Longevity Research Center, newsletter, alternative methods to a longer life, longevity enhancing supplements
May 18 2017
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newsletter at Physician Formulas by renowned author and medical doctor Ray Sahelian, M.D.

How to live longer
The field of longevity and anti-aging is full of promises and unsubstantiated claims. As of now, there is no definitive research in humans of any substances or techniques that have been proven to extend longevity. However, there are a number of steps we can take to potentially live longer. These include:

Longevity enhancers
1. Have a positive attitude and improve your coping skills to daily stresses. Embrace the philosophy that "It's not what happens to me, it's what I make of it." In a sample of people aged 50 and older who were followed for an average of 23 years, respondents who reported having a positive attitude toward aging lived an average of more than 7 years longer than those who had a more dismal view of getting older. Do you want to be happier? Take a look at my book on Happiness.

2. Keep a healthy weight and reduce the number of calories consumed. Caloric restriction prolongs life in animals. Cutting calories may do more than help people shed excess weight, research suggests. According to a new report, a low-calorie diet may also slow age-related changes in the heart's genes that can lead to chronic disease. In the study, "middle-aged" 14-month-old mice were fed either a normal diet or one restricted in calories. When the mice reached 30 months of age, or the equivalent of 90 years of a human life span, the researchers analyzed their heart tissue. The hearts of mice on the low-calorie diets showed nearly 20% fewer age-related genetic changes and also appeared to have less DNA damage than those of mice on regular diets. Restricting calories also inhibited potentially disease-causing changes in the immune system, and suppressed apoptosis, or programmed cell death.
   Polyunsaturated fats are found in fatty fish (such as salmon, herring, mackerel and trout), soybeans, tofu, soybean oil, corn oil, sunflower oils and seeds, and walnuts. These fats help lower bad cholesterol, and have been linked to a lower risk of heart disease and stroke, and increased lifespan.

   
Mouse study: eating less at any age prolongs life.
   Overweight middle-aged men may have a higher risk of heart problems and strokes and die earlier than their thinner peers. Circulation, online December 28, 2009. However, a few extra pounds might help you live longer if you're past your prime but otherwise healthy. Journal of the American Geriatrics Society, 2010.  

Comprehensive lifestyle changes comprising: a low-fat Vegan diet, stress management, moderate aerobic exercise, significantly increase telomerase activity and consequently telomere maintenance capacity in human immune-system cells.

A 20-year study of monkeys shows that a reduced-calorie diet pays off in less disease and longer life. Rhesus monkeys on a strict, reduced-calorie diet were three times less likely to die from age-related diseases like heart disease, cancer and diabetes over the study period than monkeys that ate as they liked. Science, July 10, 2009.

3. Reduce consumption of foods cooked at high temperature which may lead to acrylamide formation. Drink more tea, particularly green tea.

4. Regular exercise and keep physically active. Regular stretching or yoga is helpful in keeping joints and ligaments supple.
    Old people who are physically active are apt to live longer than their couch-potato peers, and are more likely to maintain their independence. Archives of Internal Medicine, September 14, 2009.
    Sitting in front of a television set for hour after hour day after day may raise the risk of death from heart disease and other causes - even in people who do not weigh too much.
   The more muscle older adults have, the lower their risk of death.
   People who get either no exercise or high-mileage runners both tend to have shorter lifespans than moderate runners.

5. Avoid smoking cigarettes. Smokers die ten years younger on average than non-smokers
As if smokers need another reason to kick the habit, California scientists have discovered that nornicotine, a byproduct of nicotine, the substance that makes cigarettes so addictive, causes a type of chemical reaction in the body similar to that which occurs when sugar is scorched or food goes bad. This reaction is thought to play a role in diabetes, cancer and other diseases. The interaction between sugars and proteins can produce substances called advanced glycation end products, or AGEs. The accumulation of AGEs appears to contribute to the aging process and certain diseases.

6. Have strong connections to others, whether through family and relatives, marriage, children, pets, or connecting with nature, planet earth, and the universe.

Arguing and worrying over family problems leads to an increased risk of dying in middle age. Conflicts with family, friends and neighbors pose the greatest risk. Those most at risk are men and people out of work.

