Green Lipped Mussel pills and their use for arthritis conditions
Feb 19 2014 by
Ray Sahelian, M.D.

Nutritional supplements which contain freeze-dried tissue from the New Zealand green-lipped mussel Perna canaliculus are sold in many countries to relieve arthritic symptoms and to aid in the regeneration of arthritic and injured joints and for the treatment of rheumatoid arthritis and osteoarthritis. One brand name is Lyprinol.

Green-lipped mussel inhibits inflammation in the body. Although inflammation is normal under certain conditions, consistent or excessive inflammation can result in pain and damage to the body, including the joints. The human body makes several chemical mediators of inflammation. Levels of these chemicals in the body may be higher in people with rheumatoid arthritis who are experiencing symptoms than in symptom-free people with arthritis. Evidence indicates that controlling the production of inflammatory mediators in the body may help improve conditions such as arthritis, asthma, psoriasis, and inflammatory bowel disease (including ulcerative colitis and Crohn’s disease), all of which involve elements of inflammation.

There is little consistent and compelling evidence, to date, in the therapeutic use of freeze-dried green-lipped mussel powder products for rheumatoid or osteoarthritis treatment, particularly in comparison to other cheaper alternative nutriceutical supplements of proven efficacy.

Open Access J Sports Med. 2013. Marine oil dietary supplementation reduces delayed onset muscle soreness after a 30 km run. Runners are prone to delayed onset muscle soreness (DOMS) during long distance training. This especially holds for unaccustomed training volumes at moderate to high intensities. We investigated the effects of a marine oil complex, PCSO-524®, derived from the New Zealand green-lipped mussel (formulated as Lyprinol® and Omega XL®) on DOMS after a 30 km training run.

New Zealand green-lipped mussel fatty acid composition
The major fatty acids of New Zealand green-lipped mussel are docosahexaenoic acid (DHA: 22:6 n-3) (19%), eicosapentaenoic acid (EPA; 20:5 n-3) and palmitic acid (16:0), both 15%. Cholesterol is the most prominent sterol (31% of total sterols). Other major sterols include desmosterol / brassicasterol, 24-methylenecholesterol, trans-22-dehydrocholesterol, 24-nordehydrocholesterol and occelasterol.

Molluscs and Bivalves
Bivalves are two shelled aquatic molluscs, bilaterally symmetrical and laterally compressed. Bivalves include mussels, scallops, cockles, oysters, clams and the unusual shipworms.

Green Lipped Mussel Research
Systematic review of a marine nutraceutical supplement in clinical trials for arthritis: the effectiveness of the New Zealand green-lipped mussel Perna canaliculus.
Clinical Rheumatology. 2005
Complementary Medicine, Institute of Health and Social Care Research, Peninsula Medical School, Universities of Exeter and Plymouth, 25 Victoria Park Road, Exeter, EX2 4NT, UK
Nutritional supplements, such as Seatone, which contain freeze-dried tissue from the New Zealand green-lipped mussel Perna canaliculus, are sold in many countries to relieve arthritic symptoms and to aid in the regeneration of arthritic and injured joints. Searches for all published controlled trials on the clinical effectiveness of green-lipped mussel, as a nutritional supplement with potential health benefits for arthritis, were carried out from four independent databases. No language restrictions were imposed. Reports of clinical studies, using freeze-dried mussel powder, show mixed outcome measures and are not conclusive, with only two of five randomized controlled trials attesting benefits for rheumatoid and osteoarthritis patients. Similarly, animal studies have likewise yielded mixed findings. In both these cases possibly due to the lack of stabilization of the omega-3 polyunsaturated fatty acids, now known to be the basis of anti-inflammatory activity. There is little consistent and compelling evidence, to date, in the therapeutic use of freeze-dried green-lipped mussel powder products for rheumatoid or osteoarthritis treatment, particularly in comparison to other cheaper alternative nutriceutical supplements of proven efficacy. However, further investigations are necessary to determine whether green-lipped mussel supplements, such as Seatone, are therapeutic options in the management of arthritis.

