Monolaurin supplement benefit and side effect
Feb 20 2014 by Ray Sahelian, M.D.

Monolaurin is a form of the fatty acid called lauric acid. It is found in human and coconut milk. In lab experiments, monolaurin has caused damage to a range of microbes but human research is lacking as to the effectiveness of a monolaurin supplement in terms of fighting germs.

Monolaurin can be made through the direct esterification of lauric acid and glycerol. It appears that monolaurin, applied topically, can inhibit the growth of certain microbes.

Monolaurin supplement is available for sale. I have to see human research with monolaurin supplements before giving an opinion.

Monolaurin study
Minimum inhibitory concentrations of herbal essential oils and monolaurin for gram-positive and gram-negative bacteria.
Mol Cell Biochem. 2005. Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC
New, safe antimicrobial agents are needed to prevent and overcome severe bacterial, viral, and fungal infections. Based on our previous experience and that of others, we postulated that herbal essential oils, such as those of origanum, and monolaurin offer such possibilities. We examined in vitro the cidal and/or static effects of oil of origanum, several other essential oils, and monolaurin on Staphylococcus aureus, Bacillus anthracis Sterne, Escherichia coli, Klebsiella pneumoniae, Helicobacter pylori, and Mycobacterium terrae. Origanum proved cidal to all tested organisms with the exception of B. anthracis Sterne in which it was static. Monolaurin was cidal to S. aureus and M. terrae but not to E. coli and K. pneumoniae. Unlike the other two gram-negative organisms, H. pylori were extremely sensitive to monolaurin. Because of their longstanding safety record, origanum and/or monolaurin, alone or combined with antibiotics, might prove useful in the prevention and treatment of severe bacterial infections, especially those that are difficult to treat and/or are antibiotic resistant.

J Med Food. 2013. In vitro and in vivo effects of two coconut oils in comparison to monolaurin on Staphylococcus aureus: rodent studies. Since monolaurin, a monoglyceride formed in the human body in small quantities, has proven effective both in vitro and in vivo against certain strains of Staphylococcus aureus, an important question arises whether consuming a substance high in lauric acid content, such as coconut oil could increase intrinsic monolaurin production to levels that would be successful in overcoming staphylococcal and other microbial invaders. Both a cup plate method and a microdilution broth culture system were employed to test bacteriostatic and bactericidal effects of the test agents in vitro. To test effectiveness in vivo, female C3H/he mice (10-12 per group) were orally administered sterile saline (regular control), vancomycin (positive control), aqueous monolaurin, or two varieties of coconut oil (refined, bleached, deodorized coconut oil and virgin coconut oil) for 1 week before bacterial challenge and 30 days after. A final group received both monolaurin and vancomycin. In contrast to monolaurin, the coconut oils did not show bactericidal activity in vitro. In vivo, the groups receiving vancomycin, monolaurin, or the combination showed some protection--50-70% survival, whereas the protection from the coconut oils were virtually the same as control--0-16% survival. Although we did not find that the two coconut oils are helpful to overcome S. aureus infections, we corroborated earlier studies showing the ability of monolaurin to do such.

Emails
You will be interested in lauricidin dot com. I would appreciate your comments on our research, Prof. Dr. Jon J. Kabara.
   According to the website, Lauricidin  (monolaurin) is the trade name owned by Med-Chem Labs, Inc. for the original, pure monolaurin, a natural lipid (fat) is found in mother's milk, saw palmetto and as a minor lipid component in some coconut oil. In the laboratory, the pure form of this natural lipid has shown antibacterial, antifungal/yeast and antiviral properties. I have to see human research with monolaurin supplements before giving an opinion.

I have been taking monolaurin pellets for over a year for immune support. I often notice the pellets in my bowel movement, so I don't know if its digesting. I am of average weight, healthy, never had any digestive problems, only this time with these have I ever noticed the passing through. Anyway, I emailed the company and they said it sounds like I'm having trouble digesting fats, so my question is, will a digestive enzyme work to correct this problem? I don't know if it is of any benefit, and if it's not, I'd rather not keep spending the money on it. ( I haven't gotten sick since I've been on it, other that my allergy sniffles!)
    I have not seen any long term studies in humans that have evaluated the safety and benefit of such supplements and no studies that have evaluated the combination of this fatty acid taken along with a digestive enzyme.

I am representing a combination of monolaurin and Olive Leaf, and have attached some information on why Monolaurin is protection against the H1N1 virus. I hope that someone there, or the doctor will read this 3 page information on the cytokine storm that is caused by the particularly inpenetrable envelope of this virus, and the ability of Monolaurin to penetrate this envelope, thereby preventing the cytokine storm.
    Until human trials are done giving such a supplement in terms of determining its effect on prevention or treatment of the H1N1 virus, one cannot rely on laboratory or cell tissue studies alone.