7. Get a deep sleep, one of the most important ways to improve health.

8. Keep your mind young and active by learning.
   People who have greater intellectual ability as children have fewer heart disease risk factors in middle-age. A number of studies have linked higher childhood IQ to better adulthood health and a longer life. Early environment -- starting in the womb -- may affect both a child's intellectual ability and long-term disease risks. On the other hand, childhood ability also affects a person's chances of getting a good job or adopting a healthy lifestyle in adulthood. Childhood intelligence indirectly affects long-term heart health -- mostly by influencing a person's education, job and health habits in adulthood. American Journal of Public Health 2009.
   The more bored you are, the more likely you are to die early. Annie Britton and Martin Shipley of University College London caution that boredom alone isn't likely to kill you — but it could be a symptom of other risky behavior like drinking, smoking, taking drugs or having a psychological problem.
   It is well known that people with poorer education and lower incomes often face higher risks of ill health and a range of diseases. Studies have pointed to many likely reasons, including limited access to healthcare and other resources, poorer living conditions, chronic stress and higher rates of lifestyle risk factors like smoking.

9. Try to surround yourself with nature. Green trees in the neighborhood, sunshine in the home, are linked to longevity.

10. Have loving and caring friends. Research suggests that having a strong network of friends helps people live longer.

Have work that you enjoy and has flexible schedules. People who have some control over their work schedules enjoy better physical and mental well-being than those in less-flexible jobs. Cochrane Database of Systematic Reviews, online February 17, 2010.

Use of dietary and nutritional supplements
Mice fed a supplement containing 30 dietary ingredients did not experience a 50 per cent loss in daily movement like other non-supplemented animals. The benefits were linked to increases in the activity of mitochondria as well as by reducing levels of free radicals produced by the mitochondria. David Rollo, from McMaster University, says, “This study obtained a truly remarkable extension of physical function in old mice, far greater than the respectable extension of longevity that we previous documented. This holds great promise for extending the quality of life of ‘health span’ of humans.” David Rollo says that it is not known if the effects would be repeated in humans and years of clinical trials would be necessary before any firm conclusions could be drawn. The supplement was composed of vitamins B1, B3 (niacin), B6, B12, C, D, E, folic acid, beta-carotene, CoQ10, rutin, bioflavonoids, ginko biloba, ginseng, green tea extract, ginger root extract, garlic, L-Glutathione, magnesium, selenium, potassium, manganese, chromium picolinate, acetyl L-carnitine, melatonin, alpha-lipoic acid, N-acetyl cysteine, acetylsalicylic acid, cod liver oil, and flax seed oil. The study was funded by the Natural Sciences and Engineering Research Council of Canada. Experimental Biology and Medicine 2010, Vol. 235, “Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging.”

Carnosine could be of benefit
Maturitas. 2016. Carnosine and the processes of ageing. Carnosine's possible anti-aging mechanisms are therefore discussed; the evidence suggests that inhibition of the mechanistic target of rapamycin and carbonyl scavenging may be involved.

Ageing Res Rev. 2013. Vitamin E supplementation and lifespan in model organisms. The findings of our literature review suggest that there is no consistent beneficial effect of vitamin E on lifespan in model organisms which is consistent with reports in human intervention studies.

Total mortality risk in relation to use of less-common dietary supplements
Am J Clin Nutr 2010;
Dietary supplement use is common in older US adults; however, data on health risks and benefits are lacking for a number of supplements. We evaluated whether 10-y average intakes of 13 vitamin and mineral supplements and glucosamine, chondroitin, saw palmetto, Ginko biloba, garlic, fish-oil, and fiber supplements were associated with total mortality. We conducted a prospective cohort study of Washington State residents aged 50–76 y during 2000–2002. Participants (n = 77,719) were followed for mortality for an average of 5 y. None of the vitamin or mineral 10-y average intakes were associated with total mortality. Among the nonvitamin-nonmineral supplements, only glucosamine and chondroitin were associated with total mortality. For most of the supplements we examined, there was no association with total mortality.

Can you tell me your opinion on Jou Longevity - Dietary Supplement. The ingredients are  Dodder Seed, Mulberry Fruit, Organic Rehmannia, Organic Cornus Fruit, Organic Dodder seeds, Medicated leaven, Organic Orange peel, Organic Wolfberry fruit, Organic Yam, Organic Poria, Organic Achyranthis root, Organic Dendrobium, Organic Wild asparagus root, Organic Solomon’s seal root, Organic Mulberry fruit, Organic Privet fruit.
   I like the ingredients in there but not knowing the dosages and how this formula influences long term health it is difficult to know whether it has anti aging potential. One option is to take one capsule once or twice a week.