Gas chromatography-chemical ionization-mass spectrometric fatty acid analysis of a commercial supercritical carbon dioxide lipid extract from New Zealand green-lipped mussel (Perna canaliculus).
Lipids. 2005. Division of Nutritional Sciences, Savage Hall, Cornell University, Ithaca, New York, USA.
Supercritical fluid extracts of New Zealand green-lipped mussels have been suggested to have therapeutic properties related to their oil components. The large number of minor fatty acids in New Zealand green-lipped mussels extract was characterized. The extract contained five major lipid classes: sterol esters, TAG, FFA, sterols, and polar lipids. The total fatty acid content of the lipid extract was 0.66 g/mL. Fifty-three unsaturated fatty acids (UFA) were fully identified, of which 37 were PUFA, and a further 21 UFA were detected for which concentrations were too low for assignment of double-bond positions. There were 17 saturated fatty acids, with 14:0, 16:0, and 18:0 present in the greatest concentration. The 10 n-3 PUFA detected included 20:5n-3 and 22:6n-3, the two main n-3 FA; n-3 PUFA at low concentrations were 18:3, 18:4, 20:3, 20:4, 21:5, 22:5, 24:6, and 28:8. There were 43 UFA from the n-4, n-5, n-6, n-7, n-8, n-9, n-10, n-1 families, with 16:2n-4, 16:1n-5, 18:1n-5, 18:2n-6, 20:4n-6, 16:1n-7, 20:1n-7, 16:1n-9, 18:1 n-9, and 20:1 n-9 being the most abundant. These data demonstrate a remarkable diversity of New Zealand green-lipped mussels fatty acids.

Lyprinol ( stabilised lipid extract of New Zealand green-lipped mussel ): a potential preventative treatment modality for inflammatory bowel disease.
J Gastroenterol. 2005.. Child Health Research Institute, Women's and Children's Hospital, North Adelaide, South Australia, Australia.
Lyprinol (Pharmalink International), the stabilised lipid extract of the New Zealand green-lipped mussel, is currently used to relieve symptoms of arthritis. We investigated the effect of pretreatment with lipid extract of the New Zealand green-lipped mussel on experimentally induced inflammatory bowel disease (IBD) in mice. Male C57BL/6 mice (aged 6 weeks) were gavaged daily for 13 days with (150 microl) olive oil (OO; n = 7), fish oil (FO; n = 8), or LYP (n = 8). Mice consumed 2% dextran sulfate sodium (DSS) for 6 days, starting on day 7. Body weight and disease activity index (DAI) scores were recorded daily. Colonic damage was determined by histopathology. Colonic inflammation was quantified by myeloperoxidase (MPO) activity. Lipid extract of the New Zealand green-lipped mussel treatment significantly reduced body weight loss, DAI scores, crypt area losses, and cecum and colon weights, compared with FO treatment. MPO activity was not significantly affected by any treatment. These findings provide preliminary evidence that lipid extract of the New Zealand green-lipped mussel may be potentially useful in ameliorating symptoms of IBD. The benefit, however, is unlikely to be due to the omega-3 fatty acid content. Dose-response evaluation of lipid extract of the New Zealand green-lipped mussel in experimental IBD is warranted.

The major fatty acids of New Zealand green-lipped mussel are docosahexaenoic acid (DHA: 22:6 n-3) (19%), eicosapentaenoic acid (EPA; 20:5 n-3) and palmitic acid (16:0), both 15%. Cholesterol is the most prominent sterol (31% of total sterols). Other major sterols include desmosterol / brassicasterol, 24-methylenecholesterol, trans-22-dehydrocholesterol, 24-nordehydrocholesterol and occelasterol.

questions
Q. Can a green lipped mussel supplement and serrapeptase be taken the same day? What about AHCC?
     A. I would prefer not mixing too many of these supplements together since little research is available regarding their individual use, let alone the combinations.