindividual variation in iron absorption. Hepcidin-25 concentrations were measured in fasting samples from men recruited to a study investigating the relation between the HFE genotype, iron absorption, and iron status. Log iron absorption was negatively correlated with serum ferritin and with plasma hepcidin but was unaffected by genotype. There was a positive correlation between hepcidin and ferritin. Plasma hepcidin in isolation significantly predicted 36% of the interindividual variation in iron absorption. Plasma hepcidin and serum ferritin concentrations are highly correlated, and, in the normal range of plasma hepcidin values, 36% of interindividual differences in iron absorption are explained by differences in circulating plasma hepcidin.

Trends Pharmacol Sci. 2014 Feb 16. The pathophysiology and pharmacology of hepcidin. Inappropriate production of the iron-regulatory hormone hepcidin contributes to the pathogenesis of common iron disorders. Absolute or relative deficiency of hepcidin causes iron overload in hereditary hemochromatosis and iron-loading anemias. Elevated hepcidin causes iron restriction in inflammatory conditions including autoimmune disease, critical illness, some cancers, and chronic kidney disease. Multiple agents targeting hepcidin and its regulators are under development as novel therapeutics for iron disorders.

Free Radic Biol Med. 2015. Phytoestrogens modulate hepcidin expression by Nrf2: Implications for dietary control of iron absorption. Hepcidin is a liver-derived antimicrobial peptide that regulates iron absorption and is also an integral part of the acute phase response. In a previous report, we found evidence that this peptide could also be induced by toxic heavy metals and xenobiotics, thus broadening its teleological role as a defensin. The ability of phytoestrogens to modulate hepcidin expression in vivo suggests a novel mechanism by which diet may impact iron homeostasis.