High Blood Pressure and Longevity
High blood pressure can take years off both life expectancy and time lived free of disease. Research, based on data from a long-running U.S. heart-health study, found that the impact of high blood pressure on life expectancy may be more significant than previously estimated. Researchers found that high blood pressure at the age of 50 shaved about 5 years off men's and women's lives. It also caused them to endure 7 more years with cardiovascular disease compared with their peers who had normal blood pressure in middle-age. It's well known that high blood pressure raises the risk of heart disease, stroke and kidney failure, but only a few studies have looked at how blood pressure affects longevity.

Ovary Removal and Longevity
Women who undergo removal of both ovaries before the age of 45 years have decreased longevity if they do not receive estrogen replacement treatment up to the age of 45 years.

Centenarians
In a survey of people between the ages of 100 and 104, 23 percent said faith rather than genes and good medical care were responsible for their long life. Other factors given included hard work, a healthy diet and "living a good, clean life." Sixty-one percent of those surveyed said there was nothing they would have done more of in their lives and 78 percent said there is nothing they would have done less. About 13 percent said they wished they had traveled more, 9 percent said they wished they had worked less and 6 percent said they wished they had spent more time with their families. The survey, conducted by Evercare which provide health plans to the disabled and chronically ill, indicated that 30 percent of centenarians considered raising a family as their most satisfying achievement while 20 percent valued mostly their careers.

Children of centenarians
People who make it to the age of 100 have some "good genes" that they pass on their children. A study of more than 600 older U.S. adults found that the children of centenarians tended to live longer and were substantially less likely to develop diabetes or suffer a heart attack or stroke. Journal of the American Geriatrics Society, November 2008.

We are no longer publishing our Longevity Research Update newsletter but instead we are emailing a monthly supplement research update newsletter.

2014 - Americans are living longer than ever and their life expectancy is increasing every year. People born in 2009 can expect to live 78.5 years. That's an increase from just a year before (when life expectancy at birth was 78.1 years). Since these data were collected, life expectancy has increased even more, according to the U.S. Centers for Disease Control and Prevention website, and now stands at 78.7 years.

2014 report - Average life expectancy in the United States reached an all-time high of 78.8 years in 2012.

In a 2007 study by the Census Bureau, Andorra, a tiny country in the Pyrenees mountains between France and Spain, had the longest life expectancy, at 83.5 years, followed by Japan, Macau, San Marino and Singapore. The shortest life expectancies were in Sub-Saharan Africa, a region that has been hit hard by an epidemic of HIV and AIDS, as well as famine and civil war. Swaziland has the shortest, at 34 years, followed by Zambia, Angola, Liberia and Zimbabwe.

Longevity research - Four basic longevity enhancers
People who drink moderately, exercise, quit smoking and eat five servings of fruit and vegetables each day live on average 14 years longer than people who adopt none of these behaviors.

Longevity statistics
2017
Andorra, located between France and Spain has the world's longest life expectancy at 84.8 years. Iceland has the next highest life expectancy at 83.3 years.

2016
For the first time since 1993, life expectancy in the United States has dropped significantly for the entire population, not just certain groups. On average, Americans can now expect to live 78.8 years, according to a Centers for Disease Control and Prevention report released in December 2016, a statistically significant drop of 0.1 year from last year. Though this doesn't sound like much, it may foreshadow a larger dip to come, or it may prove to be a blip reversed when the 2016 numbers are released next December.

The United States lags behind other advanced nations when it comes to infant mortality and the life expectancy of its citizens, according to a comprehensive review of global health statistics. The health of U.S. citizens is specifically challenged by smoking, diabetes, high blood pressure, drug abuse and gun violence.

Japanese women have held the record for the world's longest life expectancy for 25 years in a row, with an average life span of 86.4 years as of 2009. Life expectancy in Japan rose for the fourth straight year in 2009. Japanese men, on average, had a life expectancy of 79.6 years, the fifth longest in the world.

Longevity research studies
Chronic psychological stress is associated with accelerated shortening of the caps, called telomeres, on the ends of chromosomes in white blood cells -- and thus hasten their demise -- according to a report in the Proceedings of the National Academy of Sciences. Telomeres promote chromosome stability. Telomeres shorten with each replication of the cell, and cells cease dividing when telomeres shorten sufficiently. The team investigated the theory that psychological stress affects telomere shortening and thereby contributes to a decrease in longevity. Their study included 39 healthy, premenopausal women who were primary caregivers for a child with a chronic illness, and 19 age-matched mothers of healthy children who served as a comparison "control" group. Stress was measured with a standardized questionnaire, and telomere length was measured in participants' blood samples. Within the caregiving group, the longer that a woman had been a caregiver, the shorter was the length of telomeres. In the 14 women with the highest stress scores, telomeres averaged 3,110 units in length; the 14 with the lowest stress had telomeres that averaged 3,660 units. In adults, telomeres shorten by an average of 31 to 63 units per year, so the scientists estimate that the 550-unit shortening in the high-stress group translates to 9 to 17 additional years of aging.

