Naringin health benefit, reduces damage from radiation exposure by Ray Sahelian, M.D.
July 14 2014

Naringin is one of the citrus bioflavonoids.

The common citrus bioflavonoids include:
Apigenin -- found in high amounts in parsley, Thyme, and peppermint and many other herbs including lemon balm.
Hesperidin -- found in citrus peel and pulp -- commercial orange juice provides 444 mg/l hesperidin
Hesperitin --
Naringenin is the aglycone of Naringin.
Narirutin -- commercial orange juice provides 96 mg narirutin per liter 
Nobiletin -- a citrus bioflavonoid isolated from tangerines
Quercetin is found in high amounts in onions, kale, hot peppers, and rutabagos.
Rutin
Tangeretin
Tangeritin

NADH for mind

Autoimmune arthritis
Cell Immunol. Feb 2014. Amelioration of autoimmune arthritis by naringin through modulation of T regulatory cells and Th1/Th2 cytokines.

Metabolic syndrome prevention or treatment
Flavonoids are important natural compounds with diverse biologic activities. Citrus flavonoids constitute an important series of flavonoids. Naringin and its aglycone naringenin belong to this series of flavonoids and were found to display strong anti-inflammatory and antioxidant activities. Several lines of investigation suggest that naringin supplementation is beneficial for the treatment of obesity, diabetes, hypertension, and metabolic syndrome. A number of molecular mechanisms underlying its beneficial activities have been elucidated. However, their effect on obesity and metabolic disorder remains to be fully established. Moreover, the therapeutic uses of these flavonoids are significantly limited by the lack of adequate clinical evidence. This review aims to explore the biologic activities of these compounds, particularly on lipid metabolism in obesity, oxidative stress, and inflammation in context of metabolic syndrome. Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms of Action, Advances in Nutrition, July 2014.

Research
The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice.
J Nutr. 2004.
Dietary antioxidant compounds such as bioflavonoids may offer some protection against the early stage of diabetes mellitus and the development of complications. We investigated the effect of citrus bioflavonoids on blood glucose level, hepatic glucose-regulating enzymes activities, hepatic glycogen concentration, and plasma insulin levels, and assessed the relations between plasma leptin and body weight, blood glucose, and plasma insulin. The current results suggest that hesperidin and naringin both play important roles in preventing the progression of hyperglycemia, partly by increasing hepatic glycolysis and glycogen concentration and/or by lowering hepatic gluconeogenesis.

Naringin, a citrus flavonone, protects against radiation-induced chromosome damage in mouse bone marrow.
Mutagenesis. 2003.
Antioxidants are known to scavenge free radicals, thereby decreasing the degree of chromosome aberrations. Radiation is a well-known inducer of free radicals and compounds that can scavenge free radicals may reduce radiation-induced DNA damage. Naringin, a bioflavonoid predominant in grapefruit and other citrus fruits, has been found to scavenge free radicals, therefore it may also reduce radiation-induced damage. The aim of the present study was to evaluate the radioprotective action of 2 mg/kg naringin in the bone marrow of mice exposed to different doses of (60)Co gamma-radiation by scoring the frequency of asymmetrical chromosomal aberrations. The irradiation of mice resulted in a dose-dependent elevation in the frequency of aberrant cells, acentric fragments, chromatid and chromosome breaks, dicentrics and exchanges. All these aberrations were elevated with scoring time up to 24 h post-irradiation and declined thereafter, except chromatid breaks, which were maximum at 12 h post-irradiation. Treatment of mice with 2 mg/kg body wt naringin before exposure to various doses of gamma-radiation resulted in a significant reduction in the frequencies of aberrant cells and chromosomal aberrations like acentric fragments, chromatid and chromosome breaks, centric rings, dicentrics and exchanges. The evaluation of free radical scavenging activity of naringin revealed a dose-dependent scavenging of hydroxyl, superoxide and 2,2 equal to or precedes -diphenyl-1-picryl hydrazyl radical. Naringin at 5 microM scavenged the 2,2-azino-bis-3-ethyl benzothiazoline-6-sulphonic acid cation radical very efficiently, where a 90% scavenging was observed. Our study demonstrates that naringin can protect mouse bone marrow cells against radiation-induced chromosomal damage.

Questions
Q. Hi Doctor, do you know of a brand of naringin or naringenin. Iíve been searching and canít find anything. The amounts in some vitamin C / bioflavinoid complexes is too little. Also, is it found in Bergamot?
   A. If you search google, you will find products that only contain naringin. We can't a product that only has it by itself. Yes.