Natriuretic peptide and relation to heart tissue
Feb 16 2016 by
Ray Sahelian, M.D.

Heart ventricles produce B-type natriuretic peptide (BNP or Beta natriuretic peptide) in response to increased mechanical load and wall stretch. B type natriuretic peptide is a hormone which protects the heart from adverse consequences of overload by increasing natriuresis and diuresis, relaxing vascular smooth muscle, inhibiting the renin-angiotensin-aldosterone system, and by counteracting cardiac hypertrophy and fibrosis. Patients with elevated levels of natriuretic terminal pro-B type natriuretic peptide (NT-proBNP) and interleukin-6 (IL-6) have an increased risk of short- and long-term mortality.

Heart tissue and BNP
Alcohol use, physical activity, diet, and cigarette smoking are modifiable cardiovascular risk factors that have a substantial impact on the risk of myocardial infarction, stroke, and cardiovascular death.

B-type natriuretic peptide is synthesized by human cardiac myocytes as a prohormone (proBNP), which is cleaved to the 32-residue BNP and the 76-residue N-terminal fragment of proBNP. Both can be used as sensitive biomarkers of cardiac dysfunction and well-characterized commercial assays have recently become available. In acute coronary syndromes increased concentrations are strong predictors of recurring heart attack, heart failure, and death.

Stroke. 2014. Usefulness of N-Terminal Pro-B-Type Natriuretic Peptide Levels for Stroke Risk Prediction in Anticoagulated Patients With Atrial Fibrillation. In real-world cohort of anticoagulated patients with AF, NT-proBNP provided complementary prognostic information to an established clinical risk score (CHA2DS2-VASc) for the prediction of stroke/systemic embolism. NT-proBNP was also predictive of all-cause mortality, suggesting that this biomarker may potentially be used to refine clinical risk stratification in anticoagulated patients with AF.

Brain natriuretic peptide
A brain natriuretic peptide (BNP) test measures the amount of the BNP hormone in your blood. BNP is made by your heart and tells how well your heart is working. Normally, only a low amount of beta natriuretic peptide is found in your blood. However, if your heart has to work harder over a long period of time, such as from heart failure, the heart releases more BNP and the blood level of BNP will get higher.

Atrial natriuretic peptide information
This is released by myocytes in response to atrial stretch. There are a variety of forms; the originals isolated from the brain were smaller than the forms subsequently isolated from human heart.
   Treatment with intravenous atrial natriuretic peptide (ANP) before and after primary coronary angioplasty for a first acute anterior MI protects the heart against reperfusion injury and prevents left ventricular remodeling.

B-type natriuretic peptide and Congestive Heart failure
B-type natriuretic peptide and N-terminal pro-BNP (NT-proBNP) levels can indicate a variety of heart problems, as well as general critical illness. B-type natriuretic peptide and NT-proBNP assays are useful for evaluating patients with acute dyspnea, as a low level of natriuretic peptide can help rule out congestive heart failure (CHF) and reduce reliance on echocardiography. Conversely, these assays can be particularly useful in recognizing CHF in a patient with acute dyspnea and a history of chronic obstructive pulmonary disease. However, clinical judgment must always be part of the evaluation of B-type natriuretic peptide or NT-proBNP assay results.

Questions
Q. Does CoQ10 influence natriuretic peptide levels? What about LJ100?
     A. I'm not sure. I haven't seen much research regarding the influence of CoQ10 on natriuretic peptide or tongkat ali.