Kaempferia parviflora Krachaidum by Ray Sahelian, M.D.
February 14 2014

Kaempferia parviflora has been used in Thailand for medicinal purposes. It is of the ginger family and grows in Thailand. It is also known as black galingale, Krachaidam, Krachaidum or Kra chai dam or even  Krachai dam. If you are interested in an effective sexual enhancing pill formulated by Dr. Sahelian, consider the highly popular Passion Rx.

Kaempferia Parviflora benefits
This plant may have anti-malaria and anti- fungal properties along with sexual enhancement.

Eur J Pharmacol. 2012. Relaxant mechanisms of 3, 5, 7, 3', 4'-pentamethoxyflavone on isolated human cavernosum. Department of Physiology, Faculty of Science, Prince of Songkla University, Songkhla, Thailand. We have investigated effects and mechanisms responsible for the activity of 3, 5, 7, 3', 4'-pentamethoxyflavone (PMF) on isolated human cavernosum. PMF is the major flavone isolated from Kaempferia parviflora claimed to act as an aphrodisiac. PMF caused relaxation of phenylephrine precontracted human cavernosal strips, and this effect was slightly inhibited by N(G)-nitro-l-arginine, a nitric oxide synthase inhibitor, but not by ODQ (soluble guanylate cyclase inhibitor), TEA (tetraethylammonium, blocker of voltage-dependent K(+) channels) or glybenclamide (blocker of ATP-dependent K(+) channels). These studies suggest that PMF causes relaxation of human cavernosum through voltage-dependent Ca(2+) channels and other mechanisms associated with calcium mobilization.

Kaempferia parviflora as an aphrodisiac
J Ethnopharmacol. 2011. Kaempferia parviflora, a plant used in traditional medicine to enhance sexual performance contains large amounts of low affinity PDE5 inhibitors. Kaempferia parviflora rhizome extract and its 7-methoxyflavone constituents had moderate inhibitory activity against PDE5. This finding provides an explanation for enhancing sexual performance in the traditional use of Kaempferia parviflora. Moreover, 5,7-dimethoxyflavones should make a useful lead compound to further develop clinically efficacious PDE5 inhibitors.

Effects of Kaempferia parviflora extracts on reproductive parameters and spermatic blood flow in male rats.
Reproduction. 2008. Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand.
Krachaidum (Kaempferia parviflora, a native plant of Southeast Asia, is traditionally used to enhance male sexual function. However, only few scientific data in support of this anecdote have been reported. The present study investigated the effects of feeding three different extracts of Kaempferia parviflora (alcohol, hexane, and water extracts) for 3-5 weeks on the reproductive organs, the aphrodisiac activity, fertility, sperm motility, and blood flow to the testis of male rats. Our results indicate that alcohol extract of Kaempferia parviflora had an aphrodisiac activity probably via a marked increase in blood flow to the testis.

Prostate gland
Pharmacognosy Res. 2013 Oct. Suppression of benign prostate hyperplasia by Kaempferia parviflora rhizome.

Kaempferia Parviflora side effects
Kaempferia has mild side effects which include underarm sweating and increased body temperature. More serious side effects on high doses include heart beat speeding and arrhythmia or irregular heart rhythm. This limits the usefulness of this herb in high doses.

Indian J Med Res. 2013. Effects of Kaempferia parviflora on electrophysiology of the swine hearts. Department of Physiology & Cardiac Electrophysiology Research & Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. The underlying assumption is that in the heart, KP might be producing effects similar to sildenafil citrate as KP has long been used in southeast Asian traditional medicine to correct erectile dysfunction. The study was conducted as the defibrillation study, and ventricular fibrillation (VF) induction study. KP extract at high concentrations (100 and 50 mg/kg) increased cardiac vulnerability to arrhythmia in a normal swine heart. When used in appropriate concentrations, its blood pressure lowering effect may be useful in hypertensive states.

Research studies
Bioactive flavonoids from Kaempferia parviflora.
Fitoterapia. 2004. Faculty of Sciences, Khon Kaen University, Khon Kaen  Thailand.
Nine flavonoids have been isolated from Kaempferia parviflora. Among these, 5,7,4'-trimethoxyflavone and 5,7,3',4'-tetramethoxyflavone exhibited antiplasmodial activity against Plasmodium falciparum. 3,5,7,4'-Tetramethoxyflavone and compound 8 possessed antifungal activity against Candida albicans, and also showed mild antimycobacterial activity.