N-Acetylneuraminic acid (Neu5Ac or NANA) is the primary sialic acid found in
mammalian cells. It is found in complex glycans on mucins and glycoproteins
found at the cell membrane. Neu5Ac residues are also found in glycolipids, such
as gangliosides, a crucial component of neuronal membranes found in the brain.
Feb 14 2016
We are not aware of specific human research.
Biochemistry. 2013 Nov 26. Structural basis for substrate specificity and mechanism of N-acetyl-D-neuraminic acid lyase from Pasteurella multocida. N-Acetylneuraminate lyases (NALs) or sialic acid aldolases catalyze the reversible aldol cleavage of N-acetylneuraminic acid (Neu5Ac, the most common form of sialic acid) to form pyruvate and N-acetyl-d-mannosamine.
J Exp Med. 2013.O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia. The development of resistance to chemotherapy is a major cause of relapse in acute lymphoblastic leukemia (ALL). Though several mechanisms associated with drug resistance have been studied in detail, the role of carbohydrate modification remains unexplored. Here, we investigated the contribution of 9-O-acetylated N-acetylneuraminic acid (Neu5Ac) to survival and drug resistance development in ALL cells. A strong induction of 9-O-acetylated Neu5Ac including 9-O-acetyl GD3 was detected in ALL cells that developed resistance against vincristine or nilotinib, drugs with distinct cytotoxic mechanisms. Removal of 9-O-acetyl residues from Neu5Ac on the cell surface by an O-acetylesterase made ALL cells more vulnerable to such drugs. Moreover, removal of intracellular and cell surface-resident 9-O-acetyl Neu5Ac by lentiviral transduction of the esterase was lethal to ALL cells in vitro even in the presence of stromal protection. Interestingly, expression of the esterase in normal fibroblasts or endothelial cells had no effect on their survival. Transplanted mice induced for expression of the O-acetylesterase in the ALL cells exhibited a reduction of leukemia to minimal cell numbers and significantly increased survival. This demonstrates that Neu5Ac 9-O-acetylation is essential for survival of these cells and suggests that Neu5Ac de-O-acetylation could be used as therapy to eradicate drug-resistant ALL cells.
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Presently the following studies have been carried out with sialic acid.
1. Anti-virus function
2. Anti-cancer function
3. Anti-inflammation function
4. Defensive function against bacteriological infection
5. Controlling ability of immune system
6. Restraining ability against pigmentation
7. Signal transformation in nerve cells
8. Play a key role in brain development and learning
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Shanghai Accobio Inc. is a professional nutritional ingredients supplier located in China , we are specializing in R&D, production and marketing of food additives, pharmaceutical intermediates, and fine chemicals. We have our own science and technology team working on the research and manufacture of the nutraceutical products, as well as the stable and reliable supplying channel of the Nutraceutical raw materials and natural extracts. Our products are mainly exported to USA and the European countries, etc, and enjoy a high reputation from our customers. Our partner: Shanghai Asian Development Prosperous Import And Export Co.,Ltd