Juvenon supplement information
Feb 22 2014 by
Ray Sahelian, M.D.

On the Juvenon website, it is claimed that "... a team of scientists discovered... by combining a natural, energy-boosting component (acetyl L-carnitine) with a powerful anti-oxidant (alpha lipoic acid) they could slow the cell aging process. The result is Juvenon, a patented cellular health supplement." Each Juvenon tablet contains 500 mg of acetyl l carnitine, 200 mg of alpha lipoic acid, 100 mcg of biotin, and 77 mg of calcium. The Juvenon website recommends 2 tablets a day.

As of February 2014 no studies could be found on Medline.

Questions
Q. I have read all the research at the Juvenon dot com website and was wondering what your thoughts on this supplement are? Juvenon was formulated and researched by Dr. Bruce Ames and is recommended by Dr. Andrew Weil. Both are fairly well known and educated on the subject But I would like to know how you felt about this Juvenon supplement? Is it dangerous to take? Is Juvenon a beneficial addition to my current supplement regimen? I currently only take a multi-vitamin / multi-mineral, fish oil capsules and saw palmetto. I also occasionally drink noni or goji or pomegranate juice as well.
   A. I have not seen any specific research in humans with Juvenon. However there have been many studies with the ingredients in Juvenon, specifically acetyl l carnitine and alpha lipoic acid. In my opinion, the amount of acetyl l carnitine and alpha lipoic acid are excessive and could lead to overstimulation and insomnia. Lack of deep sleep could speed the aging process, therefore, my opinion is that the current recommendation of 2 tablets a day of Juvenon may speed the aging process. Perhaps a tiny fraction of Juvenon could be beneficial.

Q. Dr. Andrew Weil said he takes a supplement Juvenon, I looked it up on google and it looked like it was a combination of alpha lipoic acid and acetyl L-carnitine. You have said in your newsletters that you don't recommend taking high doses of ALA or even taking it everyday. Juvenon has 200 mg of ALA and Dr. Weil recommends you take it twice a day with food. I tend to agree with you the less is more and you don't have to take high doses of certain supplements so I wanted to run this buy you and ask if you have even heard of Juvenon.
   A. Since research wit nutritional supplements is not extensive, there are a number of opinions regarding the best supplements to take for long term health. Different doctors and scientists are likely to have different viewpoints including dosage. In my personal experience, high dosages of ALA and acetylcarnitine can cause insomnia and ALA may cause heart rhythm disturbances. Until we know more about the long term side effects of these supplements, I prefer to take low dosages and take days off. I respect Dr. Andrew Weil and obviously he thinks it is healthy to take Juvenon at these high dosages. We just have different viewpoints on this topic.

Q. I enjoy your newsletter. I notice that you are conservative when it comes to alpha lipoic acid. Juvenon website recommends 400 mg alpha lipoic acid a day along with 1,000 mg of acetyl-l-carnitine for stimulating the mitochrondia. Dr. Weil also touts the Juvenon formula. Do you have any evidence to base your position that these high dosages will not necessarily lead to a longer life or improved health?
   A. When a doctor or scientist or a supplement marketer promotes or recommends high dosages of a supplement or a combination of supplements with the promises of improved health and longevity, it is their responsibility to provide such evidence of health improvement rather than the responsibility of another doctor or researcher to provide contrary evidence or to suggest being cautious. As of December 2008, I have not seen any human studies that taking Juvenon or high dosages of acetyl l carnitine or alpha lipoic acid prolongs lifespan. In fact, in my experience, high dosages of alpha lipoic acid and acetyl l carnitine can disrupt sleep and ALA may even cause heart rhythm disturbances. If evidence is provided to me that taking several hundred milligrams of a combination of ALA and aceytl l carntine for months or years provides health benefits, then I will reconsider my current viewpoint.

Do you have any updated ideas on Juvenon. I was considering it until I read your thoughts on dosage and possible cardiac arrhythmia. I take meds for atrial fib.
    As of January 2010, I have not seen any specific studies with this dietary supplement. I still think it is a beneficial product but, in my opinion, should be used in low dosages.