Lexapro by Ray Sahelian, M.D. Escitalopram

Lexapro is prescribed for major depression. To be considered major, depression must occur nearly every day for at least two weeks, and must include at least five of the following symptoms: low mood, loss of interest in usual activities, significant change in weight or appetite, change in sleep patterns, agitation or lethargy, fatigue, feelings of guilt or worthlessness, slowed thinking or lack of concentration, and thoughts of suicide.
     Escitalopram (Cipralex), Lexapro), the active S-enantiomer of the racemic SSRI citalopram (RS-citalopram), is a highly selective inhibitor of the serotonin transporter protein. It possesses a rapid onset of antidepressant activity, and is a treatment for moderate-to-severe major depressive disorder.

Lexapro side effects
The rate of a Lexapro side effect is higher in patients who take 20 mg as opposed to those who use 10 mg. A common Lexapro side effect is nausea which can occur in one of out five Lexapro users. Another common Lexapro side effect is insomnia. Not getting enough sleep can actually make depression worse. Additional Lexapro side effects that are possible include problems with ejaculation, increased sweating, fatigue, decreased libido, and difficulty with orgasm. The sexual side effect of Lexapro is quite bothersome to many users. We have had reports of fatigue as a common Lexapro side effect. Those who are depressed do not appreciate being fatigued.

How does Lexapro work?
Lexapro works by boosting levels of serotonin, one of the chief chemical messengers in the brain. Lexapro is a close chemical cousin of the antidepressant medication Celexa. Other antidepressants that work by raising serotonin levels include Paxil, Prozac, and Zoloft.

Lexapro maintenance treatment

Maintenance therapy with the antidepressant Lexapro reduces the risk for recurrent depression. Dr. Susan G. Kornstein from Virginia Commonwealth University, Richmond, investigated the preventive effect of Lexapro maintenance treatment in 139 patients who had responded to treatment with another similar antidepressant and maintained that response when switched to Lexapro for continuation therapy. Some patients with a major depressive episode need acute phase treatment to get their symptoms into remission, followed by continuation phase treatment to prevent that episode from returning (which would be called a relapse). Time to recurrence of depression in the current study was significantly longer for Lexapro-treated patients -- on average 252 days with Lexapro versus 130 days with placebo. It is possible that other SSRI antidepressants or natural supplements could be as effective as Lexapro for maintenance treatment. Journal of Clinical Psychiatry, November 2006.

Lexapro and Generic Lexapro

July of 2006 - shares of Forest Laboratories Inc. surged after a U.S. court upheld a key patent for its blockbuster anti-depressant Lexapro. Analysts said Forest's victory over generic drug maker Teva Pharmaceutical Industries Ltd., wiped away a major cloud hanging over the stock.

Escitalopram (brand names Lexapro, Cipralex, Sipralexa and Seroplex) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Escitalpram is approved for the treatment of major depressive disorder and generalized anxiety disorder.

Lexapro Questions
Q. I have a question about Lexapro side effects. Is difficulty with orgasm a Lexapro side effect? My doctor didn't tell me about this when he started me on the medicine.
   A. Yes, difficulty with orgasm is a Lexapro side effect, so is reduced libido and sensation of genital organs.
 

Q. Does Lexapro cause weight gain?
   A. Although the company making Lexapro does not list weight gain as a prominent side effect, many users have noticed weight gain after taking Lexapro. At this time I'll wait for more observations or studies before making a definite comment about the association between Lexapro and weight gain.
 

Q. I have Hepatitis C and five years ago I underwent treatment for this condition. The medication caused me to experience severe depression and was placed on Lexapro antidepressant. I had never been diagnosed with depression before. I recently got off Lexapro and I'm experiencing some mood changes and impulsive problems...question: can 5-HTP help me? I don't ever want to go back to antidepressants again, and Lexapro never really did anything for me, except get dependent on it.
   A. It is impossible to predict how a supplement will make you feel and whether it can replace the Lexapro without trying it. So, if you plan to take 5-HTP, do inform your doctor.
 

Q. I have just started on Sam-e to treat depression and am starting out very slow. Perhaps 100mg every other day? II was formally on Lexapro for anxiety primarily but I really don’t like the side effects (weight gain and tiredness). 
   A. Each person needs to find the dosage that works for them best. For some it is 100 mg every other day or every third day, for others it is 200 mg a day. The only way to tell is by trial and error.
 

Q. I'm taking Lexapro, can i take fish oil? Maybe i will stop taking this Lexapro (because of side effects) and start taking 5htp, can i take fish oil with 5htp? i became worried when i read this: "As with other psychotropic drugs that interfere with serotonin reuptake, patients should be cautioned regarding the risk of bleeding associated with the concomitant use of Lexapro with NSAIDs, aspirin, or other drugs that affect coagulation. Before you begin taking Lexapro, make sure to tell your healthcare professional if you are taking any other medicines, including over-the-counter medicines, herbal remedies, diet supplements, etc."
   A. Usually one or two fish oil capsules are safe with practically any medicine or herbal supplement, however we can't make that decision for you, it is something you would discuss with your doctor.

Q. I am in Cipralex since 5 months, I developed moderate sleep apnea and hypopnea since 2 months. I think Cipralex is cause of this sleep apnea?
   A. Lexapro can cause sleep disturbances.
 

Q. Can a Lexapro withdrawal symptom be hypertension when I have never had a history of hypertension. I weaned off slowly, but even after a month, I'm still getting the brain zaps and now hypertension.
   A. We don't have enough experience with Lexapro withdrawal to know whether persisitent hypertension is a side effect.

Q. I recently ordered your Passion Rx. I currently take 10 mg of Lexapo per day and noticed that the label stated not to the Passion Rx on the same day as the anti-depression medication.

Q. I am purchasing Passion Rx because Cialis only creates an erection without feeling and no orgasm. Will Passion Rx allow orgasm and will it interfere with my daily dose of 10mg of Lexapro? If so, how can I work around this?
   A. Lexapro side effects occur more frequently in patients who take 20 mg as opposed to those who use 10 mg. Lexapro works by boosting serotonin levels which can inhibit sexual urge and sensation and make erections more difficult. We prefer Passion Rx not be used the same day as Lexapro. As a general rule, Passion Rx is taken at most 3 days a week. If you doctor agrees for you to be off Lexapro on certain days where you take Passion Rx, that would be a good option. However, your doctor may agree for you to take a third of a capsule of Passion Rx on the days you take Lexapro, but perhaps the dose of the Lexapro can be reduced on those days. It may be more difficult for any sexual enhancement product to be effective when a SSRI drug such as Lexapro or Prozac is used due to the serotonin influence. Once the effects of Passion Rx begin to work, they can last several days. We don't suggest using Passion Rx the same day as Cialis. These are general guidelines that your doctor can use to guide you further.

Q. My doctor just prescribed Lexapro ( which is an anti-depressant ) for anxiety. would it be ok for me to use SAM e instead? Also i know that you can not drink with antidepressants, but will alcohol effect SAM e the same way? Can SAM e and Lexapro be taken together?
   A. SAM-e is a powerful antidepressant and should be used with caution. We cannot advise you what treatment options to choose. SAM-e, in high dosages, can cause anxiety and a manic phase. We don't suggest having more than an ounce or two of wine with SAM e. And, Lexapro and SAM-e should not be taken together unless in tiny dosages and supervised by a doctor who is familiar with this combination.

Q. i have a question I'm on Lexapro and i gain allot of weight and i'm trying to loss weight can you help me?
   A. Perhaps you can review the information listed at weight loss page.