product for sleep, relaxation, benefits and side effects by
Ray Sahelian, M.D.
Hops plant (Humulus lupulus) is a native British plant with a stout root, heart-shaped leaves and cone-like flowers. Romans ate the young hops plant shoots in the spring in the same way we do asparagus. The plant was first used by breweries in the Netherlands in the early fourteenth century to make beer. Hops has been used traditionally for nervous disorders and to help anxiety or sleep. Good Night Rx is an all natural alternative medicine and effective herbal product for sleep.
Nature's Way Hops Flowers, 310 mg
Good Night Rx with hops plant extract for deeper sleep, formulated by Ray Sahelian, M.D.
Hops (flower) 310 mg
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Recommendations for hops supplement: Take 1 or 2 hops capsules in the evening. The hops capsules may be opened and placed in a cup with hot water for tea, and lightly sweetened with stevia. They can be taken the same time as Good Night Rx sleeping pill.
I have read that hops extract, 8-np
relieves menopause symptoms. Does this product contain 8-np? If so, then how
much is in it?
Nature's Way company has not tested this substance in this product, so we don't know.
Hops plant benefits
Hops is useful as a sleep inducer, has antioxidant activity, anti-inflammatory, estrogen-like properties, and potential anti-tumor activity. Furthermore, compounds in hops may reduce insulin resistance. Additional nutrients helpful for sleep include melatonin and tryptophan amino acid. 5HTP is a nutrient that helps with relaxation. Passion Flower and kava root extract are herbs that help to calm nerves.
I am looking for documentation on hops helping with reduction of anxiety.
I have not seen studies using hops alone as a treatment for anxiety. This herb is used mostly for sedation as opposed to anxiety treatment.
An interesting study listed below discusses the ability of compounds in hops plant to act as COX-2 inhibitors just like some of the new arthritis drugs Vioxx and Celebrex which may make hops plant a potential therapy in cases of arthritis.
In vitro and ex vivo cyclooxygenase inhibition by a
Asia Pac J Clin Nutr. 2004.
While there has been much research on botanical materials as potential pain-relieving Cox inhibitors, it has not yet been demonstrated that oral consumption of botanical agents can inhibit Cox-2 activity in humans. In particular it would be of interest to determine whether any botanical anti-inflammatory has Cox-1-sparing activity, in order to reduce the risk of gastrointestinal side effects. Seventeen botanical agents, putative anti-inflammatories or pain-relievers all, were evaluated in vitro for Cox-1 and -2 inhibitory potency and selectivity using a caco-2 cell line with ibuprofen as an active control. A promising compound, a hops extract high in alpha acids, showed a Cox-2/Cox-1 IC50 selectivity ratio of 0.06, compared to 4.2 for ibuprofen. Two different formulations of a standardized hops extract (resin and powder) were compared with ibuprofen in a double-blind, randomized, ex vivo study. Subjects consumed hops powder extract, hops resin extract, or ibuprofen, and provided blood samples before and at intervals for 9 h following the first dose. Plasma was extracted and analyzed in a validated Cox-1 and -2 inhibition assay. Results: There were no differences between active treatments or ibuprofen control in Cox-2 inhibitory action, as indicated by 9-hour Cox-2 Area over the Inhibition Curve (AOC); however, hops powder or hops resin extract produced a 9-hour Cox-1 / Cox-2 AOC ratio of about 0.4 (i.e., some degree of Cox-1 sparing), compared to 1.5 for ibuprofen (i.e. no Cox-1 sparing). Hops exhibited Cox-2 inhibition over 9 hours equivalent to ibuprofen 400 mg but had significant Cox-1 sparing activity relative to ibuprofen. Hops extracts may represent a safe alternative to ibuprofen for non-prescription anti-inflammation.
Extracts of several estrogenic herbs, including hops, black cohosh and vitex, inhibit growth of breast cancer cells. These in vitro results suggest that certain herbs and phytoestrogens may have potential in the prevention of breast cancer.
Six flavonoids from hops were tested for their antiproliferative activity in human breast cancer (MCF-7), colon cancer (HT-29) and ovarian cancer. All the hop flavonoids were cytotoxic (cell killing) in the three cell lines. As antiproliferative agents, chalcone and its (flavanone isomer may have potential chemopreventive activity against breast and ovarian cancer in humans.