The compound that makes red wine a healthful drink may also hold one of the secrets to longevity. Researchers found that resveratrol acted on fruit flies and worms in the same way as a method known to extend longevity of animals including monkeys -- sharply restricting how much they eat.. The finding opens the possibility that people could take a pill to achieve the same benefits as strict dieting to live longer, healthier lives, said David Sinclair of Harvard Medical School in Boston, who led the study. "We found this chemical that can extend longevity of every organism we give it to."

Older adults with a bright outlook on the future may live longer than those who take a dimmer view. 
Researchers in the Netherlands found that older men and women judged to have optimistic personalities were less likely to die over the nine-year study period than those with pessimistic dispositions. Much of this reduced risk was due to lower rates of death from cardiovascular disease among the most optimistic men and women in the study. They were 77 percent less likely to die of a heart attack, stroke or other cardiovascular cause than the most pessimistic group-regardless of factors such as age, weight, smoking and whether they had cardiovascular or other chronic diseases at the study's start.

Use of carnosine as a natural anti-senescence drug for human beings.
Biochemistry 2000.
Carnosine is an endogenous free-radical scavenger. The latest research indicates that apart from the function of protecting cells from oxidation-induced stress damage, carnosine appears to be able to extend the lifespan of cultured cells, rejuvenate senescent cells, inhibit the toxic effects of amyloid peptide (A beta), malondialdehyde, and hypochlorite to cells, inhibit glycosylation of proteins and protein-DNA and protein-protein cross-linking, and maintain cellular homeostasis. Also, carnosine seems to delay the impairment of eyesight with aging, effectively preventing and treating senile cataract and other age-related diseases. Therefore, carnosine may be applied to human being as a drug against aging.

Mitochondria and acetyl-l-carnitine
Mitochondrial decay has been postulated to be a significant underlying part of the aging process. Decline in mitochondrial function may lead to cellular energy deficits, especially in times of greater energy demand, and compromise vital ATP-dependent cellular operations, including detoxification, repair systems, DNA replication, and osmotic balance. Mitochondrial decay may also lead to enhanced oxidant production and thus render the cell more prone to oxidative insult. In particular, the heart may be especially susceptible to mitochondrial dysfunction due to myocardial dependency on beta-oxidation of fatty acids for energy and the postmitotic nature of cardiac myocytes, which would allow for greater accumulation of mitochondrial mutations and deletions. Thus, maintenance of mitochondrial function may be important to maintain overall myocardial function. Herein, we review the major age-related changes that occur to mitochondria in the aging heart and the evidence that two such supplements, acetyl-l-carnitine (ALCAR) and (R)-alpha-lipoic acid, may improve myocardial bioenergetics and lower the increased oxidative stress associated with aging. We and others have shown that feeding old rats ALCAR reverses the age-related decline in carnitine levels and improves mitochondrial beta-oxidation in a number of tissues studied. However, ALCAR supplementation does not appear to reverse the age-related decline in cardiac antioxidant status and thus may not substantially alter indices of oxidative stress. Lipoic acid, a potent thiol antioxidant and mitochondrial metabolite, appears to increase low molecular weight antioxidant status and thereby decreases age-associated oxidative insult. Thus, ALCAR along with alpha lipoic acid may be effective supplemental regimens to maintain myocardial function.

Additional potential longevity enhancers:
Being financially stable
Having a satisfying career
Healing old and new emotional wounds
Having a personal religious or philosophical belief system that gives meaning to this world.
Driving safely, wearing seat belts, minimizing the use of cell phones while driving.

The compound that makes red wine a healthful drink may also hold one of the secrets to longevity. Researchers found that resveratrol acted on fruit flies and worms in the same way as a method known to extend longevity of animals including monkeys -- sharply restricting how much they eat.. The finding opens the possibility that people could take a pill to achieve the same benefits as strict dieting to live longer, healthier lives, said David Sinclair of Harvard Medical School in Boston, who led the study. "We found this chemical that can extend longevity of every organism we give it to."

What is the role of IGF1 in anti-aging?
   There is information about IGF1 hormone.

Heimo korth, The last Alaskans: Of all the most horrible places to not ever if I can help is die in a hospital of all the horrible places in this world to die I'd rather die out here in the Alaskan wilderness, this has been home in the last 40 years.