Lobelia herb is a common weed that grows wild in North America. Lobelia herb has been recommended for asthma treatment although I cannot find any specific research. Much still needs to be learned regarding the use of lobelia before it can be widely consumed as a medicinal herb.
How is Lobelia available?
Lobelia herb extract is sold over the counter in health food stores or the
internet. Most commonly lobelia is available as a 4 to 1 extract. You can also
find lobelia as a bulk powder.
Lobelia Plant
There are many varieties of lobelia plant. Many species are grown in English
gardens since the lobelia flower is quite attractive. Lobelia flower comes in
shades of scarlet, purple, and blue lobelia.
Lobelia cardinalis
Lobelia Dortmanna grows in England
Lobelia erinus
Lobelia inflata - Lobeline (alpha-lobeline) is a lipophilic, nonpyridine,
naturally occurring alkaloid obtained from Indian tobacco, Lobelia inflata.
lobeline inhibits catecholamine secretion evoked by stimulation of cholinergic
(both nicotinic and muscarinic) receptors.
Lobelia laxiflora plant
Lobelia Urens grows in the UK
Lobelia Herb Research
A novel mechanism of action and potential use for
lobeline as a treatment for psychostimulant abuse.
Biochem Pharmacol. 2002 Jan 15;63(2):89-98. Dwoskin LP, Crooks PA.College of
Pharmacy, University of Kentucky, Lexington, KY
Lobeline, an alkaloidal constituent of Lobelia inflata LINN., has a long history
of therapeutic usage ranging from emetic and respiratory stimulant to tobacco
smoking cessation agent. Although classified as both an agonist and an
antagonist at nicotinic receptors, lobeline has no structural resemblance to
nicotine, and structure--function relationships do not suggest a common
pharmacophore. Lobeline inhibits nicotine-evoked dopamine release and
[3H]nicotine binding, thus acting as a potent antagonist at both alpha3beta2(*)
and alpha4beta2(*) neuronal nicotinic receptor subtypes. However, lobeline does
not release dopamine from its presynaptic terminal, but appears to induce the
metabolism of dopamine intraneuronally. Reevaluation of the mechanism by which
lobeline alters dopamine function reveals that its primary mechanism is
inhibition of dopamine uptake and promotion of dopamine release from the storage
vesicles within the presynaptic terminal, via an interaction with the
tetrabenazine-binding site on the vesicular monoamine transporter (VMAT2). Thus,
lobeline appears to perturb the fundamental mechanisms of dopamine storage and
release. Based on its neurochemical mechanism, the ability of lobeline to
functionally antagonize the neurochemical and behavioral effects of the
psychostimulants amphetamine and methamphetamine was examined. Lobeline was
found to inhibit the amphetamine-induced release of dopamine in vitro, and
amphetamine-induced hyperactivity, drug discrimination, and self-administration.
However, lobeline does not support self-administration in rats, suggesting a
lack of addiction liability. Thus, lobeline may reduce the abuse liability of
these psychostimulants.
Phytochemical study and antiinflammatory properties of
Lobelia laxiflora plant.
Z Naturforsch [C]. 1998 May-Jun;53(5-6):311-7.
Three new piperidine alkaloids were isolated from stems, leaves and flowers
of Lobelia laxiflora L. (Campanulaceae). The structures of racem.
cis-8,10-diethyl-3,4-dehydrolobelidiol (1), racem.
trans-8-ethyl-10-phenyl-3,4-dehydrolobelidiol (2) and racem.
cis-8-ethyl-10-phenyl-3, 4-dehydrolobelidiol (3) were established by spectral
analyses. The ability of the residues, nonalkaloid fractions, alkaloid fractions
and the three alkaloids at a concentration from 0.125 to 1.0 mg ml-1 to inhibit
complement activation and thus to prevent inflammatory process was estimated in
vitro in human serum via both pathways. All of them inhibited complement
activity with a predominant action on CP.
Pharmacological properties of beta-amyrin palmitate, a
novel centrally acting compound, isolated from Lobelia inflata leaves.
J Pharm Pharmacol. 1993 Jun;45(6):545-50.
Effects of beta-amyrin palmitate isolated from the leaves of Lobelia inflata
were studied on the central nervous system of mice and were compared with those
of antidepressant drugs, mianserin and imipramine. In the forced swimming test,
beta-amyrin palmitate, like mianserin and imipramine, reduced the duration of
immobility of mice significantly in a dose-dependent manner. These results
suggest that beta-amyrin palmitate has similar properties in some respects to
mianserin and might possess a sedative action.
Other species of lobelia flower or lobelia plant
include lobelia cardinalis, lobelia erinus,
lobelia siphilitica, lobelia chinensis
Lobelia Questions
Q. Can lobelia be used with sex products and herbs such as maca, hormy goat
weed, catuaba, or yohimbe?
A. Caution is advised when using lobelia with
supplements that have a stimulatory nature.