A potent phytoestrogen in hops, 8-prenylnaringenin, has an activity greater than other established plant estrogens. The estrogenic activity of this compound was reflected in its relative binding affinity to estrogen receptors from rat uteri. The presence of 8-prenylnaringenin in hops may provide an explanation for the accounts of menstrual disturbances in female hop workers. This phytoestrogen can also be detected in beer, but the levels are low and should not pose any cause for concern.
Comparison of the in vitro estrogenic activities of compounds from hops plant (Humulus lupulus) and red clover (Trifolium pratense).
J Agric Food Chem. 2005
Because the prevailing form of hormone replacement therapy is associated with the development of cancer in breast and endometrial tissues, alternatives are needed for the management of menopausal symptoms. Formulations of Trifolium pratense L. (red clover) are being used to alleviate menopause-associated hot flashes but have shown mixed results in clinical trials. The strobiles of Humulus lupulus have been reported to contain the prenylflavanone, 8-prenylnaringenin (8-PN), as the most estrogenic constituent. Extracts of hops and red clover and their individual constituents including 8-PN, 6-prenylnaringenin (6-PN), isoxanthohumol (IX), and xanthohumol (XN) from hops and daidzein, formononetin, biochanin A, and genistein from red clover were compared using a variety of in vitro estrogenic assays. On the basis of these data, hops and red clover could be attractive for the development as herbal dietary supplements to alleviate menopause-associated symptoms.
Sedating effects of Humulus lupulus extracts.
It was the aim of the study to check ethanolic and CO2 extracts from Humulus lupulus for sedating activity. Both preparations reduced the spontaneous locomotor activity, increased the ketamine-induced sleeping time and reduced body temperature, confirming a central sedating effect. No indications of anxiolytic activity were found in the elevated plus maze test for any of the test preparations. This sedating activity could be attributed to three categories of constituents of lipophilic hops extracts. Though the alpha-bitter acids proved to the be most active constituents, the beta-bitter acids and the hop oil clearly contributed to the sedating activity of lipophilic Humulus extracts.
The Fixed Combination of Valerian and Hops (Ze91019) acts via a
Central Adenosine Mechanism.
Planta Med. 2004.
The aim of the study was to demonstrate competition between caffeine and a fixed valerian/ hops extract combination (Ze91019) by the central adenosine mechanism. EEG was used to describe the action of caffeine on the central nervous system after oral administration (200 mg) in healthy volunteers. In addition to caffeine, the volunteers (16 in each group) received either placebo or verum (2 and 6 tablets containing the valerian/ hops extract). The EEG responses were recorded every 30 min thereafter. The valerian/ hops medication was capable of reducing (2 tablets) or inhibiting (6 tablets) the arousal induced by caffeine. This pharmacodynamic action was observed 60 minutes after oral administration, indicating not only competition between the antagonist caffeine and the partial agonist, i. e., the valerian / hops extract but also bio-availability of the compound(s) responsible for the agonistic action. In conclusion, the valerian / hops extract acts via a central adenosine mechanism which is possibly the reason for its sleep-inducing and -maintaining activity.
Is it okay for a man to use hops to help with sleep, seeing that hops
apparently has oestrogen-like properties? I take
Sam-e for depression and it
causes me to have trouble getting a good rest at night.
We don't see any problems using hops by men, after all men drink beer made from hops. Besides, many plants have compounds that have estrogenic properties. SAM-e does cause sleep disturbances, so can ginseng herb and horny goat weed herbal extracts.
theanine help with
anxiety? Can it be taken with hops herb?
L Theanine may be a mild anti-anxiety agent, but we need more human studies to determine if this is true. I don't see any reason why it can't be taken with hops herb.
herb hops and stress hops for anxiety.
When to take hops plant supplement
Due to its sedative effects, hops is best reserved for evening or nighttime.
Hops and beer
Side effects, safety
No major side effects have been reported in medical studies.
Comparative study for assessing quality of life of patients with exogenous sleep disorders (temporary sleep onset and sleep interruption disorders) treated with a hops-valarian preparation and a benzodiazepine drug
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