Morinda Citrifolia supplement pill - Noni Is it a cure all or just a healthy drink?
Feb 19 2014
by Ray Sahelian, M.D. 

Over the last decade, a growing number of people have become interested in the medicinal uses of noni juice, made from the fruit of the Indian mulberry ( Morinda citrifolia ) of the South Pacific Islands of Tahiti, and more recently from Hawaii. Morinda citrifolia has been used in folk remedies by Polynesians for over 2000 years, and is reported to have a broad range of therapeutic effects, including antibacterial, antiviral, antifungal, antitumor, antihelmin, analgesic, hypotensive, anti-inflammatory, and immune enhancing effects. But does modern scientific research support these claims?

buy Morinda Citrifolia 500 mg

Noni grows extensively throughout the South Pacific, and was at one time the most widely used medicinal plant in the region. This evergreen shrub grows especially well in the rich volcanic ash of Hawaii. Some of the beneficial constituents include various terpene compounds, caproic and caprylic acids, vitamin C and alkaloids. However, Noni is most famous for the presence of an alkoloid proxeronine, which is believed to be a precursor to xeronine.

Supplement Facts
Noni 300 mg
   (Morinda citrifolia) (fruit)
   Freeze Dried Hawaiian

Suggested Use: As an herbal dietary supplement, take one morinda capsule 1 or 2 times daily.

buy Morinda Citrifolia supplement
 

Chemistry
Morinda citrifolia
has been documented to contain a mixture of anthraquinones, organic acids, xeronine, several vitamins (such as beta-carotene, niacin, riboflavin, thiamine), some minerals, iron and calcium. The potassium content is similar to that in tomato juice and orange juice.

Morinda Citrifolia supplement uses - benefit of juice or extract
Claims have been made that
juice or extract improves the immune system, ultimately healing dozens of conditions ranging from addictions to varicose veins and yeast rash. What does the scientific research say about the benefit of Morinda citrifolia juice and extract supplement?

Cancer protection
Antitumour potential of a polysaccharide-rich substance from the fruit juice of Morinda citrifolia on sarcoma 180 ascites tumour in mice.
Phytother Res. 2003.
An immunomodulatory polysaccharide-rich substance (Noni-ppt) from the fruit juice of Morinda citrifolia has been found to possess both prophylactic and therapeutic potentials against the immunomodulator sensitive Sarcoma 180 tumour system. The antitumour activity of
Morinda citrifolia  produced a cure rate of 25%-45% in allogeneic mice and its activity was completely abolished by the concomitant administration of specific inhibitors of macrophages (2-chloroadenosine), T cells (cyclosporine) or natural killer (NK) cells (anti-asialo GM1 antibody). Morinda citrifolia showed synergistic or additive beneficial effects when combined with a broad spectrum of chemotherapeutic drugs, including cisplatin, adriamycin, mitomycin-C, bleomycin, etoposide, 5- fl uorouracil, vincristine or camptothecin. It was not beneficial when combined with paclitaxel, cytosine arabinoside, or immunosuppressive anticancer drugs such as cyclophosphamide, methotrexate or 6-thioguanine. Morinda citrifolia also demonstrated beneficial effects when combined with the Th1 cytokine, interferon gamma, but its activity was abolished when combined with Th2 cytokines, interleukin-4 or interleukin-10, thereby suggesting that Morinda citrifolia induces a Th1 dominant immune status in vivo. The combination of Morinda citrifolia with imexon, a synthetic immunomodulator, also demonstrated beneficial effects, but not when combined with the MVE-2 copolymer, a high molecular weight immunomodulator. Morinda citrifolia was also not effective when combined with interleukin-2 or interleukin-12.

Asian Pac J Cancer Prev. 2013. Morinda citrifolia (Noni) alters oxidative stress marker and antioxidant activity in cervical cancer cell lines. :A decrease in level of lipid peroxidation and an increase in catalase activity were observed with Noni by itself and the effect ameliorated changes observed with cisplatin when given in combination.

Morinda Citrifolia and cholesterol
Reductions in total cholesterol and triglycerides have been seen in smokers who drank a product containing juice from the fruit of the
Morinda citrifolia tree every day for a month. The study was funded by the manufacturer of the product, sold as Tahitian Noni Juice. Researcher Mian-Ying Wang, MD, says she first became interested in studying Morinda citrifolia juice in 1999 after becoming convinced that it helped reduce her pain from a wrist fracture.

Morinda Citrifolia and diabetes
In Java,
Morinda citrifolia has been part of the treatment for diabetes. Most of the folk uses for diabetes involve chewing the leaves or a combination of the plant and leaves. Chewing mulberry leaves releases and activates large amounts of mucilage or insoluble dietary fiber. The fiber may slow the absorption of simple sugars from the gut. The effect in most patients would be a slight reduction in the peak glucose level following a meal.

Infections prevention and treatment
Infections are the most common applications of Morinda species. The extract from the leaves of Morinda citrifolia (not the fruit that renders noni juice) displayed a moderate suppression of Ascaris lumbricoides (intestinal nematodes) growth in the test tube. However,
Morinda citrifolia juice has not been shown to improve infections once symptoms have manifested, although there are anecdotal reports of patients feeling better from mild infections after using noni. Decoctions of the leaves or roots of related mulberry species may have some suppressive effect on parasitic infections.

