Iberogast supplement by Ray Sahelian, M.D.

Iberogast is a fixed combination of several medicinal herbal extracts for the treatment of functional dyspepsia and irritable bowel syndrome. It is also known as STW 5.

Herbs found in Iberogast
Proprietary blend of the following herbal extracts: German chamomile (Matricaria recutita) flower, clowns mustard (Iberis amara) plant, angelica (Angelica archangelica) root and rhizome, caraway (Carum carvi) fruit, milk thistle (Silybum marianum) fruit, lemon balm (Melissa officinalis) leaf, celandine (Chelidonium majus) aerial part, licorice (Glycyrrhiza glabra) root, and peppermint (Mentha x piperita) leaf.

Iberogast for functional dyspepsia
STW 5, a phytopharmacon for patients with functional dyspepsia: results of a multicenter, placebo-controlled double-blind study.
Am J Gastroenterol. 2007 Jun;102(6):1268-75. von Arnim U, Peitz U, Vinson B, Gundermann KJ, Malfertheiner P.
Otto-von-Guericke-Universität Magdeburg, Zentrum für Innere Medizin, 39120 Magdeburg, Germany.
Functional dyspepsia constitutes a complex picture with a variety of epigastric symptoms. This multicenter, placebo-controlled, double-blind study evaluated the efficacy and tolerability of the herbal drug STW 5, mainly comprising a fresh plant extract from Iberis amara. A total of 315 patients were treated with 3 x 20 drops/day of either STW 5 or placebo, of them 158 were treated with STW 5 and 157 with placebo. Gastrointestinal Symptom Score showed improvement during the treatment period. The STW 5 group improved 6.9 points up to day 56, placebo group by 5.9. H. pylori did not influence the results. This placebo-controlled study with an 8-wk treatment period documents the efficacy of STW 5 in functional dyspepsia.

Effect of Iberogast on smooth muscles
Spasmolytic and tonic effect of Iberogast (STW 5) in intestinal smooth muscle.
Phytomedicine. 2006;13 Suppl 5:67-74. Epub 2006 Sep. Department of Pharmacology, Institute of Pharmaceutical Sciences, University of Tübingen, 72076 Tübingen, Germany.
The effects of Iberogast, a combination of Iberis amara fresh plant extract, and other eight plant extracts as well as single extract components including extracts from Menthae piperitae folium, Matricariae flos and Liquiritiae radix, were assayed in guinea pig ileum with or without stimulation with acetylcholine or histamine, in order to find a possible effect on the contractility of intestinal smooth muscle. Iberogast decreased acetylcholine- and histamine-induced contraction of guinea pig ileum. This was also true for extracts of Menthae piperitae folium, Matricariae flos and L. radix. Extract from Iberia amara, however, showed no spasmolytic action; in contrary, it increased the basal resting tone and contraction of atonic ileal segments. This was also true when Iberogast was employed. A spasmolytic action of Iberogast could also be observed in duodenum, jejunum and colon. These data are the first to show not only the spasmolytic effects of Iberogast and its component extracts in intestinal muscle but also the tonicising effects of Iberogast through its component Iberis amara extract in relaxed intestinal muscle. Thus, pharmacological evidence suggests a dual-action principle and may explain, at least in part, the clinically observed therapeutic efficacy of Iberogast in both hypotonic and spastic dysmotility symptoms of functional dyspepsia and irritable bowel syndrome.

Iberogast questions
Q. I was just browsing through your site looking for information on Iberogast. I read your article on IBS and was wondering if it would be worthwhile to mention Iberogast as being an option. I do not suffer from IBS, but someone close to me does, hence my online investigation.
   A. After briefly reviewing the research on Iberogast, it appears that some early studies look promising. However, I don't have clinical experience with it so I have no first hand knowledge whether it is effective for IBS.