J Agric Food Chem. 2014 Feb 14. The Anti-adhesion and Anti-inflammation of Morinda citrifolia Fruit extracts on AGS cells During Helicobacter pylori Infection. Helicobacter pylori (H. pylori) is a human gastric pathogen, which adheres to host cell and injects cytotoxin-associated gene A (CagA) to induce interleukin-8 (IL-8), inducible nitric oxide (iNOS) and cyclooxygenase 2 (COX-2). Noni (Morinda citrifolia) is found to possess anti-bacteria, anti-inflammation and anti-oxidation, but its effect on H. pylori infection is still unknown. Ethanol and ethyl acetate extracts of noni fruit were used in this study. The inhibitory effect on CagA and H. pylori-induced IL-8, iNOS and COX-2 were determined. The co-culture medium was collected for measuring neutrophil chemotaxis. Both extracts of noni fruit showed weak inhibition on H. pylori. Both ethanol and ethyl acetate extracts provided anti-adhesion of H. pylori to AGS cells and down-regulation on the CagA, IL-8, COX-2 and iNOS expression. Results also indicated both extracts relieved neutrophil chemotaxis. Noni fruit extracts down-regulated inflammatory responses during H.pylori infection, and the phenolic compounds play key role on anti-adhesion.

Pain
Pain, painful inflammation and swellings are the second most common usage of Morinda species. Studies in mice have demonstrated that extracts from the root of Morinda citrifolia (again, not rendered from the fruit) have some pain relieving and sedative activity.

Side effects of
morinda citrifolia
In some regions of the world Morinda citrifolia and other mulberry species are used as a laxative. Predictably, some patients using higher concentrations of
Morinda citrifolia juice may experience some diarrhea. Although the risk of long-term adverse reactions is not currently known, it should be very low, because of the long history of mulberry species as a food in wide geographic regions. Patients with diabetes would be wise to find out the amount of sugars used to sweeten the particular product they wish to use.
   There have been two reported cases in the medical literature regarding liver damage due to excessive morinda citrifolia juice consumption. As with any herb, it is best to use low amounts. I prefer using small amounts of different herbs as opposed to a large amount of a single herb.

Morinda Citrifolia dosage
Suggested
dose is three capsules per day, taken with a few ounces of water, half an hour before a meal. All three capsules may be taken at once or in divided doses. Three capsules are equivalent to about two tablespoons of liquid Morinda citrifolia juice. A concentrated form of the juice is also available. Morinda citrifolia is often mixed with other fruit juices because of its unpleasant taste.

Conclusion
At this point, there is no firm scientific data to support the use of
Morinda citrifolia juice as a substitute for any standard medical treatment. Patients who are looking for additional help in treating mild infections, cancer or chronic pain could try Morinda citrifolia, realizing that the benefits are not predictable. Perhaps future research will give us additional clues to the potential therapeutic benefits of using Morinda citrifolia juice or extracts. In the meantime, due to its content of various nutrients, Morinda citrifolia juice is a healthy drink to consume as part of an overall balanced diet, as long as you drink no more than one ounce every other day.

Morinda Citrifolia Research
Inhibition of angiogenic initiation and disruption of newly established human vascular networks by juice from Morinda citrifolia.
Angiogenesis. 2003.
The juice of the fruit from the Morinda citrifolia plant has been used for centuries as a medicinal agent. We tested the effects of Morinda citrifolia juice in a three-dimensional fibrin clot matrix model using human placental vein and human breast tumor explants as sources for angiogenic vessel development. Morinda citrifolia in concentrations of 5% (vol/vol) or greater was highly effective in inhibiting the initiation of new vessel sprouts from placental vein explants, compared with initiation in control explants in media supplemented with an equivalent amount of saline. These concentrations of Morinda citrifolia were also effective in reducing the growth rate and proliferation of newly developing capillary sprouts. When used at a concentration of 10% in growth media, Morinda citrifolia was able to induce vessel degeneration and apoptosis in wells with established capillary networks within a few days of its application. We also found that 10% Morinda citrifolia juice in media was an effective inhibitor of capillary initiation in explants from human breast tumors. In tumor explants which did show capillary sprouting, the vessels rapidly degenerated (2-3 days) in those exposed to media supplemented with 10% Morinda citrifolia.

Cancer preventive effect of Morinda citrifolia.
Department of Pathology, UIC College of Medicine, Rockford, Illinois, USA.
Morinda citrifolia Noni has been extensively used in folk medicine by Polynesians for over 2,000 years. It has been reported to have broad therapeutic effects, including anticancer activity, in both clinical practice and laboratory animal models. The hypothesis that it possesses a cancer preventive effect at the initiation stage of carcinogenesis was studied. Our preliminary data indicated that 10% Tahitian Noni Liquid Dietary Supplement or Tahitian Noni Juice, made from Morinda citrifolia fruit by Morinda Inc, in drinking water for one week was able to prevent DMBA-DNA adduct formation. The antioxidant activity of Morinda citrifolia was compared to the effects of vitamin C, grape seed powder, and pycnogenol at the daily dose per serving level recommended by U.S. RDAs or manufacturers. The results suggest that prevention of carcinogen-DNA adduct formation and the antioxidant activity of Morinda citrifolia may contribute to the cancer preventive effect of Morinda citrifolia.

Questions
Q. Can a morinda citrifolia supplement be used the same day as curcumin herb or saw palmetto?
   A. I don't see why not.

Q. Do you know if Proxene ES by Biomolecular is everything it say's it is? Proxene ES is a supplement that is supposed to make you feel young again.
   A. Proxene ES apparently has 1,000mg Morinda Citrifolia. Morinda Citrifolia has some health benefits, but so do many other plants.

Q. I have been reading about Morinda Citrifolia on your web site and would like to know if it is unsafe to use on a daily basis at 1000 mg as with Bio-Molecular Solutions product.
   A. We are not familiar with Bio-Molecular Solutions product.